{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T09:07:02Z","timestamp":1789204022737,"version":"build-2803163510"},"reference-count":29,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cell Transplant"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:p>Donor-specific antibodies (DSA) are preformed recipient antibodies directed against donor HLA antigens, most frequently observed in haploidentical or mismatched allogeneic hematopoietic cell transplantation (HCT). DSA assessed by multiplexed bead-based immunoassays at mean fluorescence intensity (MFI) values &gt;1 000 are associated with increased risk of graft failure, graft-versus-host disease (GvHD), and mortality, supporting combined pharmacological and plasma-based depletion in absence of matching donors. We retrospectively analyzed all adult HCTs performed between 2009 and 2025 at the University Hospital T\u00fcbingen, Germany, with clinically relevant DSA (MFI &gt;1 000). Assessments included depletion strategies, engraftment, GvHD, overall survival, and immune reconstitution. A 2:1 matched control cohort without DSA was selected based on disease, age, sex, and donor features. Fourteen cases were identified (1.2% of all transplants; 9.1% of haploidentical procedures). Depletion regimens included rituximab (n=12), bortezomib (n=10), daratumumab (n=2), intravenous immunoglobulins (n=6), plasma exchange (n=8), and immunoadsorption (n=9). MFI reduction &lt;1 000 before HCT was achieved in 5 of 11 evaluable patients. All but two recipients engrafted timely; both graft failures occurred after single-modality depletion. Clinical outcomes did not differ significantly between DSA patients and controls. These real-world data underscore the importance of systematic DSA screening and multimodal depletion to optimize transplantation outcomes.<\/jats:p>","DOI":"10.1177\/09636897261486247","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T06:31:01Z","timestamp":1789021861000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Management of donor-specific antibodies in allogeneic hematopoietic cell transplantation: A retrospective single-center case-control study"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6430-051X","authenticated-orcid":false,"given":"Lennart","family":"Harland","sequence":"first","affiliation":[{"name":"University Hospital T\u00fcbingen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9381-1381","authenticated-orcid":false,"given":"Semian L.","family":"Sch\u00fcch","sequence":"additional","affiliation":[{"name":"University Hospital T\u00fcbingen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Katzenstein","sequence":"additional","affiliation":[{"name":"University Hospital T\u00fcbingen,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Hammer","sequence":"additional","affiliation":[{"name":"University Hospital T\u00fcbingen"},{"name":"University Hospital T\u00fcbingen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Faul","sequence":"additional","affiliation":[{"name":"University Hospital T\u00fcbingen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina","family":"Althaus","sequence":"additional","affiliation":[{"name":"University Hospital T\u00fcbingen"},{"name":"University Hospital T\u00fcbingen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard N.","family":"Bohnert","sequence":"additional","affiliation":[{"name":"University Hospital T\u00fcbingen,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2513-1317","authenticated-orcid":false,"given":"Markus W.","family":"L\u00f6ffler","sequence":"additional","affiliation":[{"name":"University Hospital T\u00fcbingen"},{"name":"University Hospital T\u00fcbingen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamam","family":"Bakchoul","sequence":"additional","affiliation":[{"name":"University Hospital T\u00fcbingen"},{"name":"University Hospital T\u00fcbingen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Lengerke","sequence":"additional","affiliation":[{"name":"University Hospital T\u00fcbingen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang A.","family":"Bethge","sequence":"additional","affiliation":[{"name":"University Hospital T\u00fcbingen"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,9]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-017-0062-8"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2021.04.030"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-023-01932-6"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40487-024-00283-6"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-015-0182-9"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2024.09.005"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023011893"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021004862"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-022-04844-5"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110299"},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-024-02251-0"},{"key":"e_1_3_7_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1701119"},{"key":"e_1_3_7_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31822872dd"},{"issue":"2","key":"e_1_3_7_15_2","first-page":"224","article-title":"Prediction of blood volume in normal human adults","volume":"51","author":"Nadler SB","year":"1962","unstructured":"Nadler SB, Hidalgo JH, Bloch T. 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