{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:56:34Z","timestamp":1792083394042,"version":"4.4.0"},"reference-count":57,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"(1) The Shanghai \u201cRising Stars of Medical Talents\u201d Youth Development Program","award":["SHWSRS(2025)_071"],"award-info":[{"award-number":["SHWSRS(2025)_071"]}]},{"name":"(2) Shanghai Angecon Biotechnology Co., Ltd."}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cell Transplant"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To evaluate the safety and efficacy of intranasal transplantation of ANGE-S003 human neural stem cells (hNSCs) in early-onset Parkinson\u2019s disease (EOPD) patients with motor complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this randomized, double-blind, placebo-controlled trial, 24 EOPD patients were randomized (2:1) to receive weekly intranasal administrations of 1.5 \u00d7 10\n                      <jats:sup>7<\/jats:sup>\n                      hNSCs or placebo for 4 weeks, followed by 12 months of follow-up. The primary endpoint was change in MDS-UPDRS Part IV score at month 6.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>No significant difference was observed in the primary endpoint (least-squares mean difference, 0.42; 95% CI, \u22124.29 to 5.13; P = 0.853). Controls showed greater worsening of off-state MDS-UPDRS Part III motor scores in non-onset limbs at 12 months (P = 0.029). Exploratory 11C-CFT PET analyses demonstrated greater reductions in dopaminergic activity in the non-onset caudate (P = 0.022) and anterior putamen (P = 0.045) in controls versus the treatment group. A total of 137 adverse events and 6 serious adverse events were reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Although the primary endpoint was not met, motor and neuroimaging findings provide preliminary signals of a potential treatment effect. Larger studies are needed to confirm efficacy and safety.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09636897261494929","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:00:31Z","timestamp":1791914431000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Intranasal human neural stem cell therapy in early-onset Parkinson\u2019s disease with motor complications: A randomized, double-blind, placebo-controlled trial"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3182-1285","authenticated-orcid":false,"given":"Kangwen","family":"Peng","sequence":"first","affiliation":[{"name":"Tongji University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Guan","sequence":"additional","affiliation":[{"name":"Tongji 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