{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:58:52Z","timestamp":1787504332527,"version":"build-2736575974"},"reference-count":52,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[1994,11,1]],"date-time":"1994-11-01T00:00:00Z","timestamp":783648000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Transplant"],"published-print":{"date-parts":[[1994,11]]},"abstract":"<jats:p>Platelet-derived growth factor (PDGF) has trophic effect on dopaminergic neurons in vitro. We have previously shown dynamic changes in the expression of PDGF in embryonic mesencephalic grafts and surrounding host striatal tissue following intracerebral transplantation in a rat model of Parkinson's disease. In this study the expression of the PDGF receptors was examined in the same model using immunohistochemistry. Most ventral mesencephalic (VM) cells from E13\u2013E15 rat embryos possessed both PDGF \u03b1-and \u03b2-receptors before implantation. Double immunofluorescence staining revealed that about 10% of the cells also expressed tyrosine hydroxylase (TH). The PDGF \u03b1-receptor was detectable in the graft up to 1 wk after transplantation but had disappeared at 3 wk. In the host tissue, scattered glial cells were positive for the \u03b1-receptor but the expression was unchanged following transplantation. The \u03b2-receptor expression almost completely disappeared from the grafted tissue by 4 h following transplantation, and only a few cells of the host striatum showed immunoreactivity. However, after 3 wk \u03b2-receptor positive cells were again detectable in the graft. These cells appeared to be endothelial cells as identified by an antibody against von Willebrand's factor. Our data suggest that PDGF might act locally on embryonic dopaminergic cells in an autocrine or juxtacrine manner before and shortly after transplantation, and on surrounding glial cells in a paracrine manner after transplantation. Furthermore, PDGF-BB might influence neovascularization in the graft.<\/jats:p>","DOI":"10.1177\/096368979400300602","type":"journal-article","created":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T15:23:34Z","timestamp":1498145014000},"page":"453-460","source":"Crossref","is-referenced-by-count":9,"title":["Platelet-Derived Growth Factor Receptor Expression after Neural Grafting in a Rat Model of Parkinson's Disease"],"prefix":"10.1177","volume":"3","author":[{"given":"Andrea E.","family":"Ballagi","sequence":"first","affiliation":[{"name":"Ludwig Institute for Cancer Research, Biomedical Center, S-751 24 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Odin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Restorative Neurology Unit, University Hospital, S-221 85 Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agneta","family":"Othberg-Cederstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Neurology, Restorative Neurology Unit, University Hospital, S-221 85 Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Smits","sequence":"additional","affiliation":[{"name":"Ludwig Institute for Cancer Research, Biomedical Center, S-751 24 Uppsala, Sweden"},{"name":"Department of Neurology, University Hospital, S-751 85 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Ming","family":"Duandr","sequence":"additional","affiliation":[{"name":"Department of Neurology, Restorative Neurology Unit, University Hospital, S-221 85 Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olle","family":"Lindvall","sequence":"additional","affiliation":[{"name":"Department of Neurology, Restorative Neurology Unit, University Hospital, S-221 85 Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Funa","sequence":"additional","affiliation":[{"name":"Ludwig Institute for Cancer Research, Biomedical Center, S-751 24 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1994,11]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"545.4","article-title":"TGF-\u03b1 selectively increases dopaminergic cell survival in ventral mesencephalic cultures.","volume":"18","author":"Alexi T.","year":"1992","unstructured":"AlexiT.; HelftiF. 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Cancer Res. 50: 748753; 1990.","journal-title":"Cancer Res."},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(93)90038-H"},{"key":"e_1_2_1_18_2","first-page":"453","volume-title":"Growth factors. B. Med. Bull.","author":"Heldin C.-H.","year":"1989","unstructured":"HeldinC.-H.; WestermarkB. Platelet-derived growth factors: A family of isoforms that bind to two distinct receptors. In: Waterfield, eds. Growth factors. B. Med. Bull. vol. 45. Churchill Livingstone; 1989: 453464."},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.1.8.555"},{"key":"e_1_2_1_20_2","first-page":"3213","article-title":"Platelet-derived growth factor and its receptors in human glioma tissue: Expression of messenger RNA and protein suggests the presence of autocrine and paracrine loops.","volume":"52","author":"Hermanson M.","year":"1992","unstructured":"HermansonM.; FunaK.; HartmanM.; Claesson-WelshL.; HeldinC.-H.; WestermarkB.; Nist\u00e9rM. 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