{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:49:21Z","timestamp":1777510161546,"version":"3.51.4"},"reference-count":44,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1995,3,1]],"date-time":"1995-03-01T00:00:00Z","timestamp":794016000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Transplant"],"published-print":{"date-parts":[[1995,3]]},"abstract":"<jats:p>Four cynomolgus monkeys were trained on a hand reaching task and then rendered hemiparkinsonian with an intracarotid injection of n-methyl 4 phenyl 1,2,3,6, tetrahydropyridine (MPTP). Performance on this task with the limb contralateral to the MPTP injection was significantly impaired following the lesion. Three monkeys received implants of polymer-encapsulated containing PC12 cells into the caudate nucleus and putamen. One monkey received identical implants of empty capsules and served as a control. After a transient improvement, limb use in the control monkey dissipated and returned to post-MPTP disability. Two of the three PC12 cell grafted monkeys recovered performance on the hand reach task to near normal levels for up to 6.5 mo posttransplantation. Capsules retrieved from the monkeys who recovered limb function postimplantation contained numerous viable PC12 cells that continued to release levodopa, basal dopamine, and potassium evoked dopamine. In contrast, capsules retrieved from the PC12 cell-grafted monkey which did not recover limb use on the hand reach task contained few cells which secreted negligible or undetectable levels of levodopa and dopamine. Interestingly, functional disability was not reinstated following removal of the capsules. Neuroanatomical and neurochemical evaluation of the grafted striatum did not reveal a host-derived sprouting response of catecholaminergic or indolaminergic fibers. These data indicate that xenografts of PC12 cells can survive for up to 6.5 mo in nonimmunosuppressed monkeys when immunoisolated via polymer encapsulation. Moreover, these cells continue to secrete high levels of levodopa and dopamine and induce recovery of motor function in parkinsonian nonhuman primates.<\/jats:p>","DOI":"10.1177\/096368979500400203","type":"journal-article","created":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T15:21:55Z","timestamp":1498144915000},"page":"155-171","source":"Crossref","is-referenced-by-count":7,"title":["Encapsulated PC 12 Cell Transplants into Hemiparkinsonian Monkeys: A Behavioral, Neuroanatomical, and Neurochemical Analysis"],"prefix":"10.1177","volume":"4","author":[{"given":"Jeffrey H.","family":"Kordower","sequence":"first","affiliation":[{"name":"Department of Neurological Sciences and Rush Alzheimer's Disease Center, Rush Presbyterian Medical Center, 2242 West Harrison Street, Chicago IL 60612"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue-Ting","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences and Rush Alzheimer's Disease Center, Rush Presbyterian Medical Center, 2242 West Harrison Street, Chicago IL 60612"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shelley","family":"Winn","sequence":"additional","affiliation":[{"name":"Cyto Therapeutics Inc., Providence RI 02902"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dwaine F.","family":"Emerich","sequence":"additional","affiliation":[{"name":"Cyto Therapeutics Inc., Providence RI 02902"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,6,22]]},"reference":[{"key":"bibr1-096368979500400203","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(91)90093-R"},{"key":"bibr2-096368979500400203","doi-asserted-by":"publisher","DOI":"10.1016\/0142-9612(91)90132-T"},{"key":"bibr3-096368979500400203","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1994.1053"},{"key":"bibr4-096368979500400203","doi-asserted-by":"publisher","DOI":"10.1007\/BF00979534"},{"key":"bibr5-096368979500400203","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1987.tb23705.x"},{"key":"bibr6-096368979500400203","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(86)90431-5"},{"key":"bibr7-096368979500400203","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(08)60329-5"},{"key":"bibr8-096368979500400203","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1990.72.2.0231"},{"key":"bibr9-096368979500400203","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(88)90069-X"},{"key":"bibr10-096368979500400203","doi-asserted-by":"publisher","DOI":"10.1007\/BF00248542"},{"key":"bibr11-096368979500400203","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(05)80185-X"},{"key":"bibr12-096368979500400203","doi-asserted-by":"publisher","DOI":"10.1177\/096368979300200308"},{"key":"bibr13-096368979500400203","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1993.1105"},{"key":"bibr14-096368979500400203","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903490110"},{"key":"bibr15-096368979500400203","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(88)90080-5"},{"key":"bibr16-096368979500400203","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-185291-7.50021-7"},{"key":"bibr17-096368979500400203","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199211263272202"},{"key":"bibr18-096368979500400203","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198902093200601"},{"key":"bibr19-096368979500400203","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.40.2.273"},{"key":"bibr20-096368979500400203","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.41.11.1719"},{"key":"bibr21-096368979500400203","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.73.7.2424"},{"key":"bibr22-096368979500400203","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(85)90446-9"},{"key":"bibr23-096368979500400203","doi-asserted-by":"publisher","DOI":"10.1177\/29.4.6166661"},{"key":"bibr24-096368979500400203","doi-asserted-by":"publisher","DOI":"10.1038\/350230a0"},{"key":"bibr25-096368979500400203","doi-asserted-by":"publisher","DOI":"10.1007\/BF00261353"},{"key":"bibr26-096368979500400203","first-page":"443","volume-title":"Therapeutic approaches to Parkinson's disease.","author":"Kordower J.H.","year":"1990"},{"key":"bibr27-096368979500400203","first-page":"175","volume-title":"Scientific basis for therapy in Parkinson's disease.","author":"Kordower J.H.","year":"1992"},{"key":"bibr28-096368979500400203","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1990.73.3.0418"},{"key":"bibr29-096368979500400203","first-page":"565","volume":"29","author":"Kordower J.H.","journal-title":"Ann. 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