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To this end, the major strategies to implant cells and tissues are through: (i) the pretreatment of the graft to reduce tissue immunogenicity; (ii) the application of immunoisolation technologies to prevent host sensitization to implanted cells; and (iii) the induction of immunological tolerance to the donor tissues. Further, a major dilemma facing clinical tissue grafting is the shortage of donor tissue for transplantation. This problem requires the consideration of tissues from other species (xenografts) as a potential source of donor material. In light of these issues, the focus of this discussion is on the T cell-dependent response to allogeneic and xenogeneic transplants and the implications of this reactivity on the field of cellular replacement therapy.<\/jats:p>","DOI":"10.1177\/096368979500400407","type":"journal-article","created":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T15:22:36Z","timestamp":1498144956000},"page":"361-370","source":"Crossref","is-referenced-by-count":13,"title":["Immunobiology of Cellular Transplantation"],"prefix":"10.1177","volume":"4","author":[{"given":"Ronald G.","family":"Gill","sequence":"first","affiliation":[{"name":"Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Box B140, Denver, CO 80262"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leslie","family":"Wolf","sequence":"additional","affiliation":[{"name":"Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Box B140, Denver, CO 80262"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,6,22]]},"reference":[{"key":"bibr1-096368979500400407","first-page":"1","volume":"126","author":"Aebischer P.","year":"1991","journal-title":"Exp. 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