{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:55:02Z","timestamp":1777510502151,"version":"3.51.4"},"reference-count":13,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[1996,11,1]],"date-time":"1996-11-01T00:00:00Z","timestamp":846806400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Transplant"],"published-print":{"date-parts":[[1996,11]]},"abstract":"<jats:p>We have recently documented that oral Linomide (quinoline-3-carboxamide) prevents autoimmune insulitis, islet destruction, and diabetes in NOD mice treated at an early stage (5 wk of age) of the disease. In this report, we show that treatment of female NOD mice with advanced disease (age 23-24 wk) by syngeneic islet transplantation and oral Linomide administration results in prevention of graft insulitis and diabetes in the Linomide group up to 40 wk (diabetes at 40 wk: isograft recipients with Linomide n = 0 of 6; isograft recipients alone n = 5 of 6; p &lt; 0.0001). The extent of protection from glucose intolerance by the combination of transplantation with Linomide was superior to that of Linomide alone [blood glucose (mean \u00b1 SD) 60 min post-i.p. injection of 1 g\/kg body weight glucose: Linomide plus isograft 6.7 \u00b1 1 mmol\/L; Linomide alone 18.7 \u00b1 6.3 mmol\/L; p &lt; 0.0001]. Thus, Linomide should be considered a potential immunoregulatory modality in patients undergoing pancreatic islet or whole organ transplantation.<\/jats:p>","DOI":"10.1177\/096368979600500605","type":"journal-article","created":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T15:19:42Z","timestamp":1498144782000},"page":"627-630","source":"Crossref","is-referenced-by-count":4,"title":["Successful Treatment of Diabetes in Nod Mice with Advanced Disease by Islet Isografts following Immunoregulation with Linomide (Quinoline-3-Carboxamide)"],"prefix":"10.1177","volume":"5","author":[{"given":"Shimon","family":"Slavin","sequence":"first","affiliation":[{"name":"Departments of Bone Marrow Transplantation & Cancer Immunobiology Research Laboratory and Endocrinology & Metabolism, Hadassah University Hospital and the Hebrew University-Hadassah Medical School, P.O. Box 12000, Jerusalem, Israel 91120"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lola","family":"Weiss","sequence":"additional","affiliation":[{"name":"Departments of Bone Marrow Transplantation & Cancer Immunobiology Research Laboratory and Endocrinology & Metabolism, Hadassah University Hospital and the Hebrew University-Hadassah Medical School, P.O. Box 12000, Jerusalem, Israel 91120"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Wenlang","sequence":"additional","affiliation":[{"name":"Departments of Bone Marrow Transplantation & Cancer Immunobiology Research Laboratory and Endocrinology & Metabolism, Hadassah University Hospital and the Hebrew University-Hadassah Medical School, P.O. Box 12000, Jerusalem, Israel 91120"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Gross","sequence":"additional","affiliation":[{"name":"Departments of Bone Marrow Transplantation & Cancer Immunobiology Research Laboratory and Endocrinology & Metabolism, Hadassah University Hospital and the Hebrew University-Hadassah Medical School, P.O. Box 12000, Jerusalem, Israel 91120"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,6,22]]},"reference":[{"key":"bibr1-096368979600500605","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199005000-00001"},{"key":"bibr2-096368979600500605","doi-asserted-by":"publisher","DOI":"10.1007\/BF00399792"},{"key":"bibr3-096368979600500605","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199304000-00045"},{"key":"bibr4-096368979600500605","doi-asserted-by":"publisher","DOI":"10.2337\/diab.16.1.35"},{"key":"bibr5-096368979600500605","volume":"24","author":"Lakey J.R.","year":"1992","journal-title":"Transplant. 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Invest."},{"key":"bibr12-096368979600500605","doi-asserted-by":"publisher","DOI":"10.1002\/dmr.5610090411"},{"key":"bibr13-096368979600500605","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-198803000-00024"}],"container-title":["Cell Transplantation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/096368979600500605","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/096368979600500605","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:37:11Z","timestamp":1777390631000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1177\/096368979600500605"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,11]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1996,11]]}},"alternative-id":["10.1177\/096368979600500605"],"URL":"https:\/\/doi.org\/10.1177\/096368979600500605","relation":{},"ISSN":["0963-6897","1555-3892"],"issn-type":[{"value":"0963-6897","type":"print"},{"value":"1555-3892","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,11]]}}}