{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:55:21Z","timestamp":1777510521257,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1997,3,1]],"date-time":"1997-03-01T00:00:00Z","timestamp":857174400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Transplant"],"published-print":{"date-parts":[[1997,3]]},"abstract":"<jats:p>Histochemistry for visualization of the mitochondrial enzyme cytochrome oxidase has been used to detect cellular and regional differences in brain energy metabolism. We have examined the pattern of cytochrome oxidase (CO) staining in grafts of embryonic ventral mesencephalic tissue, and in the implanted striatum, of MPTP-treated monkeys as one index of the functional activity of grafted tissue and its influence on the host brain. Four monkeys were selected for study based on interesting variations in dopamine (DA) neuron content of their bilateral grafts as demonstrated with tyrosine-hydroxylase (TH) immunocytochemistry. The results suggest that grafts rich in DA neurons increase the metabolic activity of the implanted striatum of DA-depleted monkeys, and that this improvement of local energy metabolism is greater in the vicinity of grafts containing greater numbers of DA neurons. In addition, the pattern of CO staining within tissue transplants indicates that DA neurons exhibit the highest rate of metabolic activity among all cell types contained in the ventral mesencephalic grafts, and that the transplants receive metabolically active innervation from outside or within the grafted tissue.<\/jats:p>","DOI":"10.1177\/096368979700600207","type":"journal-article","created":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T15:18:33Z","timestamp":1498144713000},"page":"135-140","source":"Crossref","is-referenced-by-count":5,"title":["Metabolic Energy Capacity of Dopaminergic Grafts and the Implanted Striatum in Parkinsonian Nonhuman Primates as Visualized with Cytochrome Oxidase Histochemistry"],"prefix":"10.1177","volume":"6","author":[{"given":"Timothy J.","family":"Collier","sequence":"first","affiliation":[{"name":"Department of Neurological Sciences, Research Center for Brain Repair, Rush Presbyterian Medical Center, Tech 2000, Chicago, IL 60612, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"D. Eugene","family":"Redmond","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Pharmacology, Yale University School of Medicine, New Haven, CT 06510"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert H.","family":"Roth","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Pharmacology, Yale University School of Medicine, New Haven, CT 06510"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John D.","family":"Elsworth","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Pharmacology, Yale University School of Medicine, New Haven, CT 06510"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane R.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Pharmacology, Yale University School of Medicine, New Haven, CT 06510"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"John R.","family":"Sladek","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Finch University of Health Sciences\/The Chicago Medical School, North Chicago, IL 60064, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1997,3]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902220102"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(91)90105-L"},{"key":"e_1_2_1_4_2","first-page":"199","article-title":"Cytochrome oxidase patches: A new cytoar- chitectonic feature of monkey visual cortex.","volume":"304","author":"Horton J.C.","year":"1984","unstructured":"Horton J.C. Cytochrome oxidase patches: A new cytoar- chitectonic feature of monkey visual cortex. Philos. Trans. R. Soc. Lond. (Biol.) 304: 199\u2013253; 1984.","journal-title":"Philos. Trans. R. Soc. Lond. 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