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As we move toward considering relationships as a public health issue, understanding mechanistic pathways in relationships\u2013health links is crucial for designing efficient and effective interventions. In this review, we outline criteria for establishing a construct as a relationships\u2013health mechanism. We then discuss how best to test potential mechanisms of relationships\u2013health links and identify some promising mechanism candidates on the basis of initial evidence (emotion, attachment, sleep, and substance abuse). 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