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Acute responses to daily stressors can differ widely among individuals experiencing the same stressor, and these physiological responses may not align with stress appraisals. This review highlights individual and dyadic factors that may heighten and prolong stress reactivity, along with their implications for health. We discuss depression, rumination, early life adversity, and social evaluation as individual-level factors and interpersonal stress processes and relationship quality as dyadic-level factors that may influence physiological stress responses. Heightened and prolonged stress reactivity can provide a gateway to the physiological dysregulation that underlies depression and chronic disease, which themselves alter stress reactivity\u2014a vicious cycle. Interventions that may dampen physiological stress reactivity include yoga, meditation, health behaviors (diet, exercise, and sleep), and cognitive behavior therapy.<\/jats:p>","DOI":"10.1177\/0963721420949521","type":"journal-article","created":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T19:23:15Z","timestamp":1599679395000},"page":"492-498","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":88,"title":["Stress Reactivity: What Pushes Us Higher, Faster, and Longer\u2014and Why It Matters"],"prefix":"10.1177","volume":"29","author":[{"given":"Janice K.","family":"Kiecolt-Glaser","sequence":"first","affiliation":[{"name":"The Institute for Behavioral Medicine Research, The Ohio State University College of Medicine"},{"name":"Department of Psychiatry and Behavioral Health, The Ohio State University College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan E.","family":"Renna","sequence":"additional","affiliation":[{"name":"The Institute for Behavioral Medicine Research, The Ohio State University College of Medicine"},{"name":"The Comprehensive Cancer Center, The Ohio State University College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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