{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:51:26Z","timestamp":1777380686171,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T00:00:00Z","timestamp":1591660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acupunct Med"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To investigate whether the mechanism underlying the anti-inflammatory effects of electroacupuncture (EA) at ST36 involves dopamine (DA) and its receptor and whether it is mediated by the vagus nerve in a rat model of intestinal ischaemia-reperfusion (I\/R) injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Rats were subjected to gut ischaemia for 30 min and then received EA for 30 min with or without abdominal vagotomy or intraperitoneal administration of butaclamol (D1 receptor antagonist) or spiperone (D2 receptor antagonist). Plasma levels of DA and tumour necrosis factor (TNF)-\u03b1 were assessed 1 or 4 h after reperfusion. Myeloperoxidase (MPO) activity and malondialdehyde (MDA) content in intestinal tissues were assessed using enzyme-linked immunosorbent assay (ELISA) kits. Intestinal tissue injury was assessed by observation of the pathological lesions and permeability to 4 kDa fluorescein isothiocyanate (FITC)-dextran.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>EA significantly increased levels of DA and lowered levels of TNF-\u03b1. EA also inhibited intestinal levels of MPO and MDA and intestinal tissue injury and decreased intestinal permeability to FITC-dextran. Abdominal vagotomy and intraperitoneal administration of butaclamol (but not spiperone) inhibited the effects of EA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings suggest that EA at ST36 could attenuate intestinal I\/R-induced inflammatory injury and that the underlying mechanism may involve EA-induced increases in levels of DA, mediated by the vagus nerve and D1 receptors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0964528420922232","type":"journal-article","created":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T00:10:25Z","timestamp":1591747825000},"page":"208-216","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Electroacupuncture alleviates intestinal inflammation and barrier dysfunction by activating dopamine in a rat model of intestinal ischaemia"],"prefix":"10.1177","volume":"39","author":[{"given":"Yumeng","family":"Li","sequence":"first","affiliation":[{"name":"Department of Encephalopathy, Anyang Hospital of Traditional Chinese Medicine, Anyang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guochen","family":"Xu","sequence":"additional","affiliation":[{"name":"Out-Patient Department, Fourth Medical Center of the Chinese PLA General Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sen","family":"Hu","sequence":"additional","affiliation":[{"name":"Laboratory of Shock and Multiple Organ Dysfunction, Trauma Research Center, Fourth Medical Center of the Chinese PLA General Hospital, Beijing, China"},{"name":"Research Center of Trauma Repair and Tissue Regeneration, Medical Innovation Research Department, Chinese PLA General Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Encephalopathy, Anyang Hospital of Traditional Chinese Medicine, Anyang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuelong","family":"Dai","sequence":"additional","affiliation":[{"name":"Chinese People\u2019s Armed Police Force Academy, Langfang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenhua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Laboratory of Shock and Multiple Organ Dysfunction, Trauma Research Center, Fourth Medical Center of the Chinese PLA General Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fubo","family":"Tang","sequence":"additional","affiliation":[{"name":"Chengdu Hospital of Sichuan Provincial Corps, Chinese People\u2019s Armed Police Force, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongmin","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Burns and Wound Repair Surgery, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xian","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Acupuncture and Moxibustion, Chinese PLA General Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,6,9]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(99)00231-7"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00024382-200115010-00001"},{"issue":"2","key":"e_1_3_7_4_2","first-page":"92","article-title":"Effect of acuptreatment on plasma interleukin 6 and tumor necrosis factor \u03b1 levels in type II diabetic patients complicated with acute cerebral infarction","volume":"8","author":"Chen J","year":"2001","unstructured":"Chen J, Liang H, Ma Y. 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