{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T18:33:59Z","timestamp":1793126039440,"version":"4.5.0"},"reference-count":32,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2021,7,24]],"date-time":"2021-07-24T00:00:00Z","timestamp":1627084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acupunct Med"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Hyperalgesic priming (HP) is a model of the transition from acute to chronic pain. Electroacupuncture (EA) could inhibit pain development through the peripheral dorsal root ganglia; however, it is unclear whether it can mitigate the transition from acute to chronic pain by attenuating protein expression in the p38 MAPK (mitogen-activated protein kinase)\/tumour necrosis factor alpha (TNF-\u03b1) pathway in the spinal dorsal horn.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>We aimed to determine whether EA could prevent the transition from acute to chronic pain by affecting the p38 MAPK\/TNF-\u03b1 pathway in the spinal dorsal horn in a rat model established using HP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We first randomly subdivided 30 male Sprague-Dawley (SD) rats into 5 groups ( n = 6 per group): control (N), sham HP (Sham-HP), HP, HP + SB203580p38 MAPK (HP+SB203580), and HP + Lenalidomide (CC-5013) (HP+Lenalidomide). We then randomly subdivided a further 30 male SD rats into 5 groups ( n = 6 per group): Sham-HP, HP, sham EA (Sham EA), EA (EA), and EA + U-46619 p38 MAPK agonist (EA+U-46619). We assessed the effects of EA on the mechanical paw withdrawal threshold and p38 MAPK\/TNF-\u03b1 expression in the spinal dorsal horn of rats subjected to chronic inflammatory pain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Rats in the EA group had reduced p38 MAPK and TNF-\u03b1 expression and had significantly reduced mechanical hyperalgesia compared with rats in the other groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our findings indicate that EA could increase the mechanical pain threshold in rats and inhibit the transition from acute pain to chronic pain. This mechanism could involve reduced p38 MAPK\/TNF-\u03b1 expression in the spinal dorsal horn.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09645284211020766","type":"journal-article","created":{"date-parts":[[2021,7,24]],"date-time":"2021-07-24T05:33:45Z","timestamp":1627104825000},"page":"708-715","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Electroacupuncture alleviates the transition from acute to chronic pain through the p38 MAPK\/TNF-\u03b1 signalling pathway in the spinal dorsal horn"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9731-2307","authenticated-orcid":false,"given":"Ying","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Acupuncture and Rehabilitation, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing City, China"},{"name":"The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou City, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhou","sequence":"additional","affiliation":[{"name":"The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou City, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangfang","family":"Xu","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou City, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeqin","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation in Traditional Chinese Medicine, The First Affiliated Hospital, Dali University, Dali City, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Acupuncture and Rehabilitation, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing City, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Acupuncture and Rehabilitation, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing City, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiwen","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Acupuncture and Rehabilitation, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing City, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanying","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Acupuncture and Rehabilitation, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing City, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,7,24]]},"reference":[{"key":"bibr1-09645284211020766","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000004673"},{"key":"bibr2-09645284211020766","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2231"},{"key":"bibr3-09645284211020766","doi-asserted-by":"publisher","DOI":"10.1177\/0022034516653604"},{"key":"bibr4-09645284211020766","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109299"},{"key":"bibr5-09645284211020766","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2017.11.007"},{"key":"bibr6-09645284211020766","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2015.05.046"},{"key":"bibr7-09645284211020766","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/8403064"},{"key":"bibr8-09645284211020766","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-020-4064-2"},{"key":"bibr9-09645284211020766","doi-asserted-by":"publisher","DOI":"10.1007\/s11302-018-9617-4"},{"key":"bibr10-09645284211020766","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2004.10.021"},{"key":"bibr11-09645284211020766","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(94)90144-9"},{"key":"bibr12-09645284211020766","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-012-9881-8"},{"key":"bibr13-09645284211020766","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2110-17.2017"},{"key":"bibr14-09645284211020766","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000513"},{"key":"bibr15-09645284211020766","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3481-14.2015"},{"key":"bibr16-09645284211020766","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-3-33"},{"key":"bibr17-09645284211020766","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2017.02.005"},{"key":"bibr18-09645284211020766","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2015.10.006"},{"key":"bibr19-09645284211020766","doi-asserted-by":"publisher","DOI":"10.1002\/glia.10308"},{"key":"bibr20-09645284211020766","doi-asserted-by":"publisher","DOI":"10.1007\/s00776-011-0052-4"},{"key":"bibr21-09645284211020766","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/9383184"},{"key":"bibr22-09645284211020766","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4170-07.2008"},{"key":"bibr23-09645284211020766","doi-asserted-by":"publisher","DOI":"10.1136\/acupmed-2017-011559"},{"key":"bibr24-09645284211020766","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-018-1358-3"},{"key":"bibr25-09645284211020766","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharep.2019.07.001"},{"key":"bibr26-09645284211020766","doi-asserted-by":"publisher","DOI":"10.1172\/JCI72230"},{"key":"bibr27-09645284211020766","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5147-13.2015"},{"key":"bibr28-09645284211020766","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23451"},{"key":"bibr29-09645284211020766","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2012.01.006"},{"key":"bibr30-09645284211020766","first-page":"848603","volume":"2015","author":"Liu 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