{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T12:08:00Z","timestamp":1783080480309,"version":"3.54.6"},"reference-count":37,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T00:00:00Z","timestamp":1632355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acupunct Med"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>To determine the effects of post-treatment electroacupuncture (EA) on the electrophysiological properties of ventricular muscle in rats with ischemia\/reperfusion (IR) injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Male Sprague\u2013Dawley (SD) rats were randomly assigned into sham-operated (SH), IR and IR\u2009+\u2009EA groups ( n\u2009=\u20098 each). The IR model was generated by ligation of the left anterior descending (LAD) coronary artery for 30\u2009min. After establishing the IR model, EA was administered at PC6 for 30\u2009min while opening the coronary artery and allowing reperfusion for 30\u2009min. Heart rate (HR), mean arterial pressure and monophasic action potential (MAP) of cardiac muscle in the outer membrane of the antetheca of the left ventricle before coronary artery ligation ( T\n                      <jats:sub>0<\/jats:sub>\n                      ), after coronary artery ligation for 30\u2009min ( T\n                      <jats:sub>1<\/jats:sub>\n                      ) and after reperfusion for 30\u2009min ( T\n                      <jats:sub>2<\/jats:sub>\n                      ) were recorded. At the same time, ventricular electrophysiological parameters including ventricular effective refractory period (ERP), conduction velocity (CV) and ventricular fibrillation threshold (VFT) were measured. Then, the cardiac function and the levels of creatine kinase-muscle\/brain (CK-MB) and cardiac troponin I (cTnI) were monitored. Based on these data, monophasic action potential amplitude (MAPA), the maximum depolarization velocity ( V\n                      <jats:sub>max<\/jats:sub>\n                      ) and the MAP durations at 50% and 90% repolarization (MAPD\n                      <jats:sub>50<\/jats:sub>\n                      and MAPD\n                      <jats:sub>90<\/jats:sub>\n                      ) were calculated to determine the incidence of arrhythmia during reperfusion.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Compared with the SH group, the IR group showed an obviously decreased HR as well as reduced mean arterial pressure, V\n                      <jats:sub>max<\/jats:sub>\n                      , CV, ERP and MAPA. All indices of cardiac function except left ventricular end-diastolic pressure (LVEDP) decreased (i.e. ventricular systolic pressure (LVSP), left ventricular ejection fraction (LVEF), fractional shortening (FS) and rate of the ventricular pressure rise\/drop (\u00b1dp\/dt)). Furthermore, the MAPD\n                      <jats:sub>50<\/jats:sub>\n                      and MAPD\n                      <jats:sub>90<\/jats:sub>\n                      were prolonged, and the levels of CK-MB and cTnI increased ( p\u2009&lt;\u20090.05). In comparison to the IR group, HR and the mean arterial pressure were increased. All indices of cardiac function except LVEDP increased (LVSP, LVEF, FS and \u00b1dp\/dt). V\n                      <jats:sub>max<\/jats:sub>\n                      , CV, ERP and MAPA were also increased in the IR\u2009+\u2009EA group. However, MAPD\n                      <jats:sub>50<\/jats:sub>\n                      and MAPD\n                      <jats:sub>90<\/jats:sub>\n                      were distinctly shortened, and the levels of CK-MB and cTnI decreased ( p\u2009&lt;\u20090.05). There were no statistically significant differences in VFT between the three groups ( p\u2009&gt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>EA post-treatment can relieve prolongation of repolarization and slowed depolarization of ventricular muscle during IR, thus decreasing the rate of incidence of reperfusion arrhythmia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09645284211039229","type":"journal-article","created":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T07:19:26Z","timestamp":1632381566000},"page":"89-98","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Effects of post-treatment electroacupuncture on ventricular monophasic action potential and cardiac function in a rat model of ischemia\/reperfusion injury"],"prefix":"10.1177","volume":"40","author":[{"given":"Jian","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxin","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Guizhou Medical University, Guiyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqiu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The Fourth People\u2019s Hospital of Guiyang, Guiyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, No. 3 Affiliated Hospital of Guizhou Medical University, Duyun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanliang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Surgical, Universit\u00e4t Heidelberg, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suisui","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Guizhou Medical University, Guiyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,9,23]]},"reference":[{"key":"bibr1-09645284211039229","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13019-017-0568-6","volume":"12","author":"Ferng AS","year":"2017","journal-title":"Cardiothorac 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