{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:53:15Z","timestamp":1777380795104,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T00:00:00Z","timestamp":1632355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100012553","name":"chang gung memorial hospital","doi-asserted-by":"publisher","award":["CMRPG 3E1041"],"award-info":[{"award-number":["CMRPG 3E1041"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005795","name":"chang gung memorial hospital, linkou","doi-asserted-by":"publisher","award":["CMRPG3D0891"],"award-info":[{"award-number":["CMRPG3D0891"]}],"id":[{"id":"10.13039\/501100005795","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"ministry of science and technology, taiwan","doi-asserted-by":"publisher","award":["MOST 103-2320-B-182-002-MY3"],"award-info":[{"award-number":["MOST 103-2320-B-182-002-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acupunct Med"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>A hyperdynamic circulation and impaired vascular responsiveness to vasoconstrictors are observed in portal hypertension (PHT) rats. Inflammation is a major contributor to the hyperdynamic circulation state in murine models of PHT. Electroacupuncture (EA) may ameliorate the inflammatory response and limit arterial vasodilatation and portal pressure. This study investigated the possible mechanisms underlying putative hemodynamics effects of EA in normal and PHT rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>PHT was induced by bile duct ligation (BDL) surgery over 4\u2009weeks in rats. Sham-operated and BDL rats were treated with low-frequency EA (2\u2009Hz) at ST36 10\u2009min three times weekly for one or two consecutive weeks (for a total of 3 or 7 treatments, respectively). Serum tumor necrosis factor-\u03b1 (TNF-\u03b1), nitrite\/nitrate (NOx) and 6-keto-prostaglandin F1\u03b1 (6-keto-PGF1\u03b1) were analyzed, and hemodynamic variation and contractile responses to phorbol-12,13-dibutyrate and phenylephrine in aortic and superior mesenteric arterial rings were recorded. Inducible (i) and endothelial (3) nitric oxide synthase (NOS), cyclooxygenase-1 (COX-1), and protein kinase C-\u03b1 (PKC-\u03b1) levels were determined by Western blotting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>EA significantly reduced portal pressure and serum TNF-\u03b1, NOx and 6-keto-PGF1\u03b1 levels compared to the untreated BDL group, enhanced maximum contractile responses in the aorta, up-regulated PKC-\u03b1, and down-regulated iNOS and COX-1 levels. In addition, EA decreased the aortic angiogenesis signaling cascade, reflected by down-regulation of vascular endothelial growth factor (VEGF) abundance and transforming growth factor \u03b2 receptor (TGF\u03b2R)I\/II expression, as assessed by immunostaining.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>EA attenuates TNF-\u03b1, NO and 6-keto-PGF1\u03b1 overproduction, modulates the vascular levels of constitutive NOS and PKC-\u03b1, blunts the development of the angiogenesis cascade, and enhances vascular contractile force in PHT rats.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09645284211039230","type":"journal-article","created":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T07:28:31Z","timestamp":1632382111000},"page":"68-77","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Electroacupuncture attenuates vascular hyporeactivity in a rat model of portal hypertension induced by bile duct ligation"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8902-648X","authenticated-orcid":false,"given":"Yu-Sheng","family":"Chen","sequence":"first","affiliation":[{"name":"Graduate Institute of Clinical Medical Science, College of Medicine, Chang Gung University, Taoyuan, Taiwan"},{"name":"Division of Acupuncture and Moxibustion, Department of Traditional Chinese Medicine, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan"},{"name":"Taiwan Huangdi-Neijing Medical Practice Association (THMPA), Taoyuan, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chorng-Kai","family":"Wen","sequence":"additional","affiliation":[{"name":"School of Post-Baccalaureate Chinese Medicine, Tzu Chi University, Hualien, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geng-Hao","family":"Liu","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Medical Science, College of Medicine, Chang Gung University, Taoyuan, Taiwan"},{"name":"Division of Acupuncture and Moxibustion, Department of Traditional Chinese Medicine, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan"},{"name":"Taiwan Huangdi-Neijing Medical Practice Association (THMPA), Taoyuan, Taiwan"},{"name":"School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tzung-Yan","family":"Lee","sequence":"additional","affiliation":[{"name":"Graduate Institute of Traditional 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