{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T09:15:17Z","timestamp":1781946917995,"version":"3.54.5"},"reference-count":39,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T00:00:00Z","timestamp":1632355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"national natural science foundation of china","doi-asserted-by":"publisher","award":["81904302"],"award-info":[{"award-number":["81904302"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017950","name":"shanghai municipal health commission","doi-asserted-by":"publisher","award":["2017BR047 and 201840174"],"award-info":[{"award-number":["2017BR047 and 201840174"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shanghai Sailing Program","award":["19YE1445000"],"award-info":[{"award-number":["19YE1445000"]}]},{"DOI":"10.13039\/xxx","name":"natural science foundation of shanghai","doi-asserted-by":"publisher","award":["19ZR1451600 and 21ZR1460100"],"award-info":[{"award-number":["19ZR1451600 and 21ZR1460100"]}],"id":[{"id":"10.13039\/xxx","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acupunct Med"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Electroacupuncture (EA) treatment has been found to ameliorate clinical symptoms in patients with dry eye, but its mechanisms are still not entirely clear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To study the regulation of EA on ocular surface function and the corneal reactive oxygen species (ROS)\/thioredoxin-interacting protein (TXNIP)\/Nod-like receptor protein 3 (NLRP3) inflammatory signaling pathway in dry eye syndrome (DES) model rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Male Sprague-Dawley (SD) rats were randomly divided into five groups: Normal, Model, Model + EA, Model + NAC (N-actetylcysteine) and Model + NS (normal saline). The DES model was developed by subcutaneous injection of scopolamine hydrobromide with exposure to an air draft in the latter four groups. After intervention, the Schirmer I test (SIT), tear film break-up time (BUT) and ROS content were measured, the histopathological changes of corneal tissues were observed, and the mRNA and protein expression levels of TXNIP, NLRP3, apoptosis-associated Speck-like protein containing CARD (ASC), caspase-1, interleukin (IL)-1\u03b2 and IL-18 were detected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Compared with the Model group, the SIT and BUT increased significantly in the Model + EA group after intervention (p &lt; 0.05), and the corneal injury was improved. Corneal ROS content declined in both Model + EA and Model + NAC groups (p &lt; 0.05), and mRNA expression of TXNIP, NLRP3, ASC and caspase-1 also decreased (p &lt; 0.01). Corneal protein expression of TXNIP, NLRP3, IL-1\u03b2 and IL-18 decreased significantly in the Model + EA group (p &lt; 0.01).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Inhibiting the ROS\/TXNIP\/NLRP3 signaling pathway may be the mechanism underlying the role of EA in improving corneal injury in DES model rats.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09645284211039235","type":"journal-article","created":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T07:29:34Z","timestamp":1632382174000},"page":"78-88","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Electroacupuncture inhibits the corneal ROS\/TXNIP\/NLRP3 signaling pathway in a rat model of dry eye syndrome"],"prefix":"10.1177","volume":"40","author":[{"given":"Yanting","family":"Yang","sequence":"first","affiliation":[{"name":"Laboratory of Acupuncture-Moxibustion and Immunology, Shanghai Research Institute of Acupuncture and Meridian, Shanghai, China"},{"name":"Yueyang Clinical Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0747-8691","authenticated-orcid":false,"given":"Dan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Laboratory of Acupuncture-Moxibustion and Immunology, Shanghai Research Institute of Acupuncture and Meridian, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijie","family":"Wu","sequence":"additional","affiliation":[{"name":"Acupuncture-Moxibustion Department, The First Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine, Hangzhou, 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