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Acupuncture is known to increase dopamine secretion and is widely used to treat myopia clinically.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The aim of this study was to determine if acupuncture inhibits myopia progression in form deprived Syrian hamsters by inducing rises in dopamine content that in turn suppress inflammasome activation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Acupuncture was applied at LI4 and Taiyang every other day for 21\u2009days. The levels of molecules associated with the dopamine signaling pathway, inflammatory signaling pathway and inflammasome activation were determined. A dopamine agonist (apomorphine) was used to evaluate if activation of the dopaminergic signaling pathway suppresses myopia progression by inhibiting inflammasome activation in primary retinal pigment epithelial (RPE) cells. A dopamine receptor 1 (D1R) inhibitor (SCH39166) was also administered to the hamsters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Acupuncture inhibited myopia development by increasing dopamine levels and activating the D1R signaling pathway. Furthermore, we also demonstrated that nucleotide-binding oligomerization domain (NOD)-, leucine-rich repeat (LRR)- and pyrin domain-containing protein 3 (NLR) family pyrin domain-containing 3 (NLRP3) inflammasome activation was inhibited by activation of the D1R signaling pathway.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our findings suggest that acupuncture inhibits myopia development by suppressing inflammation, which is initiated by activation of the dopamine\u2014D1R signaling pathway.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09645284231170886","type":"journal-article","created":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T00:35:01Z","timestamp":1684715701000},"page":"364-375","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Acupuncture modulates development of myopia by reducing NLRP3 inflammasome activation via the dopamine-D1R signaling pathway"],"prefix":"10.1177","volume":"41","author":[{"given":"Chih-Sheng","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Food Nutrition and Health Biotechnology, Asia University, Taichung"},{"name":"Division of Chinese Medicine, Asia University Hospital, Taichung"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9525-3232","authenticated-orcid":false,"given":"Chi-Fong","family":"Lin","sequence":"additional","affiliation":[{"name":"PhD Program for Health Science and Industry, China Medical University, Taichung"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yung-Lan","family":"Chou","sequence":"additional","affiliation":[{"name":"School of Chinese Medicine, China Medical University, Taichung"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Der-Yen","family":"Lee","sequence":"additional","affiliation":[{"name":"Graduate Institute of Integrated Medicine, China Medical University, Taichung"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng-Tai","family":"Tien","sequence":"additional","affiliation":[{"name":"Eye Center, China Medical University Hospital, Taichung"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao-Chien","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Taichung Tzu Chi Hospital, Taichung"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching-Yao","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Science and Biotechnology, Asia University, Taichung"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"En-Shyh","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Beauty Science, National Taichung University of Science and Technology, Taichung"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamie Jiin","family":"Chen","sequence":"additional","affiliation":[{"name":"Eye Center, China Medical University Hospital, Taichung"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Yen","family":"Wu","sequence":"additional","affiliation":[{"name":"Eye Center, China Medical University Hospital, Taichung"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsiangyu","family":"Ku","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Science, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, People\u2019s Republic of 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Taichung"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Wan","sequence":"additional","affiliation":[{"name":"School of Chinese Medicine, China Medical University, Taichung"},{"name":"Department of Medical Laboratory Science and Biotechnology, Asia University, Taichung"},{"name":"Department of Obstetrics and Gynecology, China Medical University Hospital, Taichung"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,5,21]]},"reference":[{"key":"bibr1-09645284231170886","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60272-4"},{"key":"bibr2-09645284231170886","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.07.041210"},{"key":"bibr3-09645284231170886","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2016.01.006"},{"key":"bibr4-09645284231170886","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2010.09.020"},{"key":"bibr5-09645284231170886","volume-title":"The myopias: basic 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