{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:56:15Z","timestamp":1777380975451,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2024,11,23]],"date-time":"2024-11-23T00:00:00Z","timestamp":1732320000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Support plan of Anhui University of traditional Chinese Medicine","award":["2022rcyb023"],"award-info":[{"award-number":["2022rcyb023"]}]},{"name":"Anhui Natural Science Foundation","award":["1908085MH289"],"award-info":[{"award-number":["1908085MH289"]}]},{"DOI":"10.13039\/501100001809","name":"national natural science foundation of china","doi-asserted-by":"publisher","award":["81273858"],"award-info":[{"award-number":["81273858"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"national natural science foundation of china","doi-asserted-by":"publisher","award":["81674058"],"award-info":[{"award-number":["81674058"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National key Research and Development Plan","award":["2018YFC1704600"],"award-info":[{"award-number":["2018YFC1704600"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acupunct Med"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>\n                      To determine the effect of electroacupuncture (EA) on \u03b2\n                      <jats:sub>1<\/jats:sub>\n                      -adrenergic receptor (\u03b2\n                      <jats:sub>1<\/jats:sub>\n                      -AR) and post-receptor protein kinase A (PKA) signaling pathway after acute myocardial ischemia (MI).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      An MI model was established by ligating the left anterior descending coronary artery of wild-type (WT) C57\/BL and \u03b2\n                      <jats:sub>1<\/jats:sub>\n                      -AR\n                      <jats:sup>+\/\u2013<\/jats:sup>\n                      mice (heterozygous for \u03b2\n                      <jats:sub>1<\/jats:sub>\n                      -AR gene deletion). EA treatment was administered at HT5-HT7 or LU9-LU8. We evaluated cardiac function by measuring ST segment displacement, ischemic area and serum levels of creatine kinase (CK)-MB and lactate dehydrogenase (LDH). Pathological morphology\/apoptosis of myocardial tissue were examined using hematoxylin\u2013eosin and terminal deoxynucleotidyl transferase dUTP nick end labeling staining. Norepinephrine (NE) levels in myocardial tissue were detected by ELISA. Levels of \u03b2\n                      <jats:sub>1<\/jats:sub>\n                      and post-receptor PKA signaling components were evaluated by quantitative reverse transcription polymerase chain reaction (qRT-PCR) and Western blotting.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      EA stimulation at HT7-HT5 could better regulate the level of \u03b2\n                      <jats:sub>1<\/jats:sub>\n                      -AR in myocardial tissue than that at LU9-LU8. Following EA, the ST segment, serum CK-MB\/ LDH and area of myocardial infarction were decreased in WT mice, and the degree of myocardial pathology\/apoptosis and expression of cleaved caspase-3 were decreased. Myocardial levels of Gs protein (Gs), adenylate cyclase (AC), cyclic adenosine monophosphate (cAMP), phosphorylated protein kinase A (p-PKA), L-type voltage-gated calcium channel \u03b11C (Cav1.2), serine phosphate 16-phospholamban (p-PLB\n                      <jats:sup>s16<\/jats:sup>\n                      ) and sarcoplasmic reticulum Ca\n                      <jats:sup>2+<\/jats:sup>\n                      -adenosine triphosphate (ATP)ase 2a (SERCA2a) increased after EA. However, these effects of EA were not replicated in \u03b2\n                      <jats:sub>1<\/jats:sub>\n                      -AR\n                      <jats:sup>+\/\u2013<\/jats:sup>\n                      mice. Interestingly, myocardial NE content decreased after EA in WT and \u03b2\n                      <jats:sub>1<\/jats:sub>\n                      -AR\n                      <jats:sup>+\/\u2013<\/jats:sup>\n                      mice.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      EA may enhance cardiac function and reduced MI area\/apoptosis by restoring the activity of \u03b2\n                      <jats:sub>1<\/jats:sub>\n                      -AR and post-receptor PKA signaling.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09645284241298716","type":"journal-article","created":{"date-parts":[[2024,11,23]],"date-time":"2024-11-23T06:52:11Z","timestamp":1732344731000},"page":"342-355","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Electroacupuncture alleviates acute myocardial ischemic injury in mice by regulating the \u03b2\n                    <sub>1<\/sub>\n                    adrenergic receptor and post-receptor protein kinase A signaling pathway"],"prefix":"10.1177","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4396-9201","authenticated-orcid":false,"given":"Haiyan","family":"Zuo","sequence":"first","affiliation":[{"name":"Institute of Acupuncture and Meridian, Anhui University of Chinese Medicine, Hefei, China"},{"name":"Anhui Province Key Laboratory of Meridian Viscera Correlationship, Anhui University of Chinese Medicine, Hefei, 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