{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:40:39Z","timestamp":1791488439375,"version":"4.3.4"},"reference-count":44,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:00:00Z","timestamp":1748390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Research Project of Health Commission of Sichuan Province, China","award":["17ZDYF1814"],"award-info":[{"award-number":["17ZDYF1814"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acupunct Med"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>\n                      To investigate the effects of different frequencies of electroacupuncture (EA) stimulation on the electroencephalogram (EEG) and intracranial levels of adenosine (Ad) and prostaglandin D\n                      <jats:sub>2<\/jats:sub>\n                      (PGD\n                      <jats:sub>2<\/jats:sub>\n                      ) in rats anesthetized using propofol.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Thirty-six rats were divided into the manual acupuncture (MA), high-frequency EA (HF-EA) and low-frequency EA (LF-EA) groups (n\u2009=\u200912\/group). After intravenous anesthesia with propofol, an EEG was recorded before and after stimulation at bilateral ST36 and PC6 using 50-Hz stimulation (HF-EA group) or 2\/15-Hz stimulation (LF-EA group) versus no electrical stimulation (MA group). The brains were collected after the experiment to determine cortical and subcortical Ad and PGD\n                      <jats:sub>2<\/jats:sub>\n                      levels. The ventrolateral preoptic nucleus (VLPO) was collected for Ad immunohistochemistry.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      There were changes in the \u03b4 wave in the LF-EA group and in the \u03b1, \u03b2 and \u03b8 waves in the HF-EA group. Compared with the MA group, subcortical Ad levels were higher in the LF-EA group (0.96\u2009\u00b1\u20090.035 vs 0.93\u2009\u00b1\u20090.034\u2009pmol\/mL, p\u2009&lt;\u20090.05). Cortical PGD\n                      <jats:sub>2<\/jats:sub>\n                      levels were higher in the LF-EA group than in the MA group (13.49\u2009\u00b1\u20090.440 vs 12.95\u2009\u00b1\u20090.436\u2009pmol\/mL, p\u2009&lt;\u20090.05). VLPO Ad levels were significantly increased in the LF-EA group compared to both the HF-EA group (0.210\u2009\u00b1\u20090.0066 vs 0.201\u2009\u00b1\u20090.0065, p\u2009&lt;\u20090.05) and the MA group (0.210\u2009\u00b1\u20090.0066 vs 0.199\u2009\u00b1\u20090.0095, p\u2009&lt;\u20090.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      LF-EA at bilateral ST36 and PC6 may increase the depth of anesthesia and sedation, possibly through increased intracranial PGD\n                      <jats:sub>2<\/jats:sub>\n                      and Ad levels. However, such an effect was not found with HF-EA.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09645284251344329","type":"journal-article","created":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T00:50:27Z","timestamp":1748479827000},"page":"174-180","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of different frequencies of electroacupuncture stimulation on the electroencephalogram and intracranial levels of prostaglandin D\n                    <sub>2<\/sub>\n                    and adenosine in rats under propofol anesthesia"],"prefix":"10.1177","volume":"43","author":[{"given":"Qing","family":"Chai","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinjun","family":"Shu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaiming","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiquan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuying","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangchun","family":"Yan","sequence":"additional","affiliation":[{"name":"Sichuan Academy of Chinese Medicine Sciences, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Song","sequence":"additional","affiliation":[{"name":"Sichuan Academy of Chinese Medicine Sciences, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Acupuncture, Chengdu First People\u2019s Hospital, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4598-4907","authenticated-orcid":false,"given":"Yiding","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,5,28]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2016.09.013"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.8907"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/acupmed-2011-010095"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(97)00394-6"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/acupmed-2014-010594"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/0300060517705539"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3999(89)90010-X"},{"key":"e_1_3_3_9_2","first-page":"35","volume-title":"Scientific Bases of Acupuncture","author":"Pomeranz B.","year":"1987","unstructured":"Pomeranz B. 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