{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T17:02:14Z","timestamp":1791133334950,"version":"4.1.0"},"reference-count":36,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,7,13]],"date-time":"2025-07-13T00:00:00Z","timestamp":1752364800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Medical Health Science and Technology Development Plan Project of Shandong Province","award":["2019WS572"],"award-info":[{"award-number":["2019WS572"]}]},{"name":"Traditional Chinese Medicine Technology Development Project of Shandong Province, China","award":["M-2022162"],"award-info":[{"award-number":["M-2022162"]}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2020QH314"],"award-info":[{"award-number":["ZR2020QH314"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82104937"],"award-info":[{"award-number":["82104937"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82305322"],"award-info":[{"award-number":["82305322"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Key Research and Development Plan Project of China","award":["2019YFC1710200"],"award-info":[{"award-number":["2019YFC1710200"]}]},{"name":"National Key Research and Development Plan Project of China","award":["2021YFC2702103"],"award-info":[{"award-number":["2021YFC2702103"]}]},{"name":"Integrated Chinese and Western Medicine Specialised Disease Prevention and Treatment Project of Shandong Province","award":["YXH2019ZXY001"],"award-info":[{"award-number":["YXH2019ZXY001"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acupunct Med"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To investigate the effects of manual acupuncture (MA) on the signal transduction and activator of transcription (STAT)3 \u2013 matrix metalloproteinase (MMP)-2 pathway in a guinea pig model of lens-induced myopia (LIM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      A total of 36 male pigmented guinea pigs (aged 2\u2009weeks) were randomly assigned to the normal control (NC) (n\u2009=\u200912), LIM (n\u2009=\u200912) and LIM\u2009+\u2009MA (n\u2009=\u200912) groups. The NC group received no intervention. To create myopia, the right eyes of the LIM and LIM\u2009+\u2009MA groups were covered with \u22126.00 D lenses. The LIM\u2009+\u2009MA group received 30\u2009min of acupuncture stimulation daily at\n                      <jats:italic>Taiyang<\/jats:italic>\n                      and LI4. The effect of LIM modelling and MA on ocular measurements, expression of STAT3, phosphorylated (p)-STAT3, MMP-2 and tissue inhibitor of MMP-2 (TIMP)-2 expression (as well as histopathology, morphology and immunohistochemistry of the guinea pigs\u2019 eyes) were evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Compared with the NC group, the LIM group showed increased expression of STAT3, p-STAT3 and MMP-2, and decreased expression of TIMP-2, as well as an increase in ocular measurements. The eye tissue morphology was disrupted and fibres became thinner in the LIM group. Compared to the LIM group, the LIM\u2009+\u2009MA group exhibited a noteworthy decline in the expression of STAT3, p-STAT3 and MMP-2, a significant increase in TIMP-2, and a decrease in ocular measurements and tissue morphology, which were similar to that of the NC group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Acupuncture has the potential to decrease STAT3 activation and block the STAT3-MMP-2 pathway in the ocular tissue of guinea pigs with experimental LIM, thereby delaying the development of myopia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09645284251345847","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T05:52:41Z","timestamp":1752472361000},"page":"208-217","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Acupuncture blocks the STAT3-MMP-2 pathway in a guinea pig model of lens-induced myopia"],"prefix":"10.1177","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1362-8791","authenticated-orcid":false,"given":"Yu-Hui","family":"Zhao","sequence":"first","affiliation":[{"name":"College of Ophthalmology and Optometry, Shandong University of Traditional Chinese Medicine, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu-Zhen","family":"Lu","sequence":"additional","affiliation":[{"name":"College of Ophthalmology and Optometry, Shandong University of Traditional Chinese Medicine, Jinan, China"},{"name":"Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine, Shandong Academy of Eye Disease Prevention and Therapy, Shandong Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases, Jinan, 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Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing-Bo","family":"He","sequence":"additional","affiliation":[{"name":"College of Ophthalmology and Optometry, Shandong University of Traditional Chinese Medicine, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua-Yue","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Ophthalmology and Optometry, Shandong University of Traditional Chinese Medicine, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao-Hui","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Ophthalmology and Optometry, Shandong University of Traditional Chinese Medicine, Jinan, 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Hospital of Shandong University of Traditional Chinese Medicine, Shandong Academy of Eye Disease Prevention and Therapy, Shandong Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,7,13]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.94826"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2020.07.034"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2021.720514"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-00231-4"},{"key":"e_1_3_3_6_2","unstructured":"The Disease Control Prevention Bureau of the National Health Commission of China. 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