{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:57:13Z","timestamp":1777381033314,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acupunct Med"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p content-type=\"TEXT\">Electroacupuncture (EA) accelerates repair of peripheral nerve injury. The aim of this study was to explore how EA regulates energy metabolism by examining its effects on glucose transport and mitochondrial dynamic balance in a rat model of sciatic nerve injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p content-type=\"TEXT\">In experiment 1, expression of glucose transporter (GLUT)4 was measured in n\u2009=\u200916 rats at 1, 3, 5 and 7\u2009days following EA to identify the optimal glucose uptake time. In experiment 2, n\u2009=\u200932 rats were randomly divided into the following four groups: Normal, Injury, EA and ES (electrical stimulation). Three days after sciatic nerve injury modeling, micro-positron emission tomography\/computed tomography (PET\/CT) was performed to observe glucose uptake in the sciatic nerve and surrounding tissues. After 1\u2009week, we measured nerve conduction velocity and expression of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), mitofusin (Mfn)1\/2 and dynamin-related protein (Drp)1 in the sciatic nerve (by Western blotting) and observed pathological changes in the sciatic nerve and gastrocnemius.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p content-type=\"TEXT\">Protein expression levels of GLUT4, Mfn1\/2 and Drp1 were significantly higher in the EA group, and histopathological changes were improved, compared with other groups. Glucose uptake by micro-PET\/CT in the target area in the EA group was significantly higher than that in the other groups. Furthermore, nerve conduction velocity and NGF\/BDNF expression was significantly higher in the EA group compared with the other three groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p content-type=\"TEXT\">EA accelerated the repair and regeneration of the injured sciatic nerve, activated glucose transport and improved mitochondrial dynamic balance, in a rat model.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09645284251399240","type":"journal-article","created":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T11:38:06Z","timestamp":1764589086000},"page":"354-364","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Electroacupuncture promotes functional recovery and activates energy metabolism in a rat model of sciatic nerve injury"],"prefix":"10.1177","volume":"43","author":[{"given":"Jian-lan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Traditional Chinese Medicine, Central Hospital of Dalian University of Technology, Dalian, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"An","sequence":"additional","affiliation":[{"name":"Department of Trauma and Orthopedics, Ningbo No. 6 Hospital, Ningbo, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-hong","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Central Hospital of Dalian University of Technology, Dalian, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Central Hospital of Dalian University of Technology, Dalian, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Hand Microsurgery, The First Affiliated Hospital of Dalian Medical University, Dalian, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Central Hospital of Dalian University of Technology, Dalian, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9844-423X","authenticated-orcid":false,"given":"Yu-xuan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Central Hospital of Dalian University of Technology, Dalian, China"},{"name":"Department of Hand Microsurgery, The First Affiliated Hospital of Dalian Medical University, Dalian, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,12]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21228652"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.24538"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/7530102"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2022.1065557"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2017.07.024"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/3755439"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2021.12.013"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000506483"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/3849441"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00030.2008"},{"issue":"2","key":"e_1_3_2_12_2","first-page":"871","article-title":"Profiling of the dynamically altered gene expression in peripheral nerve injury using NGS RNA sequencing technique","volume":"8","author":"Han D","year":"2016","unstructured":"Han D, Chen Y, Kou Y, et al. Profiling of the dynamically altered gene expression in peripheral nerve injury using NGS RNA sequencing technique. Am J Transl Res 2016; 8(2): 871\u2013884.","journal-title":"Am J Transl Res"},{"issue":"4","key":"e_1_3_2_13_2","first-page":"1054","article-title":"Expression of transforming growth factor beta in peripheral nerve crushed injury","volume":"12","author":"Wang D.","year":"2000","unstructured":"Wang D. Expression of transforming growth factor beta in peripheral nerve crushed injury. 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