{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T06:05:20Z","timestamp":1784700320817,"version":"3.55.0"},"reference-count":25,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:00:00Z","timestamp":1773619200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["202300410262"],"award-info":[{"award-number":["202300410262"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973822"],"award-info":[{"award-number":["81973822"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82074406"],"award-info":[{"award-number":["82074406"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acupunct Med"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Electroacupuncture (EA) has shown efficacy in the treatment of chronic obstructive pulmonary disease (COPD), but the underlying mechanism of action remains unclear. Oxidative stress is a main pathological process in COPD. This aim of this study was to explore the anti-oxidant effect of EA in a COPD rat model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Rats were divided into control, model, EA, sham acupuncture (SA) and N-acetylcysteine (NAC) groups. All rats except those in the control group were exposed to cigarette smoke combined with repeated bacterial infection to induce a COPD rat model. Rats in the EA group received EA at GV14 and bilateral BL13\/BL23 for a further 8\u2009weeks, while rats in SA group were given manual acupuncture at sites 5\u2009mm from the traditional acupuncture point locations (without electrical stimulation) as a negative control. NAC (54\u2009mg\/kg\/d) was used in the NAC group as a positive control. Lung function was assessed by whole body plethysmography, and tissue structure was assessed by histology. mRNA and protein levels of oxidative indicators and nuclear factor E2-related factor (Nrf2) signaling were measured by qPCR and immunohistochemistry or Western blotting, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>After EA treatment, lung function and pathological features were improved. Total antioxidant capacity (T-AOC) and total superoxide dismutase (T-SOD) in serum, as well as SOD1 and heme oxygenase (HO)-1 in lung tissue, were increased, while markers of oxidative stress\u2014lipid peroxidation (LPO) and malonaldehyde activity (MDA)\u2014were decreased. Nrf2 protein in the nucleus of lung tissue, as well as HO-1 and \u03b3-glutamylcysteine synthetase (\u03b3-GCS) mRNA and protein, were improved. NAC, as an antioxidant, was better than EA at increasing the expression of HO-1 protein and \u03b3-GCS mRNA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>EA was beneficial for the treatment of COPD in this rat model and exerted antioxidant effects via mechanisms potentially related to Nrf2 signaling.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09645284261424261","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T05:46:36Z","timestamp":1773726396000},"page":"210-221","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Electroacupuncture mitigates lung injury, increases endogenous antioxidant levels and modulates Nrf2 signaling in a rat model of chronic obstructive pulmonary disease"],"prefix":"10.1177","volume":"44","author":[{"given":"Yange","family":"Tian","sequence":"first","affiliation":[{"name":"Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases co-constructed by Henan Province &amp; Education Ministry of P.R., Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Henan University of Chinese Medicine, Zhengzhou, China"},{"name":"Academy of Chinese Medicine Sciences, Henan University of Chinese Medicine, Zhengzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4018-0117","authenticated-orcid":false,"given":"Lanxi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases co-constructed by Henan Province &amp; Education Ministry of P.R., Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Henan University of Chinese Medicine, Zhengzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases co-constructed by Henan Province &amp; Education Ministry of P.R., Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Henan University of Chinese Medicine, Zhengzhou, China"},{"name":"Academy of Chinese Medicine Sciences, Henan University of Chinese Medicine, Zhengzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefang","family":"Liu","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases co-constructed by Henan Province &amp; Education Ministry of P.R., Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Henan University of Chinese Medicine, Zhengzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanli","family":"Jin","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases co-constructed by Henan Province &amp; Education Ministry of P.R., Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Henan University of Chinese Medicine, Zhengzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases co-constructed by Henan Province &amp; Education Ministry of P.R., Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Henan University of Chinese Medicine, Zhengzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiansheng","family":"Li","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases co-constructed by Henan Province &amp; Education Ministry of P.R., Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Henan University of Chinese Medicine, Zhengzhou, China"},{"name":"The First Affiliated Hospital, Henan University of Chinese Medicine, Zhengzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,3,16]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis management and prevention of Chronic Obstructive Pulmonary Disease (GOLD REPORTS [EB\/OL]) 2021. http:\/\/www.goldcopd.org"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30105-3"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30841-9"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101544"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-021-00233-1"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00449.2016"},{"key":"e_1_3_3_8_2","article-title":"Role of Nrf2 and its activators in respiratory diseases","volume":"2019","author":"Liu Q","year":"2019","unstructured":"Liu Q, Gao Y, Ci X. Role of Nrf2 and its activators in respiratory diseases. 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