{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:05:20Z","timestamp":1790762720354,"version":"4.1.0"},"reference-count":30,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Jiangsu Provincial Cadre Healthcare Bureau Project","award":["BJ23018"],"award-info":[{"award-number":["BJ23018"]}]},{"DOI":"10.13039\/501100007289","name":"nanjing medical university","doi-asserted-by":"publisher","award":["501100007289"],"award-info":[{"award-number":["501100007289"]}],"id":[{"id":"10.13039\/501100007289","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acupunct Med"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This aim of the study was to investigate whether electroacupuncture (EA) can mitigate osteoporosis (OP) in an ovariectomy (OVX)-induced rat model by affecting the ferroptosis-related pathway.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Thirty-two 12-week-old female Sprague-Dawley rats were randomly allocated into four groups: CONTROL, SHAM, OVX and EA. We examined the effects of OVX and EA on markers of bone resorption and formation, iron content, malondialdehyde (MDA) levels, and the expression of ferritin heavy chain 1 (FTH1), solute carrier family 7 member 11 (SLC7A11) and glutathione peroxidase 4 (GPX4). In addition, femoral morphology and immunofluorescence were analysed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The OVX group exhibited a significant increase in bone resorption markers, iron and MDA levels, with a notable decrease in alkaline phosphatase (ALP) levels, FTH1, SLC7A11 and GPX4 expression, and impaired trabecular architecture. EA significantly reduced bone resorption markers, iron and MDA content while substantially elevating ALP levels and FTH1, SLC7A11 and GPX4 expression. At the same time, EA improved trabecular architecture.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>EA ameliorated OVX-induced OP by decreasing iron accumulation and activating the SLC7A11\/GPX4 axis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09645284261454388","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T09:53:47Z","timestamp":1783331627000},"page":"288-297","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Electroacupuncture ameliorates ovariectomy-induced osteoporosis by modulating ferroptosis via the SLC7A11\/GPX4 axis"],"prefix":"10.1177","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-9506-2210","authenticated-orcid":false,"given":"Chuchu","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Acupuncture-Moxibustion and Tuina, Nanjing University of Chinese Medicine, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0939-6100","authenticated-orcid":false,"given":"Gang","family":"Ouyang","sequence":"additional","affiliation":[{"name":"School of Acupuncture-Moxibustion and Tuina, Nanjing University of Chinese Medicine, Nanjing, China"},{"name":"Department of Acupuncture and Moxibustion, Jiangsu Province Geriatric Hospital, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,6]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-021-02772-0"},{"key":"e_1_3_3_3_2","unstructured":"International Osteoporosis Foundation. Facts and Statistics. International Osteoporosis Foundation 2024 https:\/\/www.osteoporosis.foundation\/facts-statistics (accessed 30 October 2025)."},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.882241"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-023-1971-4"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22073553"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22041568"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu2070693"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/1759720X17732562"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15024"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2025.1561344"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2025.1483819"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1159\/000541440"},{"key":"e_1_3_3_14_2","first-page":"8574621","article-title":"The efficacy and safety of acupuncture for treating Osteoporotic Vertebral Compression Fracture- (OVCF-) induced pain: a systematic review and meta-analysis of randomised clinical trials","volume":"2021","author":"Li JL","year":"2021","unstructured":"Li JL, Rong S, Zhou Z, et al. The efficacy and safety of acupuncture for treating Osteoporotic Vertebral Compression Fracture- (OVCF-) induced pain: a systematic review and meta-analysis of randomised clinical trials. Evid Based Complement Alternat Med 2021; 2021: 8574621.","journal-title":"Evid Based Complement Alternat Med"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2015.2553"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.4849"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/acupmed-2012-010271"},{"issue":"4","key":"e_1_3_3_18_2","first-page":"3453","article-title":"Mechanisms by which electroacupuncture-mediated histone acetylation mitigates bone loss in rats with ovariectomy-induced osteoporosis","volume":"22","author":"Shu Q","year":"2020","unstructured":"Shu Q, Shao Y, Liu R, et al. Mechanisms by which electroacupuncture-mediated histone acetylation mitigates bone loss in rats with ovariectomy-induced osteoporosis. Mol Med Rep 2020; 22(4): 3453\u20133463.","journal-title":"Mol Med Rep"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000039158"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.06.003"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-024-01564-3"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.590226"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.155282"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.70368"},{"issue":"9","key":"e_1_3_3_25_2","first-page":"979","article-title":"Effect of Lingnan Chen\u2019s acupuncture on postmenopausal osteoporosis and serum GH and IGF-1","volume":"42","author":"Chen YT","year":"2022","unstructured":"Chen YT, Lin LM, Wang XD, et al. Effect of Lingnan Chen\u2019s acupuncture on postmenopausal osteoporosis and serum GH and IGF-1. Zhongguo Zhen Jiu 2022; 42(9): 979\u2013984 (Chinese).","journal-title":"Zhongguo Zhen Jiu"},{"issue":"4","key":"e_1_3_3_26_2","first-page":"391","article-title":"Effect of combining Shu-Mu and Shaoyang meridian acupoints on bone metabolism in osteoporosis","volume":"42","author":"Tian CY","year":"2023","unstructured":"Tian CY, Yang JJ, Dao YT, et al. Effect of combining Shu-Mu and Shaoyang meridian acupoints on bone metabolism in osteoporosis. Shanghai Zhen Jiu Za Zhi 2023; 42(4): 391\u2013394 (Chinese).","journal-title":"Shanghai Zhen Jiu Za Zhi"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.1074516"},{"issue":"1","key":"e_1_3_3_28_2","first-page":"113","article-title":"Efficacy of suspended moxibustion stimulating Shenshu (BL23) and Guanyuan (CV4) on the amygdala-HPA axis in rats with kidney-deficiency symptom pattern induced by hydrocortisone","volume":"43","author":"Youjiang M","year":"2023","unstructured":"Youjiang M, Haihua Y, Zhiqin W, et al. 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