{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:02:18Z","timestamp":1790776938618,"version":"4.1.0"},"reference-count":9,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100022600","name":"Wan Fang Hospital","doi-asserted-by":"publisher","award":["N202204036"],"award-info":[{"award-number":["N202204036"]}],"id":[{"id":"10.13039\/501100022600","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acupunct Med"],"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To investigate the association between acupuncture and 5-year cholecystectomy rate, alongside hepatorenal function preservation, in a large-scale real-world cohort of patients with biliary disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A retrospective cohort study was conducted using the TriNetX US Collaborative Network. After 1:1 propensity score matching, 7930 patients who had received manual acupuncture were compared with 7930 matched controls. The primary outcome was 5-year cumulative cholecystectomy rate, assessed by Kaplan\u2013Meier analysis and risk ratio.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>After matching, all baseline covariates achieved a standardized mean difference below 0.1. The acupuncture group demonstrated significantly lower 5-year cumulative cholecystectomy rate (7.585% vs 13.454%; risk ratio: 0.564, 95% confidence interval: 0.511\u20130.622; hazard ratio: 0.525, 95% confidence interval: 0.473\u20130.582; p\u2009&lt;\u20090.0001). Acupuncture was also associated with significantly lower risk across all seven secondary outcomes, including markers of systemic inflammation, cholestasis, and hepatorenal impairment (all p\u2009&lt;\u20090.0001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In this large-scale propensity score\u2013matched cohort, manual acupuncture was significantly associated with reduced 5-year cholecystectomy rate and preservation of hepatobiliary and renal function in patients with biliary disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09645284261484972","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T09:55:46Z","timestamp":1790589346000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Acupuncture is associated with reduced cholecystectomy rate and preservation of hepatobiliary and renal function in biliary disorders: A propensity score-matched real-world cohort study"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1019-8006","authenticated-orcid":false,"given":"Chao-Yang","family":"Chen","sequence":"first","affiliation":[{"name":"Hubei University of Chinese Medicine, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung-Kai","family":"Hung","sequence":"additional","affiliation":[{"name":"Taipei Medical University-Shuang Ho Hospital, Ministry of Health and Welfare"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He-Yuan","family":"Shi","sequence":"additional","affiliation":[{"name":"Hubei University of Chinese Medicine, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Luo","sequence":"additional","affiliation":[{"name":"Beijing University of Chinese Medicine, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung-Yu","family":"Huang","sequence":"additional","affiliation":[{"name":"Taipei Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4147-0960","authenticated-orcid":false,"given":"Kuo-Sheng","family":"Hung","sequence":"additional","affiliation":[{"name":"Taipei Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"crossref","unstructured":"Yin Z Xiao Q Xu G et al. Acupuncture for the postcholecystectomy syndrome: a systematic review and meta-analysis. Evid Based Complement Alternat Med 2020; 2020: 7509481. https:\/\/doi.org\/10.1155\/2020\/7509481","DOI":"10.1155\/2020\/7509481"},{"key":"e_1_3_3_3_2","doi-asserted-by":"crossref","unstructured":"Diehl DL. Acupuncture for gastrointestinal and hepatobiliary disorders. J Altern Complement Med 1999; 5(1): 27\u201345. https:\/\/doi.org\/10.1089\/acm.1999.5.27","DOI":"10.1089\/acm.1999.5.27"},{"issue":"3","key":"e_1_3_3_4_2","first-page":"1","article-title":"Acupuncture and biliary function regulation: a mini-review","volume":"9","author":"Zhang Y","year":"2022","unstructured":"Zhang Y, Zhou Q, Liu J, et al. Acupuncture and biliary function regulation: a mini-review. Jpn J Gastroenterol Hepatol 2022; 9(3): 1\u20137.","journal-title":"Jpn J Gastroenterol Hepatol"},{"key":"e_1_3_3_5_2","doi-asserted-by":"crossref","unstructured":"Sun N He DM Ye X et al. Immediate acupuncture with GB34 for biliary colic: protocol for a randomised controlled neuroimaging trial. BMJ Open 2022; 12(1): e050413. https:\/\/doi.org\/10.1136\/bmjopen-2021-050413","DOI":"10.1136\/bmjopen-2021-050413"},{"key":"e_1_3_3_6_2","volume-title":"US collaborative network (Database)","author":"TriNetX","year":"2026","unstructured":"TriNetX. US collaborative network (Database). TriNetX Inc, 2026."},{"key":"e_1_3_3_7_2","doi-asserted-by":"crossref","unstructured":"VanderWeele TJ Ding P. Sensitivity analysis in observational research: introducing the E-value. Ann Intern Med 2017; 167(4): 268\u2013274. https:\/\/doi.org\/10.7326\/M16-2607","DOI":"10.7326\/M16-2607"},{"key":"e_1_3_3_8_2","doi-asserted-by":"crossref","unstructured":"Hao M Dou Z Xu L et al. RNA sequencing analysis of gene expression by electroacupuncture in guinea pig gallstone models. Evid Based Complement Alternat Med 2022; 2022: 3793946. https:\/\/doi.org\/10.1155\/2022\/3793946","DOI":"10.1155\/2022\/3793946"},{"key":"e_1_3_3_9_2","doi-asserted-by":"crossref","unstructured":"Aleid A Alhebshi ZA Alhazmi ES et al. Assessing the impact of laparoscopic cholecystectomy on satisfaction quality of life and cost-effectiveness in Saudi patients with gallstone disease. Cureus 2023; 15(9): e45288. https:\/\/doi.org\/10.7759\/cureus.45288","DOI":"10.7759\/cureus.45288"},{"key":"e_1_3_3_10_2","doi-asserted-by":"crossref","unstructured":"Miranda LE Filho LFMES Siqueira ACB et al. Effect of acupuncture on the prevention of nausea and vomiting after laparoscopic cholecystectomy: a randomized clinical trial. Braz J Anesthesiol 2020; 70(5): 520\u2013526. https:\/\/doi.org\/10.1016\/j.bjan.2019.08.001","DOI":"10.1016\/j.bjane.2019.08.001"}],"container-title":["Acupuncture in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09645284261484972","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09645284261484972","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09645284261484972","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:50:52Z","timestamp":1790776252000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09645284261484972"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,28]]},"references-count":9,"alternative-id":["10.1177\/09645284261484972"],"URL":"https:\/\/doi.org\/10.1177\/09645284261484972","relation":{},"ISSN":["0964-5284","1759-9873"],"issn-type":[{"value":"0964-5284","type":"print"},{"value":"1759-9873","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,28]]},"article-number":"09645284261484972"}}