{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T05:37:54Z","timestamp":1740893874068,"version":"3.38.0"},"reference-count":25,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2002,6,1]],"date-time":"2002-06-01T00:00:00Z","timestamp":1022889600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovascular Surgery"],"published-print":{"date-parts":[[2002,6]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> Prosthetic cardiac valves have increased life expectancy of patients (pts) with valvular heart disease. Bioprosthetic complications required devices replacements within 10 years of implantation; structural valve deterioration (SVD) has emerged as the major cause of reoperation. We reviewed survival and prosthetic complications of Biocor porcine bioprostheses implanted in mitral, aortic and mitro-aortic position. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> Between January 1991 and January 2001 446 pts (192 males; 254 females; mean age 73.4\u00b16.7 year, range 40\u201391) received 258 aortic, 138 mitral and 50 mitro-aortic Biocor porcine valves; of these 83 pts have previous different types of prosthetic devices (15 aortic, 53 mitral and 15 double). Concomitant cardiac procedures, namely myocardial revascularization, were performed in 91\/446 pts (20.5%). All explanted bioprostheses (BPS) were available for pathologic investigation. Follow-up included 1319 pt.-years and was 98% complete with a median time of 36 pt.-months. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> Perioperative mortality was 6.8% (30\/446 pts; 12 aortic, 17 mitral and 1 double) and was mostly related to reoperations. At the end of follow-up 18.5% of pts died (77\/416), 12 deaths were valve-related with freedom from valve related mortality of 94% at 9 years. Survival was 54% at 9 years. It was 63%, 41% and 62% for aortic, mitral and double valve replacement, respectively. At follow-up 87% of pts. were in NYHA I\u2014II class and 13% were in III\u2014IV class; 55% were in sinus rhythm, 36% in atrial fibrillation and 9% had a pace-maker. Eighty-five percent of pts were anticoagulated. There were 6 thromboembolic and 5 anticoagulant-related haemorrhagic episodes with no significant difference between aortic and mitral position ( p=0.7). The event freeedom was respectively 92% and 98.5% at 9 years. Prosthetic valve endocarditis (PVE) and non-SVD freedom were 96% and 93% at 9 years. SVD due to tissue degeneration, calcification and cusp's tears affected 2 pts with 94% freedom at 9 years. Overall freedom from all valve-related complications was 80% at 9 years and freedom from reoperation was 92% at 9 years. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p> (1) Our intermediate-term follow-up of the Biocor porcine valve (BPS) showed excellent durability in all positions. (2) The aortic patients and especially the oldest group had better results than the mitral patients (41% vs. 63% 9 years survival, p=0.0004). (3) Higher mitral risk was related to higher prevalence of reoperations. (4) The incidence of anticoagulation-related complications is low in both aortic and mitral position without significant difference ( p=0.7). 4) A longer follow-up is required to get more information about SVD timing. <\/jats:p><\/jats:sec>","DOI":"10.1177\/096721090201000310","type":"journal-article","created":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T13:05:34Z","timestamp":1663074334000},"page":"238-244","source":"Crossref","is-referenced-by-count":1,"title":["Mid-Term Follow-Up in Patients with Biocor Porcine Bioprostheses"],"prefix":"10.1177","volume":"10","author":[{"given":"Tomaso","family":"Bottio","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, University of Padua Medical School, Padua, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulio","family":"Rizzoli","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University of Padua Medical School, Padua, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gino","family":"Gerosa","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University of Padua Medical School, Padua, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaetano","family":"Thiene","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Pathology, University of Padua Medical School, Padua, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dino","family":"Casarotto","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University of Padua Medical School, Padua, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2002,6,1]]},"reference":[{"key":"bibr1-096721090201000310","doi-asserted-by":"publisher","DOI":"10.1378\/chest.83.4.607"},{"key":"bibr2-096721090201000310","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)37768-2"},{"key":"bibr3-096721090201000310","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(95)00255-J"},{"key":"bibr4-096721090201000310","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820240611"},{"key":"bibr5-096721090201000310","first-page":"3","volume":"96","author":"Edmunds L. H. J.","year":"1998","journal-title":"J. Thorac. Cardiovasc. Surg"},{"key":"bibr6-096721090201000310","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8651(18)30298-4"},{"key":"bibr7-096721090201000310","first-page":"1","volume":"1","author":"Schoen F. J.","year":"1992","journal-title":"CVP"},{"key":"bibr8-096721090201000310","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(96)00629-7"},{"key":"bibr9-096721090201000310","first-page":"81","volume":"3","author":"Boltolotti U.","year":"1994","journal-title":"J. Heart Valve Dis"},{"key":"bibr10-096721090201000310","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)35024-X"},{"key":"bibr11-096721090201000310","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0003-4975(89)90650-4","volume":"48","author":"Jamieson W. R. E.","year":"1989","journal-title":"Ann. Thorac. Surg"},{"key":"bibr12-096721090201000310","first-page":"82","volume":"4","author":"Akins C. 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Heart Valve Dis"},{"key":"bibr19-096721090201000310","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(80)90421-X"},{"key":"bibr20-096721090201000310","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)39217-7"},{"key":"bibr21-096721090201000310","first-page":"415","volume":"9","author":"Myken P.","year":"2000","journal-title":"J. Heart Valve Dis"},{"key":"bibr22-096721090201000310","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)90014-0"},{"key":"bibr23-096721090201000310","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(92)91008-W"},{"key":"bibr24-096721090201000310","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)36440-2"},{"key":"bibr25-096721090201000310","first-page":"4","volume":"8","author":"Butany J.","year":"1999","journal-title":"J. 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