{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T10:47:09Z","timestamp":1792493229098,"version":"4.5.0"},"reference-count":26,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2003,4,1]],"date-time":"2003-04-01T00:00:00Z","timestamp":1049155200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovascular Surgery"],"published-print":{"date-parts":[[2003,4]]},"abstract":"<jats:p> The purpose of our study was to evaluate the clinical outcome of postinfarction ventricular septal defect (VSD) of patients referred to our institution for surgical treatment, by assessing the role of several operative, pre- and post-operative variables on mortality. <\/jats:p><jats:p> The medical records of 58 consecutive patients (mean age 73\u00b17 years), operated on after 14\u00b112 days from the acute myocardial infarction were retrospectively reviewed and the data were analyzed. Associated procedures were left ventricular reconstruction in 13 patients and aortocoronary bypass grafting in 47 (81%). <\/jats:p><jats:p> The overall operative, in-hospital mortality rate was 52% (75% in patients operated on within the first week and 16% if time from infarct to surgery was &gt;3 weeks). Time from AMI to surgery and time from hospital admission to operation were significantly shorter in nonsurvivors ( p=0.003 and 0.012, respectively). Other pre-operative variables significantly associated with mortality were: cardiogenic shock, pulmonary pressure, VSD diameter. <\/jats:p><jats:p> In conclusion, time from AMI to operation appears to be a very important prognostic factor. However, size of VSD and hemodynamic conditions significantly influence the mortality. Moreover, concomitant procedures of revascularization can be safely performed, when required, as actually occurs in most cases. <\/jats:p>","DOI":"10.1177\/096721090301100208","type":"journal-article","created":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T13:06:55Z","timestamp":1663074415000},"page":"149-154","source":"Crossref","is-referenced-by-count":17,"title":["Surgical Treatment of Ventricular Septal Defect Complicating Acute Myocardial Infarction. Experience of a North Italian Referral Hospital"],"prefix":"10.1177","volume":"11","author":[{"given":"G.","family":"Cerin","sequence":"first","affiliation":[{"name":"Department of Cardiology, Istituto Policlinico San Donato, E. Malan Cardiovascular Center, University of Milan, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Di","family":"Donato","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, University of Florence, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Dimulescu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital, Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Montericcio","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Istituto Policlinico San Donato, E. Malan Cardiovascular Center, University of Milan, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Menicanti","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Istituto Policlinico San Donato, E. Malan Cardiovascular Center, University of Milan, Milan, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Frigiola","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Istituto Policlinico San Donato, E. Malan Cardiovascular Center, University of Milan, Milan, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"De Ambroggi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Istituto Policlinico San Donato, E. Malan Cardiovascular Center, University of Milan, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2003,4,1]]},"reference":[{"key":"bibr1-096721090301100208","unstructured":"Kirklin J. W. and Barratt-Boyes B. G. Postinfarction ventricular septal defect. In Cardiac Surgery Churchill Livingstone, New York 1993, pp. 403\u2013114."},{"key":"bibr2-096721090301100208","first-page":"497","volume":"85","author":"Pretre R.","year":"2000","journal-title":"Frequency of collateral blood flow in the infarct-related coronary-artery in rupture of the ventricular septum after acute myocardial infarction"},{"key":"bibr3-096721090301100208","first-page":"644","volume":"129","author":"Cheriex E. C.","year":"1995","journal-title":"Myocardial rupture after myocardial infarction is related to the perfusion status of the infarct-related coronary artery"},{"key":"bibr4-096721090301100208","first-page":"128","volume":"10","author":"Landzberg M. J.","year":"1998","journal-title":"Transcatheter management of ventricular septal rupture after myocardial infarction"},{"key":"bibr5-096721090301100208","first-page":"322","volume":"14","author":"Chessa M.","year":"2002","journal-title":"Transcatheter closure of congenital and acquired muscular ventricular septal defects using the Amplatzer device"},{"key":"bibr6-096721090301100208","first-page":"330","volume":"25","author":"Ellis C. J.","year":"1995","journal-title":"Good long-term outcome following surgical repair of post-infarction ventricular septal defect"},{"key":"bibr7-096721090301100208","first-page":"105","volume":"10","author":"David T. E.","year":"1998","journal-title":"Surgical repair of postinfarction ventricular septal defect by infarct exclusion"},{"key":"bibr8-096721090301100208","first-page":"111","volume":"10","author":"Dalrymple-Hay M. 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GUSTOI Trial Investigators"},{"key":"bibr13-096721090301100208","first-page":"138","volume":"63","author":"Killen D. A.","year":"1997","journal-title":"Early repair of postinfarction ventricular septal rupture"},{"key":"bibr14-096721090301100208","first-page":"93","volume":"10","author":"Chaux A.","year":"1998","journal-title":"Postinfarction ventricular septal defect"},{"key":"bibr15-096721090301100208","first-page":"117","volume":"10","author":"Madsen J. C.","year":"1998","journal-title":"Repair of postinfarction ventricular septal defects"},{"key":"bibr16-096721090301100208","first-page":"1506","volume":"104","author":"Westaby S.","year":"1992","journal-title":"Thrombolysis and post infarction ventricular septal rupture"},{"key":"bibr17-096721090301100208","first-page":"589","volume":"38","author":"Di Summa M.","year":"1997","journal-title":"Ventricular septal rupture after a myocardial infarction: Clinical features and long term survival"},{"key":"bibr18-096721090301100208","first-page":"1444","volume":"70","author":"Blanche C.","year":"2000","journal-title":"Postinfarction ventricular septal defect in the elderly: Analysis and results"},{"key":"bibr19-096721090301100208","first-page":"298","volume":"12","author":"Dalrymple-Hay M. J. R.","year":"1997","journal-title":"Surgical treatment of acquired ventricular septal defects in the elderly"},{"key":"bibr20-096721090301100208","first-page":"1038","volume":"60","author":"Williams D. 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