{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T02:24:07Z","timestamp":1767666247649,"version":"3.38.0"},"reference-count":13,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2003,10,1]],"date-time":"2003-10-01T00:00:00Z","timestamp":1064966400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovascular Surgery"],"published-print":{"date-parts":[[2003,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p> (1) To evaluate the quality of life (QoL) scores, assessed with SF36 and EuroQol (EQ-5D), of long term survivors after mechanical aortic valve replacement (mAVR); (2) to study the association of QoL with NYHA score, number of major bleeding and thrombo-embolic events and follow-up time; (3) to compare QoL scores of long term mAVR survivors with QoL scores of other populations. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> In total 312 patients had a mAVR between 1964 and 1974 at St. Antonius Hospital Nieuwegein (NL). Mean age at operation was 41 ( sd = 12). Mean postoperative NYHA class at 1-year follow-up was 1.7 ( sd = 0.7). In 2001 the survivors ( n = 78; 25%) were followed-up for late events, NYHA class and QoL scores. 69 patients (93%) returned completed questionnaires. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Mean duration of follow-up was 30 years ( sd = 1.8). Mean age of responders was 65 years ( sd = 10, range 47\u201393). In 2001, NYHA class of responders was 2 ( sd = 0.9). The mean (sd) SF36 scores for responders were: 64 (29) for physical function. 64 (29) for role-physical, 80 (30) for bodily pain. 55 (25) for general health, 63 (23) for vitality. 73 (29) for social functioning, 70 (38) for role-emotional, 76 (18) for mental health. The mean EQ-5D score of responders was: 61 (13). These SF36 and EQ-5D scores are comparable to those of other populations (e.g. cancer, diabetes type-2, migraine, chronic liver disease and iliac artery occlusive disease and Dutch general population). For responders a moderate to high association of SF36 and EQ-5D scores and their NYHA scores(R<jats:sup>2<\/jats:sup> = 0.36) was found. The number of major bleeding events, age, sex and survival time were not related to QoL. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> At long term follow-up (mean 30 years) of patients who had mAVR, QoL was relatively high; it was moderately to highly associated with their NYHA class; bleeding and thromboembolic events seem to be of little importance for the QoL at long term follow-up. QoL at long term follow-up of patients who had mAVR is comparable to other cross sectional designed studies with short term follow-up and other population. <\/jats:p><\/jats:sec>","DOI":"10.1177\/096721090301100509","type":"journal-article","created":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T13:08:05Z","timestamp":1663074485000},"page":"381-387","source":"Crossref","is-referenced-by-count":5,"title":["Quality of Life and NYHA Class 30 Years after Mechanical Aortic Valve Replacement"],"prefix":"10.1177","volume":"11","author":[{"given":"M. A.","family":"Maliwa","sequence":"first","affiliation":[{"name":"Department of Cardio-Thoracic Surgery and \u2018Stichting Hartenzorg\u2019, St Antonius Ziekenhuis, Koekoekslaan 1, 3435 CM Nieuwegein, The Netherlands"},{"name":"Heart Lung Center Utrecht, Utrecht\/Nieuwegein, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. J. M. G.","family":"van der Heijden","sequence":"additional","affiliation":[{"name":"Heart Lung Center Utrecht, Utrecht\/Nieuwegein, The Netherlands"},{"name":"Julius Center for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. L.","family":"Bots","sequence":"additional","affiliation":[{"name":"Julius Center for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. A.","family":"van Hour","sequence":"additional","affiliation":[{"name":"Julius Center for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. P.","family":"Casselman","sequence":"additional","affiliation":[{"name":"Department of Cardio-Thoracic Surgery and \u2018Stichting Hartenzorg\u2019, St Antonius Ziekenhuis, Koekoekslaan 1, 3435 CM Nieuwegein, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"van Swieten","sequence":"additional","affiliation":[{"name":"Department of Cardio-Thoracic Surgery and \u2018Stichting Hartenzorg\u2019, St Antonius Ziekenhuis, Koekoekslaan 1, 3435 CM Nieuwegein, The Netherlands"},{"name":"Heart Lung Center Utrecht, Utrecht\/Nieuwegein, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. E. E.","family":"Vermeulen","sequence":"additional","affiliation":[{"name":"Department of Cardio-Thoracic Surgery and \u2018Stichting Hartenzorg\u2019, St Antonius Ziekenhuis, Koekoekslaan 1, 3435 CM Nieuwegein, The Netherlands"},{"name":"Heart Lung Center Utrecht, Utrecht\/Nieuwegein, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2003,10,1]]},"reference":[{"key":"bibr1-096721090301100509","first-page":"346","volume":"10","author":"Goldsmtih I. R. 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