{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T06:00:14Z","timestamp":1740808814532,"version":"3.38.0"},"reference-count":14,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[1994,12,1]],"date-time":"1994-12-01T00:00:00Z","timestamp":786240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovascular Surgery"],"published-print":{"date-parts":[[1994,12]]},"abstract":"<jats:p> A study was undertaken to compare the two doses of aprotinin and the amount of autologous blood transfused in order to determine the optimal dose of this inhibitor for use in cardiac surgery. A total of 120 patients undergoing elective cardiac surgery from November 1990 to April 1992 took part in this randomized double-blind study. Two groups of 60 patients were treated. Patients in the high-dose group were given the dose of aprotinin recommended by the Hammersmith group (6 million kallikrein inactivator units), the other 60 (the low-dose group) received half the dose. Blood loss from thoracic drains in the postoperative period showed a statistically significant difference between the two groups between 6 and 12 h (a mean loss of 610.9 ml in the low dose). The blood and clotting markers did not differentiate between the high- and low-dose patients. In combination with autologous blood transfusions, a low dose of aprotinin appears as efficient in reducing postoperative blood loss as the high-dose Regimen. <\/jats:p>","DOI":"10.1177\/096721099400200608","type":"journal-article","created":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T19:20:58Z","timestamp":1727119258000},"page":"716-719","source":"Crossref","is-referenced-by-count":5,"title":["Efficacy of Aprotinin in Different Doses and Autologous Blood Transfusions in Cardiac Surgery"],"prefix":"10.1177","volume":"2","author":[{"given":"J.","family":"Gscho\u00dfmann","sequence":"first","affiliation":[{"name":"Department for Cardiovascular Surgery. Augsburg Medical Center\/Zentralklinikum Augsburg. Stenglinstra\u00dfe. D-86156Augsburg. Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Pracki","sequence":"additional","affiliation":[{"name":"Department for Cardiovascular Surgery. Augsburg Medical Center\/Zentralklinikum Augsburg. Stenglinstra\u00dfe. D-86156Augsburg. Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Struck","sequence":"additional","affiliation":[{"name":"Department for Cardiovascular Surgery. Augsburg Medical Center\/Zentralklinikum Augsburg. Stenglinstra\u00dfe. D-86156Augsburg. Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1994,12,1]]},"reference":[{"key":"bibr1-096721099400200608","first-page":"89","volume":"37","author":"Fraedrich G","year":"1989","journal-title":"Reduction of blood transfusion requirement in open heart surgery by administration of high doses of aprotinin - preliminary result"},{"key":"bibr2-096721099400200608","first-page":"533","volume":"3","author":"Wildevuur CRH","year":"1989","journal-title":"Platelet preservation during cardiopulmonary bypass with aprotinin"},{"key":"bibr3-096721099400200608","first-page":"1289","volume":"2","author":"Royston D","year":"1987","journal-title":"Effect of aprotinin on the need for blood transfusion after repeat onen hrart surgury"},{"volume-title":"Aprotinin in cardiovascular surgery","year":"1994","author":"Gscho\u00dfmann J","key":"bibr4-096721099400200608"},{"key":"bibr5-096721099400200608","first-page":"1139","volume":"9","author":"Czer LS","year":"1987","journal-title":"Treatment of severe platelet dysfunction and hemorrhage after cardiopulmonary bypass: Reduction in blood product usage with desmopressin"},{"key":"bibr6-096721099400200608","first-page":"1402","volume":"314","author":"Salzman EW","year":"1986","journal-title":"Treatment with desmopressin acetate to reduce blood loss after cardiac surgery"},{"key":"bibr7-096721099400200608","first-page":"40","volume":"44","author":"Teoh KH","year":"1987","journal-title":"Blood conservation with membrane oxygenators and dipyridamole"},{"key":"bibr8-096721099400200608","first-page":"926","volume":"89","author":"Addonizio V","year":"1985","journal-title":"Iloprost (ZK 36374), a stable analogue of prostacyclin preserves platelets during stimulated extracorporeal circulation"},{"key":"bibr9-096721099400200608","first-page":"436","volume":"91","author":"Fish K","year":"1986","journal-title":"A prospective, randomised study of the effects of prostacyclin on platelets and blood loss during coronary bypass operations"},{"key":"bibr10-096721099400200608","first-page":"479","volume":"33","author":"Fritz H","year":"1983","journal-title":"Biochemistry and applications of aprotinin, the kallikrein inhibitor from bovine organs"},{"key":"bibr11-096721099400200608","first-page":"236","volume":"29","author":"Verstraete M","year":"1985","journal-title":"Clinical applications of inhibitors of fibrinolysis"},{"key":"bibr12-096721099400200608","first-page":"1","volume":"52","author":"Aoki N","year":"1978","journal-title":"Inhibition of platelet aggregation by protease inhibitors. Possible involvement of proteases in platelet aggregation"},{"key":"bibr13-096721099400200608","first-page":"364","volume":"97","author":"Bidstrup BP","year":"1989","journal-title":"Reduction in blood loss and blood use after cardiopulmonary bypass with high-dose aprotinin (Trasylol)"},{"key":"bibr14-096721099400200608","first-page":"79","volume":"3","author":"Dietrich W","year":"1989","journal-title":"High-dose aprotinin application reduces homologous blood requirement in cardiac surgery"}],"container-title":["Cardiovascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/096721099400200608","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/096721099400200608","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T22:54:54Z","timestamp":1740783294000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/096721099400200608"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,12]]},"references-count":14,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1994,12]]}},"alternative-id":["10.1177\/096721099400200608"],"URL":"https:\/\/doi.org\/10.1177\/096721099400200608","relation":{},"ISSN":["0967-2109"],"issn-type":[{"type":"print","value":"0967-2109"}],"subject":[],"published":{"date-parts":[[1994,12]]}}}