{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T05:46:00Z","timestamp":1740807960595,"version":"3.38.0"},"reference-count":44,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1995,8,1]],"date-time":"1995-08-01T00:00:00Z","timestamp":807235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovascular Surgery"],"published-print":{"date-parts":[[1995,8]]},"abstract":"<jats:p> The purpose of this study was to evaluate the impact of an aortopulmonary shunt on exercise capacity in long-term survivors after total repair of tetralogy of Fallot (17.6(2.0) years' follow-up). Submaximal exercise tests, pulmonary function tests, lung diffusion tests for carbon monoxide, two-dimensional and Doppler echocardiography were performed in 12 patients with an aortopulmonary shunt (group A) and in 21 patients (group B) without a shunt before repair. There were no significant differences in two-dimensional and Doppler echocardiographic findings nor in pulmonary function. Group A showed a significantly lower diffusion capacity of the lung for carbon monoxide at rest (66.2(13.0)% versus 84.1 (9.5)%; P&lt;0.01) and at the anaerobic threshold (71.8(11.0)% versus 87.2(9.8)%; P&lt; 0.01) as well as a significantly reduced physical working capacity at ventilatory anaerobic threshold (1.6) (0.32) W\/kg versus 2.41 (0.43) W\/kg; P&lt;0.01). A negative correlation was observed between the duration of palliative shunts and diffusion capacity of the lung for carbon monoxide at rest at ventilatory anaerobic threshold (r = \u22120.8635 and \u22120.9108 respectively). A shunt placed before definitive repair impairs the long-term working capacity, probably by diminishing the diffusion capacity of the lung for carbon monoxide, especially if the shunt is in place for more than 20 months. <\/jats:p>","DOI":"10.1177\/096721099500300403","type":"journal-article","created":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T16:25:00Z","timestamp":1727108700000},"page":"369-374","source":"Crossref","is-referenced-by-count":0,"title":["Does an Aortopulmonary Shunt before Repair of Tetralogy of Fallot Limit Exercise Tolerance in Long-Term Survivors?"],"prefix":"10.1177","volume":"3","author":[{"given":"R.","family":"Leyh","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery, University of L\u00fcbeck, L\u00fcbeck, 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