{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:24:19Z","timestamp":1762161859428,"version":"3.38.0"},"reference-count":22,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1996,2,1]],"date-time":"1996-02-01T00:00:00Z","timestamp":823132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovascular Surgery"],"published-print":{"date-parts":[[1996,2]]},"abstract":"<jats:p> Twenty-eight patients treated with thrombolytic therapy for acute deep venous thrombosis were monitored prospectively with non-invasive testing every 12\u201324 h during treatment to evaluate thrombus response and whether duration of therapy was appropriate. Some 75% (21 of 28) of patients demonstrated improvement with lytic therapy with 36% (10 of 28) demonstrating complete lysis; 95% of responders (20 of 21) initiated lysis within 24 h. Some 33% (7 of 21) of all responders and 64% (7 of 11) of those having partial lysis had treatment terminated during thombus resolution but before maximal lysis. Non-invasive testing indicated that thrombolytic therapy for acute deep venous thrombosis is frequently terminated before maximal lysis of the thrombus. Monitoring thrombus response with venous duplex imaging should be part of the treatment strategy of deep venous thrombosis if thrombolytic therapy is used. This approach should increase efficacy and potentially reduce complications of thrombolytic therapy for acute deep venous thrombosis. <\/jats:p>","DOI":"10.1177\/096721099600400120","type":"journal-article","created":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T08:14:24Z","timestamp":1727165664000},"page":"101-104","source":"Crossref","is-referenced-by-count":2,"title":["Thrombolytic Therapy for Acute Deep Venous Thrombosis: How Much is Enough?"],"prefix":"10.1177","volume":"4","author":[{"given":"A. J.","family":"Comerota","sequence":"first","affiliation":[{"name":"Temple University Hospital, Section of Vascular Surgery, Department of Surgery, Broad & Ontario Streets. Philadelphia, PA 19140, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. L.","family":"Katz","sequence":"additional","affiliation":[{"name":"Temple University Hospital, Section of Vascular Surgery, Department of Surgery, Broad & Ontario Streets. Philadelphia, PA 19140, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. V.","family":"White","sequence":"additional","affiliation":[{"name":"Temple University Hospital, Section of Vascular Surgery, Department of Surgery, Broad & Ontario Streets. Philadelphia, PA 19140, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1996,2,1]]},"reference":[{"key":"bibr1-096721099600400120","first-page":"1013","volume":"89","author":"Marder VJ","year":"1977","journal-title":"J Lab Clin Med"},{"doi-asserted-by":"publisher","key":"bibr2-096721099600400120","DOI":"10.1111\/j.0954-6820.1978.tb14908.x"},{"key":"bibr3-096721099600400120","first-page":"973","volume":"74","author":"Tsapogas MJ","year":"1973","journal-title":"Surgery"},{"key":"bibr4-096721099600400120","first-page":"810","volume":"1","author":"Kakkar VV","year":"1969","journal-title":"Br Med J"},{"doi-asserted-by":"publisher","key":"bibr5-096721099600400120","DOI":"10.1002\/bjs.1800661203"},{"doi-asserted-by":"publisher","key":"bibr6-096721099600400120","DOI":"10.1111\/j.0954-6820.1982.tb01904.x"},{"unstructured":"Jeffrey P, Immelman E, Amoore J. Treatment of deep vein thrombosis with heparin or streptokinase: long-term venous function assessment. London, proceedings of the Second International Vascular Symposium 1986; Abstract No. S20. 3.","key":"bibr7-096721099600400120"},{"doi-asserted-by":"publisher","key":"bibr8-096721099600400120","DOI":"10.1136\/bmj.1.5956.479"},{"doi-asserted-by":"publisher","key":"bibr9-096721099600400120","DOI":"10.1016\/0741-5214(84)90019-3"},{"key":"bibr10-096721099600400120","first-page":"573","volume":"91","author":"Comerota AJ","year":"1982","journal-title":"Surgery"},{"key":"bibr11-096721099600400120","first-page":"32","volume":"1","author":"Comerota AJ","year":"1988","journal-title":"Semin Vasc Surg"},{"doi-asserted-by":"publisher","key":"bibr12-096721099600400120","DOI":"10.1016\/0741-5214(90)90328-8"},{"key":"bibr13-096721099600400120","first-page":"1336","volume":"110","author":"Rabinov K","year":"1972","journal-title":"Arch Surg"},{"doi-asserted-by":"publisher","key":"bibr14-096721099600400120","DOI":"10.1016\/0741-5214(89)90223-1"},{"doi-asserted-by":"publisher","key":"bibr15-096721099600400120","DOI":"10.1016\/0741-5214(93)90069-X"},{"doi-asserted-by":"publisher","key":"bibr16-096721099600400120","DOI":"10.1001\/archsurg.1979.01370350106012"},{"doi-asserted-by":"publisher","key":"bibr17-096721099600400120","DOI":"10.1016\/0741-5214(92)90228-Z"},{"doi-asserted-by":"publisher","key":"bibr18-096721099600400120","DOI":"10.1056\/NEJM197912063012305"},{"doi-asserted-by":"publisher","key":"bibr19-096721099600400120","DOI":"10.1016\/0741-5214(88)90377-1"},{"doi-asserted-by":"publisher","key":"bibr20-096721099600400120","DOI":"10.1001\/jama.1990.03440170035032"},{"doi-asserted-by":"publisher","key":"bibr21-096721099600400120","DOI":"10.1016\/0002-9610(89)90361-9"},{"doi-asserted-by":"publisher","key":"bibr22-096721099600400120","DOI":"10.1016\/0741-5214(94)90012-4"}],"container-title":["Cardiovascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/096721099600400120","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/096721099600400120","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T16:03:28Z","timestamp":1740931408000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/096721099600400120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,2]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1996,2]]}},"alternative-id":["10.1177\/096721099600400120"],"URL":"https:\/\/doi.org\/10.1177\/096721099600400120","relation":{},"ISSN":["0967-2109"],"issn-type":[{"type":"print","value":"0967-2109"}],"subject":[],"published":{"date-parts":[[1996,2]]}}}