{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T22:03:44Z","timestamp":1767650624060,"version":"build-2065373602"},"reference-count":33,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1998,4,1]],"date-time":"1998-04-01T00:00:00Z","timestamp":891388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovascular Surgery"],"published-print":{"date-parts":[[1998,4]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> The objective of this study was to analyse the impact of acute surgery for native aortic valve endocarditis and its influence on the long-Term prognosis after surgery. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> A total of 161 patients underwent aortic valve replacement for native active aortic valve endocarditis (NAAVE) during a 29-year period, from 1967 to 1995 (age range: 10 to 72 years; mean 48 \u00b1 12). The main indication for surgery was progressive congestive heart failure (76%). Other indications were untreatable sepsis (27%), peripheral or central emboli (12%) and, from 1978, echocardiographic evidence of friable, pedunculated vegetations (3%). Streptococcal and staphylococcal infections predominated. Concomitant procedures were performed in 27% of the patients, including mitral and tricuspid valve surgery and coronary bypass procedures. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> Operative mortality was 8% in the majority of cases caused by heart failure or multiorgan failure. Multivariate logistic regression analysis identified NYHA class IV to be an independent predictor for postoperative death. Long-term survival for discharged patients was 75% at 10 years and 58% at 15 years, with a mortality rate of 3.6%\/patient\/year. Cox regression analysis identified the year of operation, trivalvular endocarditis and staphylococcal infection as independent predictors of survival. At 10 and 15 years after aortic valve replacement, 91% and 84% of the patients, respectively, were free of recurrent endocarditis. The presence of an abscess cavity at first operation was found to be predictive of recurrent endocarditis. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p> Valve replacement for NAAVE offers a good chance for a cure and satisfactory long-term survival. Improvements in pre- and per-operative management of the very ill patient, and the use of allograft valves are likely to further improve long-term results. Finally, the presence of staphylococcal endocarditis requires long-term postoperative antibiotic therapy. <\/jats:p><\/jats:sec>","DOI":"10.1177\/096721099800600204","type":"journal-article","created":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T19:45:01Z","timestamp":1727120701000},"page":"126-132","source":"Crossref","is-referenced-by-count":6,"title":["Long-Term Survival after Aortic Valve Replacement for Native Active Infective Endocarditis"],"prefix":"10.1177","volume":"6","author":[{"given":"G.","family":"Pompilio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Brockmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Bruneau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Buche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Amrani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Louagie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Eucher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Rubay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Jamart","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Clinics of the Catholic University of Louvain (UCL), Brussels and Mont-Godinne Hospital, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Dion","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.-C.","family":"Schoevaerdts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1998,4,1]]},"reference":[{"key":"bibr1-096721099800600204","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.58.4.598"},{"key":"bibr2-096721099800600204","first-page":"124","volume-title":"Current Clinical Topics in Infectious Diseases","author":"Karchmer A.","year":"1980"},{"key":"bibr3-096721099800600204","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-96-5-650"},{"key":"bibr4-096721099800600204","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(10)60097-5"},{"key":"bibr5-096721099800600204","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.69.2.223"},{"key":"bibr6-096721099800600204","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(93)90885-G"},{"key":"bibr7-096721099800600204","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5273(89)90040-5"},{"issue":"2","key":"bibr8-096721099800600204","first-page":"II-175","volume":"90","author":"Aranki S. 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