{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T05:53:44Z","timestamp":1740894824991,"version":"3.38.0"},"reference-count":25,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1998,4,1]],"date-time":"1998-04-01T00:00:00Z","timestamp":891388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovascular Surgery"],"published-print":{"date-parts":[[1998,4]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> Splanchnic artery occlusion shock is caused by increased capillary permeability and cellular injury precipitated by oxygen derived free radicals following ischemia and reperfusion of splanchnic organs. The purpose of this study was to assess the role of several well-known oxygen-derived free radical scavengers in ameliorating or preventing this syndrome. <\/jats:p><\/jats:sec><jats:sec><jats:title>Study design:<\/jats:title><jats:p> Anesthetized rats were subjected to periods of occlusion of the visceral arteries and reperfusion. Tocopherol, taurine, selenium or a \u2018cocktail\u2019 of these three agents was injected subcutaneously for 4 consecutive days prior to operation. Mean arterial blood pressure was measured throughout the experimental period. Fluorometry and technetium-99m pyrophosphate counting of the visceral organs were performed as well as a histologic grading system for intestinal viability. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> Final mean arterial blood pressure associated with the \u2018cocktail\u2019 and selenium groups was 79.1 \u00b1 27.4 mmHg and 83.6 \u00b1 17.8 mmHg, respectively. These values were significantly higher than the control group, 40.8 \u00b1 11.4 mmHg ( P &lt; 0.05). Similar patterns of the benefit of selenium in contrast with the other groups were obtained with fluorescein perfusion, radioisotopic activity and histologic analysis. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> Pretreatment with selenium of splanchnic ischemia and reperfusion in the rat improves mean arterial blood pressure and microcirculatory visceral perfusion. Further analysis of the precise protective mechanism of selenium for reperfusion injury will enable visceral organs to withstand the consequences of increased capillary leakage and oxidant injury. <\/jats:p><\/jats:sec>","DOI":"10.1177\/096721099800600212","type":"journal-article","created":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T19:45:01Z","timestamp":1727120701000},"page":"178-187","source":"Crossref","is-referenced-by-count":0,"title":["Effect of \u03b1-Tocopherol, Taurine and Selenium on the Attenuation of Ischemia\/Reperfusion Injury of Splanchnic Organs"],"prefix":"10.1177","volume":"6","author":[{"given":"W. B.","family":"Yoshida","sequence":"first","affiliation":[{"name":"Department of Surgery of Englewood Hospital and Medical Center, Englewood, New Jersey, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Alasio","sequence":"additional","affiliation":[{"name":"Department of Surgery of Englewood Hospital and Medical Center, Englewood, New Jersey, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Mazziotta","sequence":"additional","affiliation":[{"name":"Department of Surgery of Englewood Hospital and Medical Center, Englewood, New Jersey, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Surgery of Englewood Hospital and Medical Center, Englewood, New Jersey, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Kashani","sequence":"additional","affiliation":[{"name":"Department of Pathology of Englewood Hospital and Medical Center, Englewood, New Jersey, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Surgery of Englewood Hospital and Medical Center, Englewood, New Jersey, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Dardik","sequence":"additional","affiliation":[{"name":"Department of Surgery of Englewood Hospital and Medical Center, Englewood, New Jersey, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1998,4,1]]},"reference":[{"key":"bibr1-096721099800600212","first-page":"523","volume-title":"Vascular Surgery A Comprehensive Review","author":"Bergan J. 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