{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:44:05Z","timestamp":1777855445206,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2014,2,11]],"date-time":"2014-02-11T00:00:00Z","timestamp":1392076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Med Biogr"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:p>The physician Charles-\u00c9douard Brown-S\u00e9quard was a neurologist of considerable importance. In 1846 his thesis \u2018Researches and Experiments on the Physiology of the Spinal Cord\u2019 brought out knowledge about the sensory pathways which remains until today. The Emperor, Dom Pedro II was the second and last Emperor of Brazil, reigning for 49 years and remembered for defending the nation\u2019s integrity, the end of slavery, support for education and culture, diplomacy and relations with international personalities. He married Dona Teresa Cristina of Bourbon-Two Sicilies (1822\u20131889) by proxy in 1843, the fourth and last Empress consort of Brazil. This paper reports the exchange of letters between these personalities of the XIX century. Although they lived far from each other and worked in areas so different, they discussed the health of the Empress in letters. Dom Pedro II made contact with Brown-S\u00e9quard hoping that \u2018\u2009\u2026\u2009your knowledge shall help heal my wife of nervous disease\u2009\u2026\u2009.\u2009\u2019\u2009According to Dom Pedro the Empress suffered \u2018\u2009\u2026\u2009for a long time with more or less long interruptions of horrible neuralgic pains in the legs, head and the scalp. Two points on the dorsal spine feel the effects more or less with pressure applied\u2009\u2026\u2009.\u2009\u2019\u2009In addition to describing and documenting the exchange of letters, this paper raises the possibility that the Empress suffered from the fibromyalgia syndrome.<\/jats:p>","DOI":"10.1177\/0967772013506682","type":"journal-article","created":{"date-parts":[[2014,2,11]],"date-time":"2014-02-11T20:22:59Z","timestamp":1392150179000},"page":"45-50","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["The physician, the Emperor and the fibromyalgia: Charles-\u00c9douard Brown-S\u00e9quard (1817\u20131894) and Dom Pedro II (1825\u20131891) of Brazil"],"prefix":"10.1177","volume":"24","author":[{"given":"Patricia Shu","family":"Kurizky","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Cristina Vanderley","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Licia Maria Henrique","family":"da Mota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo Rios","family":"Diniz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leopoldo Luiz dos Santos","family":"Neto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,2,11]]},"reference":[{"key":"bibr1-0967772013506682","doi-asserted-by":"publisher","DOI":"10.1227\/01.neu.0000318182.87664.1f"},{"key":"bibr2-0967772013506682","volume-title":"A educa\u00e7\u00e3o de D Pedro II, Imperador do Brasil","author":"Quintanilha MMS","year":"2004"},{"key":"bibr3-0967772013506682","unstructured":"Aminoff MJ. Brown-S\u00e9quard. A visionary of science, New York: Raven Press, 1993, pp. 92\u201392."},{"key":"bibr4-0967772013506682","volume-title":"Memoir of Charles Edouard Brown-S\u00e9quard (1817\u20131894)","author":"Bowditch HP","year":"1897"},{"key":"bibr5-0967772013506682","first-page":"237","volume":"24","author":"Anger J","year":"2009","journal-title":"Revista Brasileira de Cirurgia Pl\u00e1stica"},{"key":"bibr6-0967772013506682","volume-title":"Toda a hist\u00f3ria","author":"Arruda JJA","year":"1995","edition":"1"},{"key":"bibr7-0967772013506682","first-page":"161","volume":"3","author":"Falco Genovez PF","year":"1998","journal-title":"Tempo"},{"key":"bibr8-0967772013506682","volume-title":"Cole\u00e7\u00e3o D. Thereza Christina Maria","author":"Biblioteca Nacional (Brasil)","year":"1987"},{"key":"bibr9-0967772013506682","volume-title":"Tempo de vida, doen\u00e7a e morte na Casa de Bragan\u00e7a (ramo do Brasil)","author":"Farina DC","year":"1979","edition":"1"},{"key":"bibr10-0967772013506682","unstructured":"Zerbini ECG. A imperatriz invis\u00edvel. \u2018\n                      Revista de Hist\u00f3ria da Biblioteca Nacional\n                      \u2019 [serial online] (2007, accessed 17 February 2007). Available at: http:\/\/www.revistadehistoria.com.br\/secao\/retrato\/a-imperatriz-invisivel."},{"key":"bibr11-0967772013506682","first-page":"54","volume":"2","author":"Santos NP","year":"2004","journal-title":"Revista da Sociedade Brasileira da Hist\u00f3ria da Ci\u00eancia"},{"key":"bibr12-0967772013506682","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-282X2007000700034"},{"key":"bibr13-0967772013506682","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-282X2008000500036"},{"key":"bibr14-0967772013506682","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-282X2001000200032"},{"key":"bibr15-0967772013506682","unstructured":"Julien P. L\u0388mpereur du Br\u00e9sil et ses m\u00e9dicins. Revue D\u2019Histoire de la Pharmacie, d\u2019apr\u00e8s: Ara\u00fajo S. Grave doen\u00e7a do Imperador do Brasil em Mil\u00e3o, em 1888. M\u00e9dicos italianos que o trataram. Trabalho apresentado ao XXI Congresso Internacional de Hist\u00f3ria de Medicina, r\u00e9unido em Siena (It\u00e1lia), de 22 a 28 de Setembro de 1968, Rio de Janeiro, l\u2019auteur, 1968, in 8\u00b0, 12p., 1 pl.h-t; r\u00e9sum\u00e9 en fr et ital."},{"key":"bibr16-0967772013506682","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-282X2007000700035"},{"key":"bibr17-0967772013506682","volume-title":"ALS to Brown-S\u00e9quard MS-BROWC\/981\/21","author":"Royal College of Physicians","year":"1876"},{"key":"bibr18-0967772013506682","volume-title":"Minist\u00e9rio da Cultura","author":"Museu Imperial de Petr\u00f3polis (Brasil)","year":"1876"},{"key":"bibr19-0967772013506682","volume-title":"ALS to Brown-S\u00e9quard MS-BROWC\/981\/22","author":"Royal College of Physicians","year":"1876"},{"key":"bibr20-0967772013506682","doi-asserted-by":"publisher","DOI":"10.1016\/j.disamonth.2011.02.001"},{"key":"bibr21-0967772013506682","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2009.09.006"},{"key":"bibr22-0967772013506682","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2010.07.004"}],"container-title":["Journal of Medical Biography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0967772013506682","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0967772013506682","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0967772013506682","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T23:24:57Z","timestamp":1777505097000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0967772013506682"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,11]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.1177\/0967772013506682"],"URL":"https:\/\/doi.org\/10.1177\/0967772013506682","relation":{},"ISSN":["0967-7720","1758-1087"],"issn-type":[{"value":"0967-7720","type":"print"},{"value":"1758-1087","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,11]]}}}