{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:43:23Z","timestamp":1777855403817,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Med Biogr"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:p>Eug\u00e8ne Hertoghe (1860\u20131928), a Belgian internist and former vice-president of the Royal Academy of Medicine of Belgium, made significant contributions to the understanding and treatment of chronic hypothyroidism. He provided a detailed clinical description of the condition, emphasizing its multisystemic manifestations and hereditary aspects. Hertoghe also documented the therapeutic use of thyroid extract, reporting its effectiveness in alleviating symptoms of hypothyroidism. Among his contributions, he described the \u201cHertoghe sign,\u201d a rare clinical feature characterized by the loss of the outer third of the eyebrows, commonly associated with myxoedema, as well as with cases of toxic poisoning, infections, and atopic dermatitis.<\/jats:p>","DOI":"10.1177\/09677720241307877","type":"journal-article","created":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T04:33:37Z","timestamp":1736224417000},"page":"67-72","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Eugene Hertoghe (1860\u20131928): Pioneer in endocrinology and the treatment of hypothyroidism"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8705-0232","authenticated-orcid":false,"given":"Halil","family":"Tekiner","sequence":"first","affiliation":[{"name":"Erciyes University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eileen S.","family":"Yale","sequence":"additional","affiliation":[{"name":"Department of Medicine, Nova Southeastern University Medical School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6159-467X","authenticated-orcid":false,"given":"Steven H.","family":"Yale","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Central Florida College of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,1,7]]},"reference":[{"key":"e_1_3_3_2_2","volume-title":"Stedman\u2019s Medical Eponyms","author":"Bartolucci S","year":"2005","unstructured":"Bartolucci S, Forbis P. Stedman\u2019s Medical Eponyms. 2nd ed. Baltimore: Lippincott Williams & Wilkins, 2005.","edition":"2"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03401282"},{"key":"e_1_3_3_4_2","first-page":"474","article-title":"\u00c9loge du Docteur Eug\u00e8ne Hertoghe [Tribute to Doctor Eug\u00e8ne Hertoghe]","volume":"15","author":"D\u2019Hollander F","year":"1935","unstructured":"D\u2019Hollander F. \u00c9loge du Docteur Eug\u00e8ne Hertoghe [Tribute to Doctor Eug\u00e8ne Hertoghe]. Bull Acad M\u00e9d Belg 1935; 15: 474\u2013 481.","journal-title":"Bull Acad M\u00e9d Belg"},{"key":"e_1_3_3_5_2","volume-title":"Chronique illustr\u00e9e de la Famille Hertoghe d\u2019Anvers [Illustrated chronicle of the Hertoghe Family of Antwerp]","author":"Hertoghe H","year":"1966","unstructured":"Hertoghe H, Hertoghe L. Chronique illustr\u00e9e de la Famille Hertoghe d\u2019Anvers [Illustrated chronicle of the Hertoghe Family of Antwerp]. Antwerp: [n.a.], 1966."},{"key":"e_1_3_3_6_2","first-page":"2","article-title":"Notice sur la vie et les travaux de M. Hertoghe [Notice on the life and work of M. Hertoghe]","volume":"5","author":"van Ermengem E","year":"1928","unstructured":"van Ermengem E. Notice sur la vie et les travaux de M. Hertoghe [Notice on the life and work of M. Hertoghe]. Bulletin De L'academie Royale De Medecine De Belgique 1928; 5: 2\u2013 7.","journal-title":"Bulletin De L'academie Royale De Medecine De Belgique"},{"key":"e_1_3_3_7_2","volume-title":"Le docteur Eug\u00e8ne Hertoghe (1860-1928): in memoriam [Doctor Eug\u00e8ne Hertoghe (1860-1928): in memoriam]","author":"Mets AD","year":"1929","unstructured":"Mets AD. Le docteur Eug\u00e8ne Hertoghe (1860-1928): in memoriam [Doctor Eug\u00e8ne Hertoghe (1860-1928): in memoriam]. Antwerp: Boursel, 1929."},{"key":"e_1_3_3_8_2","first-page":"188","article-title":"Complimentary dinner given by Dr. William Seaman Bainbridge","volume":"27","author":"[No author]","year":"1914","unstructured":"[No author]. Complimentary dinner given by Dr. William Seaman Bainbridge. International Journal of Surgery 1914; 27: 188\u2013 190.","journal-title":"International Journal of Surgery"},{"key":"e_1_3_3_9_2","unstructured":"[No author]. Eug\u00e8ne Ludovic Christian Hertoghe 1860\u20131928. My Heritage. https:\/\/www.myheritage.com.tr\/names\/eug%C3%A8ne_hertoghe (accessed 11 October 2024)."},{"key":"e_1_3_3_10_2","unstructured":"Hertoghe T. Dr. Hertoghe Clinic. https:\/\/www.hertoghe.eu\/en\/ (accessed 21 October 2024)."},{"key":"e_1_3_3_11_2","first-page":"5","volume-title":"Manifestation Eug\u00e8ne Hertoghe","author":"Ide M","year":"1938","unstructured":"Ide M. Discours de Monsieur le Professeur Ide [Speech by Professor Ide]. In: Manifestation Eug\u00e8ne Hertoghe. Louvain: Impr. Joseph Meulemans, 1938, pp. 5\u2013 7."},{"key":"e_1_3_3_12_2","first-page":"897","article-title":"De l\u2019influence des produits thyro\u00efdiens sur la croissance [The influence of thyroid products on growth]","volume":"9","author":"Hertoghe E","year":"1895","unstructured":"Hertoghe E. De l\u2019influence des produits thyro\u00efdiens sur la croissance [The influence of thyroid products on growth]. Bulletin de l'Acad\u00e9mie Royale de M\u00e9decine de Belgique 1895; 9: 897\u2013 935.","journal-title":"Bulletin de l'Acad\u00e9mie Royale de M\u00e9decine de Belgique"},{"key":"e_1_3_3_13_2","volume-title":"Bibliographies du Dr. Eug\u00e8ne Hertoghe [Bibliographies of Dr. Eugene Hertoghe]","author":"Hertoghe E","unstructured":"Hertoghe E. Bibliographies du Dr. Eug\u00e8ne Hertoghe [Bibliographies of Dr. Eugene Hertoghe]. Brussels: Doctor Eug\u00e8ne Hertoghe Research Foundation Archives, [undated]."},{"key":"e_1_3_3_14_2","volume-title":"Le Probl\u00e8me du Cancer [The Problem of Cancer]","author":"Bainbridge WS","year":"1922","unstructured":"Bainbridge WS. Le Probl\u00e8me du Cancer [The Problem of Cancer]. trans: Hertoghe E. Paris: Doin, 1922."},{"key":"e_1_3_3_15_2","volume-title":"De l\u2019hypothyro\u00efdie b\u00e9nigne chronique ou myxoed\u00e8me fruste [On chronic benign hypothyroidism or mild myxoedema]","author":"Hertoghe E","year":"1899","unstructured":"Hertoghe E. De l\u2019hypothyro\u00efdie b\u00e9nigne chronique ou myxoed\u00e8me fruste [On chronic benign hypothyroidism or mild myxoedema]. Bruxelles: Hayez, 1899."},{"key":"e_1_3_3_16_2","volume-title":"Nouvelles recherches sur les insuffisances thyro\u00efdiennes: L\u2019incontinence d\u2019urine nocturne chez les enfants et les adolescents [New research on thyroid insufficiencies: Nocturnal urinary incontinence in children and adolescents]","author":"Hertoghe E","year":"1907","unstructured":"Hertoghe E. Nouvelles recherches sur les insuffisances thyro\u00efdiennes: L\u2019incontinence d\u2019urine nocturne chez les enfants et les adolescents [New research on thyroid insufficiencies: Nocturnal urinary incontinence in children and adolescents]. Bruxelles: Hayez, 1907."},{"key":"e_1_3_3_17_2","volume-title":"Le coma myx\u0153d\u00e9mateux [Myxoedema Coma]","author":"Hertoghe E","year":"1911","unstructured":"Hertoghe E. Le coma myx\u0153d\u00e9mateux [Myxoedema Coma]. Anvers: J.E. Buschmann, 1911."},{"key":"e_1_3_3_18_2","first-page":"735","article-title":"Minor signs of thyroid insufficiency","volume":"32","author":"Aikens WHB","year":"1907","unstructured":"Aikens WHB, Hamilton HJ, Copp CJ, et al. Minor signs of thyroid insufficiency. Can Pract 1907; 32: 735\u2013 739.","journal-title":"Can Pract"},{"key":"e_1_3_3_19_2","first-page":"430","article-title":"Syndrome hypophyso-g\u00e9nital d\u2019origine syphilitique (pr\u00e9sentation de malade) [Hypophyseal-gonadal syndrome of syphilitic origin (patient presentation)]","volume":"31","author":"Carnot P","year":"1912","unstructured":"Carnot P, Dumont J. Syndrome hypophyso-g\u00e9nital d\u2019origine syphilitique (pr\u00e9sentation de malade) [Hypophyseal-gonadal syndrome of syphilitic origin (patient presentation)]. Bull et M\u00e9m Soc M\u00e9d H\u00f4p Paris 1912; 31: 430\u2013 435.","journal-title":"Bull et M\u00e9m Soc M\u00e9d H\u00f4p Paris"},{"key":"e_1_3_3_20_2","first-page":"193","article-title":"Contribution \u00e0 l\u2019\u00e9tude de l\u2019insuffisance thyro\u00efdienne: huit cas de myxoed\u00e8me incomplet [Contribution to the study of thyroid insufficiency: eight cases of incomplete myxoedema]","volume":"9","author":"L\u00e9vi L","year":"1907","unstructured":"L\u00e9vi L, de Rothschild H. Contribution \u00e0 l\u2019\u00e9tude de l\u2019insuffisance thyro\u00efdienne: huit cas de myxoed\u00e8me incomplet [Contribution to the study of thyroid insufficiency: eight cases of incomplete myxoedema]. Rev Hyg M\u00e9d Infant 1907; 9: 193\u2013 249.","journal-title":"Rev Hyg M\u00e9d Infant"},{"key":"e_1_3_3_21_2","volume-title":"Diagnosis and Treatment of Thyroid Diseases","author":"Pittman JA","year":"1963","unstructured":"Pittman JA. Diagnosis and Treatment of Thyroid Diseases. Philadelphia: F.A. Davis, 1963."},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-49872-6_2"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1258\/j.jmb.2007.06-13"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2020.06.088"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcw046"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-02671-7_5"},{"key":"e_1_3_3_27_2","first-page":"50","article-title":"Evaluation and relevance of atopic basic and minor features in patients with atopic dermatitis and in the general population","volume":"69","author":"Diepgen TL","year":"1989","unstructured":"Diepgen TL, Fartasch M, Hornstein OP. Evaluation and relevance of atopic basic and minor features in patients with atopic dermatitis and in the general population. Acta Dermato-Venereologica 1989; 69: 50\u2013 54.","journal-title":"Acta Dermato-Venereologica"}],"container-title":["Journal of Medical Biography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09677720241307877","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09677720241307877","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09677720241307877","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T23:23:47Z","timestamp":1777505027000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09677720241307877"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,7]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1177\/09677720241307877"],"URL":"https:\/\/doi.org\/10.1177\/09677720241307877","relation":{},"ISSN":["0967-7720","1758-1087"],"issn-type":[{"value":"0967-7720","type":"print"},{"value":"1758-1087","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,7]]}}}