{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T10:48:59Z","timestamp":1792838939275,"version":"4.5.0"},"reference-count":22,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2003,9,1]],"date-time":"2003-09-01T00:00:00Z","timestamp":1062374400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Screen"],"published-print":{"date-parts":[[2003,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To evaluate a community-based screening programme for detecting neonata\/liver disease by the quantitation of conjugated bilirubin in blood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting and Methods:<\/jats:title>\n                    <jats:p>Prospective cohort\/observational study using spare plasma from routinely collected liquid neonatal screening specimens from babies born in Birmingham over a two-year period. Babies with a conjugated bilirubin above 18 umol\/l and comprising more than 20% of the total bilirubin were followed up. A total of 27,654 neonates were tested in the community, with a further 2425 samples from babies hospitalised at the time of the test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In the community-based series, 84.7% of the specimens received were analysed, the remainder being unusable mainly because of gross hoemolysis (8.6%) or insufficient sample (5.8%). In 107 neonates the results were above the cut-off limits (0.46% of the number analysed). Of these, 12 had persistently abnormal results, 11 of whom hod confirmed liver disease. The liver diseases detected included neonatal hepatitis (n=6), extra-hepatic biliary atresia (n=2), hypopituitarism In= 1), a-1antitrypsin deficiency (n=1) and Alagille syndrome (n= 1). The sensitivity and specificity of the test for babies in the community were 100% and 99.6%, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Conjugated bilirubin in plasma measured at 6\u201310 days is a reliable marker for neonatal liver disease, and a population screening programme based on this method has the potential to improve the survival and quality of life of infants born with liver disease. However, testing as part of the neonatal screening programme will prove practical only iF the method can be adapted to use dried blood spots<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/096914130301000303","type":"journal-article","created":{"date-parts":[[2017,1,12]],"date-time":"2017-01-12T20:28:07Z","timestamp":1484252887000},"page":"112-116","source":"Crossref","is-referenced-by-count":55,"title":["Population Screening for Neonatal Liver Disease: Potential for a Community-Based Programme"],"prefix":"10.1177","volume":"10","author":[{"given":"J E","family":"Powell","sequence":"first","affiliation":[{"name":"J E Powell, Lecturer in Public Health and Epidemiology, Department of Public Health and Epidemiology, University of Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Keffler","sequence":"additional","affiliation":[{"name":"S Keffler, formerly Principal Biochemist, Department of Clinical Chemistry, Birmingham Children's Hospital NHS Trust, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D A","family":"Kelly","sequence":"additional","affiliation":[{"name":"D A Kelly, Professor in Paediatric Hepatology, The Liver Unit, Birmingham Children's Hospital NHS Trust, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Green","sequence":"additional","affiliation":[{"name":"A Green, Reader in Paediatric Biochemistry, University of Birmingham, and Consultant Paediatric Biochemist, Department of Clinical Chemistry, Birmingham Children's Hospital NHS Trust, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2003,9,1]]},"reference":[{"key":"bibr1-096914130301000303","doi-asserted-by":"publisher","DOI":"10.1136\/adc.60.6.512"},{"key":"bibr2-096914130301000303","first-page":"949","volume":"60","author":"Mathew PM","year":"1985","journal-title":"Arch Dis Child"},{"key":"bibr3-096914130301000303","first-page":"113","volume":"20","author":"Knisely AS.","year":"1990","journal-title":"Ann Clin Lab Sci"},{"key":"bibr4-096914130301000303","doi-asserted-by":"publisher","DOI":"10.1007\/BF01797923"},{"key":"bibr5-096914130301000303","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.310.6988.1172"},{"key":"bibr6-096914130301000303","doi-asserted-by":"publisher","DOI":"10.1136\/adc.72.1.90"},{"key":"bibr7-096914130301000303","doi-asserted-by":"publisher","DOI":"10.1007\/BF00176587"},{"key":"bibr8-096914130301000303","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(90)90390-U"},{"key":"bibr9-096914130301000303","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)03492-3"},{"key":"bibr10-096914130301000303","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200103000-00006"},{"key":"bibr11-096914130301000303","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)92685-9"},{"key":"bibr12-096914130301000303","doi-asserted-by":"publisher","DOI":"10.1136\/adc.69.5.545"},{"key":"bibr13-096914130301000303","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.303.6810.1105"},{"key":"bibr14-096914130301000303","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91814-3"},{"key":"bibr15-096914130301000303","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1999.tb00192.x"},{"key":"bibr16-096914130301000303","volume-title":"Early identification of liver disease in infants","author":"Jaundice Protocol for Community Healthcare Professionals","year":"2002"},{"key":"bibr17-096914130301000303","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.319.7208.471"},{"key":"bibr18-096914130301000303","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199809000-00007"},{"key":"bibr19-096914130301000303","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/32.3.470"},{"key":"bibr20-096914130301000303","doi-asserted-by":"publisher","DOI":"10.3310\/hta1070"},{"key":"bibr21-096914130301000303","unstructured":"Wilson JMG, Jungner G. 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