{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:07:16Z","timestamp":1777928836917,"version":"3.51.4"},"reference-count":6,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2013,11,25]],"date-time":"2013-11-25T00:00:00Z","timestamp":1385337600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Med Screen"],"published-print":{"date-parts":[[2013,12]]},"abstract":"\n Aim<\/jats:title>\n There are limited published data on the performance of the percentage of haemoglobin A (Hb A) as a screening test for beta thalassaemia major in the newborn period. This paper aims to analyse data derived from a national newborn bloodspot screening programme for sickle cell disease on the performance of haemoglobin A (Hb A) as a screening test for beta thalassaemia major in the newborn period.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Newborn bloodspot sickle cell screening data from 2,288,008 babies were analysed. Data reported to the NHS Sickle Cell and Thalassaemia Screening Programme in England for the period 2005 to 2012 were also reviewed to identify any missed cases (4,599,849 babies).<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Within the cohort of 2,288,008 births, 170 babies were identified as screen positive for beta thalassaemia major using a cut-point of 1.5% HbA. There were 51 identified through look-back methods and 119 prospectively identified from 4 screening laboratories. Among 119 babies with prospective data, 7 were lost to follow up and 15 were false positive results. Using a cut-off value of 1.5% Hb A as a percentage of the total haemoglobin as a screening test for beta thalassaemia major in the newborn provides an estimated sensitivity of 99% (from the look back arm of the study) with a positive predictive value of 87% (from the prospective arm of the study). Excluding infants born before 32 weeks gestation, the positive predictive value rose to 95%.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n A haemoglobin A value of less than 1.5% is a reliable screening test for beta thalassaemia major in the newborn period.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/0969141313514217","type":"journal-article","created":{"date-parts":[[2013,11,25]],"date-time":"2013-11-25T22:09:09Z","timestamp":1385417349000},"page":"183-187","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Newborn bloodspot results: predictive value of screen positive test for thalassaemia major"],"prefix":"10.1177","volume":"20","author":[{"given":"Allison","family":"Streetly","sequence":"first","affiliation":[{"name":"NHS Sickle Cell and Thalassaemia Screening Programme, King\u2019s College School of Medicine, 6th Floor, Capital House, 42 Weston Street, SE1 3QD, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radoslav","family":"Latinovic","sequence":"additional","affiliation":[{"name":"NHS Sickle Cell and Thalassaemia Screening Programme, King\u2019s College School of Medicine, 6th Floor, Capital House, 42 Weston Street, SE1 3QD, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan","family":"Henthorn","sequence":"additional","affiliation":[{"name":"NHS Sickle Cell and Thalassaemia Screening Programme, King\u2019s College School of Medicine, 6th Floor, Capital House, 42 Weston Street, SE1 3QD, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yvonne","family":"Daniel","sequence":"additional","affiliation":[{"name":"NHS Sickle Cell and Thalassaemia Screening Programme, King\u2019s College School of Medicine, 6th Floor, Capital House, 42 Weston Street, SE1 3QD, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Dormandy","sequence":"additional","affiliation":[{"name":"NHS Sickle Cell and Thalassaemia Screening Programme, King\u2019s College School of Medicine, 6th Floor, Capital House, 42 Weston Street, SE1 3QD, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phil","family":"Darbyshire","sequence":"additional","affiliation":[{"name":"Birmingham Children\u2019s Hospitals NHS Foundation Trust, Steel House Lane, B4 6NH, Birmingham"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debbie","family":"Mantio","sequence":"additional","affiliation":[{"name":"Haemoglobinopathy Laboratory, North West London, Hospitals NHS Trust, Park Royal, NW10 7NS, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Fraser","sequence":"additional","affiliation":[{"name":"Haemoglobinopathy Laboratory, North West London, Hospitals NHS Trust, Park Royal, NW10 7NS, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Farrar","sequence":"additional","affiliation":[{"name":"Leeds Teaching Hospitals NHS Trust, Beckett St, Leeds LS7 9TF"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Will","sequence":"additional","affiliation":[{"name":"Central Manchester and Manchester, Children\u2019s University Hospitals NHS Trust, Royal Manchester Children\u2019s Hospital, Oxford Road, M13 9WL, Manchester"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lesley","family":"Tetlow","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Central Manchester and Manchester Children\u2019s University Hospitals NHS Trust, 4th Floor, Paediatric Pathology, Oxford Road, M13 9WL, Manchester"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,11,25]]},"reference":[{"issue":"11","key":"bibr1-0969141313514217","first-page":"1","volume":"5","author":"Galanello ROR","year":"2010","journal-title":"Orpphanet Journal of rare diseases"},{"key":"bibr2-0969141313514217","unstructured":"NHS Sickle Cell and Thalassaemia Screening Programme.\n Handbook for Laboratories\n . 2012."},{"key":"bibr3-0969141313514217","unstructured":"Allaby M.\n Newborn screening for thalassaemia: a report for the NHS Sickle Cell and Thalassaemia Screening programme\n . 2011, Solutions for Public Health."},{"key":"bibr4-0969141313514217","unstructured":"NSC U.\n Minutes of UK National Screening Committee, 25 April 2012\n . 2012; Available from: http:\/\/www.screening.nhs.uk\/meetings."},{"key":"bibr5-0969141313514217","doi-asserted-by":"publisher","DOI":"10.1258\/jms.2011.011086"},{"key":"bibr6-0969141313514217","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.23173"}],"container-title":["Journal of Medical Screening"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0969141313514217","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0969141313514217","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0969141313514217","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:23:07Z","timestamp":1777677787000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0969141313514217"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,25]]},"references-count":6,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["10.1177\/0969141313514217"],"URL":"https:\/\/doi.org\/10.1177\/0969141313514217","relation":{},"ISSN":["0969-1413","1475-5793"],"issn-type":[{"value":"0969-1413","type":"print"},{"value":"1475-5793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,25]]}}}