{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:07:34Z","timestamp":1777928854684,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2014,1,31]],"date-time":"2014-01-31T00:00:00Z","timestamp":1391126400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Med Screen"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Cervical cancer screening by human papillomavirus (HPV) testing requires the use of additional triage and follow-up analyses. We evaluated women\u2019s compliance with and the performance of this strategy in a routine setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Five cervical service screening programmes in North-East Italy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eligible women aged 25-64 invited for a new screening episode underwent HPV testing for high risk types (hrHPV by Hybrid Capture 2) and cytology triage. Women with positive HPV and cytology results were referred for colposcopy; women with positive HPV but negative cytology results were referred to 1-year repeat hrHPV testing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 46,694 women screened by HPV testing up to December 2011, 3,211 (6.9%) tested hrHPV positive; 45% of these had a positive triage cytology. Those with negative cytology were invited for 1-yr repeat testing. Compliance with invitation was 61.6% at baseline and 85.3% at 1-yr repeat. Rate of persistent hrHPV positivity was 58% (830\/1,435). Colposcopy performed in women with a positive hrHPV test at 1-yr repeat accounted for 36% of all colposcopies performed within the screening programmes. Cumulatively, a histological high-grade lesion was detected in 276 women (5.9\u2030 detection rate), 234 at baseline (85%), and 42 (15%) at 1-yr repeat.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Compliance with hrHPV-based screening programmes was high both at baseline and at 1-yr repeat. Compared with the randomized trials, a higher proportion of triage cytology was read as positive, and only a small number of high-grade lesions were detected among the group of hrHPV positive cytology negative women who repeated testing 1-yr after baseline.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0969141314522219","type":"journal-article","created":{"date-parts":[[2014,1,31]],"date-time":"2014-01-31T23:05:01Z","timestamp":1391209501000},"page":"30-37","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":25,"title":["Cervical cancer screening by high risk HPV testing in routine practice: results at one year recall of high risk HPV-positive and cytology-negative women"],"prefix":"10.1177","volume":"21","author":[{"given":"Annarosa Del","family":"Mistro","sequence":"first","affiliation":[{"name":"Immunology and Molecular Oncology Unit, Veneto Oncology Institute IOV IRCCS, Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena","family":"Frayle","sequence":"additional","affiliation":[{"name":"Immunology and Molecular Oncology Unit, Veneto Oncology Institute IOV IRCCS, Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Ferro","sequence":"additional","affiliation":[{"name":"Department of Prevention; Local Health Unit 17 Este-Monselice, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanna","family":"Callegaro","sequence":"additional","affiliation":[{"name":"Department of Prevention; Local Health Unit 15 Alta padovana, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annamaria Del","family":"Sole","sequence":"additional","affiliation":[{"name":"Department of Prevention; Local Health Unit 19 Adria, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Stomeo","sequence":"additional","affiliation":[{"name":"Department of Prevention; Local Health Unit 18 Rovigo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuela","family":"Cirillo","sequence":"additional","affiliation":[{"name":"Department of Prevention; Local Health Unit 16 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Fedato","sequence":"additional","affiliation":[{"name":"Veneto Tumour Registry, Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvana","family":"Pagni","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, University of Padova, Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa","family":"Barzon","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, University of Padova, Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Zorzi","sequence":"additional","affiliation":[{"name":"Veneto Tumour Registry, Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,1,31]]},"reference":[{"key":"bibr1-0969141314522219","unstructured":"IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Human papillomaviruses (2005b). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans Vol. 90. 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Raccomandazioni sul test HR-HPV come test di screening primario e rivisitazione del ruolo del Pap test. Belluno: Evidenzia, 2010. 19p (Italian). http:\/\/www.gisci.it\/documenti\/documenti_gisci\/documento_hpv.pdf. 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