{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:07:31Z","timestamp":1777928851583,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2014,8,12]],"date-time":"2014-08-12T00:00:00Z","timestamp":1407801600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Med Screen"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the prevalence of \u03b1-thalassaemia in \u03b2-thalassaemia individuals in a Chinese population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The standard diagnostic marker for \u03b2-thalassaemia was elevation of the Hb A\n                      <jats:sub>2<\/jats:sub>\n                      level (&gt;3.5%) with low mean corpuscular volume. The common \u03b1-thalassaemia mutations were studied by molecular analysis in all identified \u03b2-thalassaemia carriers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A prevalence rate of 3.3% for \u03b2-thalassaemia was found in our population; \u03b1- and \u03b2-thalassaemia interactions were found to co-exist in 17.8% of the \u03b2-thalassaemia carriers. The -SEA deletion was the most common \u03b1-thalassaemia mutation co-inherited with \u03b2-thalassaemia, followed by the -\u03b13.7 deletion, the -\u03b14.2 deletion, Hb Quong Sze, and Hb Constant Spring.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our results suggest that it could be valuable to study co-existing \u03b1-globin mutations in subjects with \u03b2-thalassaemia trait in a prenatal screening programme, especially in populations with a high prevalence of haemoglobinopathies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0969141314548203","type":"journal-article","created":{"date-parts":[[2014,8,13]],"date-time":"2014-08-13T09:53:26Z","timestamp":1407923606000},"page":"167-171","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Co-inheritance of \u03b1-thalassaemia and \u03b2-thalassaemia in a prenatal screening population in mainland China"],"prefix":"10.1177","volume":"21","author":[{"given":"Jian","family":"Li","sequence":"first","affiliation":[{"name":"Prenatal Diagnostic Center, Guangzhou Women & Children Medical Center affiliated to Guangzhou Medical University, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing-Mei","family":"Xie","sequence":"additional","affiliation":[{"name":"Prenatal Diagnostic Center, Guangzhou Women & Children Medical Center affiliated to Guangzhou Medical University, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Can","family":"Liao","sequence":"additional","affiliation":[{"name":"Prenatal Diagnostic Center, Guangzhou Women & Children Medical Center affiliated to Guangzhou Medical University, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-Zhi","family":"Li","sequence":"additional","affiliation":[{"name":"Prenatal Diagnostic Center, Guangzhou Women & Children Medical Center affiliated to Guangzhou Medical University, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,8,12]]},"reference":[{"key":"bibr1-0969141314548203","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2003.014456"},{"key":"bibr2-0969141314548203","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1982.tb03916.x"},{"key":"bibr3-0969141314548203","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V62.1.226.226"},{"key":"bibr4-0969141314548203","doi-asserted-by":"publisher","DOI":"10.3109\/03630268408996958"},{"key":"bibr5-0969141314548203","doi-asserted-by":"crossref","unstructured":"Thein SL. 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