{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T15:12:47Z","timestamp":1788793967537,"version":"build-2803163510"},"reference-count":42,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2014,11,17]],"date-time":"2014-11-17T00:00:00Z","timestamp":1416182400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Med Screen"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Non-attenders for cervical screening are at increased risk of cervical cancer. Studies offering self-sampling for high-risk Human Papillomavirus (HrHPV) testing have shown greater uptake than sending another invitation for cytology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To explore whether uptake would increase in a less diverse, more stable population than the previous English study, which demonstrated a lower response rate than other studies. The primary objective was whether non-attenders were more likely to respond to a postal invitation, including kit, to collect a self-sample compared with a further invitation for cytology screening. The secondary objective was whether women with an abnormal result would attend for follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>6000 non-attenders for screening in this pragmatic, randomized (1:1) controlled trial in Newcastle-upon-Tyne were sent an HPV self-sample kit (intervention) or a further invitation for cytology screening (comparator).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>411(13%) responded to the intervention, returning a self-sample (247(8%)) or attending for cytology (164(5%)), compared with 183(6%) attending for cytology, relative risk 2.25 (95% CI 1.90\u20132.65) (comparator arm). Of those testing hrHPV positive (32(13%)), 19(59%) subsequently attended cytology screening. Of those in the intervention group who attended for cytology screening without returning an hrHPV self-sample (n\u2009=\u2009164), 5% (n\u2009=\u20098) were referred for colposcopy\u2009-\u2009all attended. In the comparator group eight of the nine referred for colposcopy attended.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Persistent non-responders to invitations for cervical screening are significantly more likely to respond to a postal invitation to return a self-collected sample for HPV testing than a further invitation for cytology screening. However, just over half followed up on this positive HPV result.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0969141314558785","type":"journal-article","created":{"date-parts":[[2014,11,17]],"date-time":"2014-11-17T22:11:36Z","timestamp":1416262296000},"page":"28-37","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":52,"title":["A randomized controlled trial in non-responders from Newcastle upon Tyne invited to return a self-sample for Human Papillomavirus testing versus repeat invitation for cervical screening"],"prefix":"10.1177","volume":"22","author":[{"given":"Louise","family":"Cadman","sequence":"first","affiliation":[{"name":"Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, St. Bartholomew\u2019s School of Medicine and Dentistry, London, EC1M 6BQ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Wilkes","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Health and Wellbeing, Faculty of Applied Sciences, Sciences Complex, City Campus, Chester Road, University of Sunderland, SR1 3SD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Mansour","sequence":"additional","affiliation":[{"name":"Newcastle Hospitals, Community Health, New Croft Centre, Market Street (East), Newcastle upon Tyne, NE1 6ND"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Austin","sequence":"additional","affiliation":[{"name":"Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, St. Bartholomew\u2019s School of Medicine and Dentistry, London, EC1M 6BQ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesley","family":"Ashdown-Barr","sequence":"additional","affiliation":[{"name":"Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, St. Bartholomew\u2019s School of Medicine and Dentistry, London, EC1M 6BQ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob","family":"Edwards","sequence":"additional","affiliation":[{"name":"Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, St. Bartholomew\u2019s School of Medicine and Dentistry, London, EC1M 6BQ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Kleeman","sequence":"additional","affiliation":[{"name":"Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, St. Bartholomew\u2019s School of Medicine and Dentistry, London, EC1M 6BQ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Szarewski","sequence":"additional","affiliation":[{"name":"Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, St. Bartholomew\u2019s School of Medicine and Dentistry, London, EC1M 6BQ"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,11,17]]},"reference":[{"key":"bibr1-0969141314558785","doi-asserted-by":"publisher","DOI":"10.1186\/2046-4053-2-35"},{"key":"bibr2-0969141314558785","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16674-9"},{"key":"bibr3-0969141314558785","unstructured":"NHS Cervical Screening Programme Statistical Bulletin, England 2012\u20132013. 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