{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:03:27Z","timestamp":1792062207961,"version":"4.4.0"},"reference-count":16,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2016,7,8]],"date-time":"2016-07-08T00:00:00Z","timestamp":1467936000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Med Screen"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the repercussions of recent changes to the cut-offs used in the first screening step of the pre-marital screening programme for thalassaemia prevention in Iran.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The profiles of 984 subjects referred to a genetic laboratory, and the tests of 242 parents of children with thalassaemia major were assessed for red blood cell (RBC) indices, haemoglobin (Hb) A2 levels and results of Hb electrophoresis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 407 suspected thalassaemia minor (STM) cases, 18 proved positive for thalassaemia minor on molecular analysis (18\/407, confidence interval 2.6\u20136.9%). If the revised screening cut-offs had been used to determine who would undergo molecular analysis, two of these cases would not have been identified. Only 4.4% of suspected cases with lower than normal RBC indices (mean corpuscular volume &lt;80\u2009fl and mean corpuscular Hb &lt;27\u2009pg) and HbA2 (&lt;3.5%) were diagnosed with thalassaemia minor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The thalassaemia major prevention programme is performed in two separate steps. One step involves the screening of subjects and identification of \u03b2-thalassaemia minor, suspected cases for thalassaemia minor (STM), and normal subject groups. The other step concerns the identification of thalassaemia minor in the STM group. Changing the cut-offs at the first screening step does not result in significant improvement from an economic view, and is associated with significant risk at the second screening step.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0969141316631007","type":"journal-article","created":{"date-parts":[[2016,3,18]],"date-time":"2016-03-18T20:47:38Z","timestamp":1458334058000},"page":"1-5","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["The pros and cons of the fourth revision of thalassaemia screening programme in Iran"],"prefix":"10.1177","volume":"24","author":[{"given":"Alireza","family":"Moafi","sequence":"first","affiliation":[{"name":"Department of Pediatric Hematology-Oncology, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reihaneh","family":"Vallian","sequence":"additional","affiliation":[{"name":"Sayed Al-shohada Hospital, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadeq","family":"Vallian","sequence":"additional","affiliation":[{"name":"Divisions of Genetics, Department of Biology, University of Isfahan, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soheila","family":"Rahgozar","sequence":"additional","affiliation":[{"name":"Divisions of Cellular and Molecular Biology, Department of Biology, University of Isfahan, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Torfenajad","sequence":"additional","affiliation":[{"name":"Sayed Al-shohada Hospital, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadi","family":"Moafi","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science, University of British Columbia, Vancouver, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,7,8]]},"reference":[{"key":"bibr1-0969141316631007","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.329.7475.1134"},{"key":"bibr2-0969141316631007","doi-asserted-by":"publisher","DOI":"10.1007\/s12687-013-0142-4"},{"key":"bibr3-0969141316631007","doi-asserted-by":"publisher","DOI":"10.1258\/jms.2012.012038"},{"key":"bibr4-0969141316631007","first-page":"67","volume":"41","author":"Miri-Moghaddam E","year":"2012","journal-title":"Iran J Public Health"},{"key":"bibr5-0969141316631007","first-page":"687","volume":"3","author":"Ahmadnezhad E","year":"2012","journal-title":"Int J Prev Med"},{"key":"bibr6-0969141316631007","first-page":"291","volume":"26","author":"Kalokairinou EM","year":"2007","journal-title":"Med Law"},{"key":"bibr7-0969141316631007","first-page":"739","volume":"92","author":"Pranpanus S","year":"2009","journal-title":"J Med Assoc Thai"},{"key":"bibr8-0969141316631007","doi-asserted-by":"publisher","DOI":"10.1159\/000091813"},{"key":"bibr9-0969141316631007","doi-asserted-by":"publisher","DOI":"10.5144\/0256-4947.2006.14"},{"key":"bibr10-0969141316631007","doi-asserted-by":"publisher","DOI":"10.1159\/000094688"},{"key":"bibr11-0969141316631007","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.08054.x"},{"key":"bibr12-0969141316631007","doi-asserted-by":"crossref","unstructured":"Penman BS, Gupta S and Weatherall DJ. 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