{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T21:20:09Z","timestamp":1792704009818,"version":"4.5.0"},"reference-count":10,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2016,10,9]],"date-time":"2016-10-09T00:00:00Z","timestamp":1475971200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Med Screen"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Renal cancer incidence has increased markedly in the United States in recent decades, largely due to incidentally detected tumours from computed tomography imaging. Here, we analyze the potential for low-dose computed tomography lung cancer screening to detect renal cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The National Lung Screening Trial randomized subjects to three annual screens with either low-dose computed tomography or chest X-ray. Eligibility criteria included 30\u2009+\u2009pack-years, current smoking or quit within 15 years, and age 55\u201374. Subjects were followed for seven years. Low-dose computed tomography screening forms collected information on lung cancer and non-lung cancer abnormalities, including abnormalities below the diaphragm. A reader study was performed on a sample of National Lung Screening Trial low-dose computed tomography images assessing presence of abnormalities below the diaphragms and abnormalities suspicious for renal cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There were 26,722 and 26,732 subjects enrolled in the low-dose computed tomography and chest X-ray arms, respectively, and there were 104 and 85 renal cancer cases diagnosed, respectively (relative risk\u2009=\u20091.22, 95% CI: 0.9\u20131.5). From 75,126 low-dose computed tomography screens, there were 46 renal cancer diagnoses within one year. Abnormalities below the diaphragm rates were 39.1% in screens with renal cancer versus 4.1% in screens without (P\u2009&lt;\u20090.001). Cases with abnormalities below the diaphragms had shorter median time to diagnosis than those without (71 vs. 160 days, P\u2009=\u20090.004). In the reader study, 64% of renal cancer cases versus 13% of non-cases had abnormalities below the diaphragms; 55% of cases and 0.8% of non-cases had a finding suspicious for renal cancer (P\u2009&lt;\u20090.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Low-dose computed tomography screens can potentially detect renal cancers. The benefits to harms tradeoff of incidental detection of renal tumours on low-dose computed tomography is unknown.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0969141316657115","type":"journal-article","created":{"date-parts":[[2016,10,11]],"date-time":"2016-10-11T11:38:22Z","timestamp":1476185902000},"page":"104-109","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Incidental renal tumours on low-dose CT lung cancer screening exams"],"prefix":"10.1177","volume":"24","author":[{"given":"Paul F","family":"Pinsky","sequence":"first","affiliation":[{"name":"Division of Cancer Prevention, National Cancer Institute, Bethesda, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Dunn","sequence":"additional","affiliation":[{"name":"Division of Cancer Prevention, National Cancer Institute, Bethesda, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Gierada","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P Hrudaya","family":"Nath","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham, Alabama, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reginald","family":"Munden","sequence":"additional","affiliation":[{"name":"Houston Methodist Hospital, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lincoln","family":"Berland","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham, Alabama, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barnett S","family":"Kramer","sequence":"additional","affiliation":[{"name":"Division of Cancer Prevention, National Cancer Institute, Bethesda, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,10,9]]},"reference":[{"key":"bibr1-0969141316657115","doi-asserted-by":"publisher","DOI":"10.7326\/M13-2771"},{"key":"bibr2-0969141316657115","unstructured":"Center for Medicare Services. National coverage analysis for screening for lung cancer with low dose computed tomography (LDCT), www.cms.gov\/medicare-coverage-database\/details\/nca-details.aspx?NCAId=274 (accessed 12 June 2016)."},{"key":"bibr3-0969141316657115","unstructured":"SEER \u2013 National Cancer Institute. SEER statistical summaries, www.seer.cancer.gov (accessed 12 June 2016)."},{"key":"bibr4-0969141316657115","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djj362"},{"key":"bibr5-0969141316657115","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(97)00506-2"},{"key":"bibr6-0969141316657115","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.10100640"},{"key":"bibr7-0969141316657115","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.10091808"},{"key":"bibr8-0969141316657115","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1102873"},{"key":"bibr9-0969141316657115","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2263020036"},{"key":"bibr10-0969141316657115","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.11102231"}],"container-title":["Journal of Medical Screening"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0969141316657115","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0969141316657115","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0969141316657115","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:23:56Z","timestamp":1777677836000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0969141316657115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,9]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1177\/0969141316657115"],"URL":"https:\/\/doi.org\/10.1177\/0969141316657115","relation":{},"ISSN":["0969-1413","1475-5793"],"issn-type":[{"value":"0969-1413","type":"print"},{"value":"1475-5793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,9]]}}}