{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:08:59Z","timestamp":1777928939171,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2017,5,3]],"date-time":"2017-05-03T00:00:00Z","timestamp":1493769600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["A16894"],"award-info":[{"award-number":["A16894"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Med Screen"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The English Bowel Cancer Screening Programme offers biennial guaiac faecal occult blood test (gFOBT) screening to 60\u201374-year-olds. Participants with positive results are referred for follow-up, but many do not have significant findings. If they remain age eligible, these individuals are reinvited for gFOBT screening. We evaluated the performance of repeat screening in this group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analysed data on programme participants reinvited to gFOBT screening after either previous negative gFOBT ( n\u2009=\u2009327,542), or positive gFOBT followed by a diagnostic investigation negative for colorectal cancer (CRC) or adenomas requiring surveillance ( n\u2009=\u200942,280). Outcomes calculated were uptake, test positivity, yield of CRC, and positive predictive value (PPV) of gFOBT for CRC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>For participants with a previous negative gFOBT, uptake in the subsequent screening round was 87.5%, positivity was 1.3%, yield of CRC was 0.112% of those adequately screened, and the PPV of gFOBT for CRC was 9.1%. After a positive gFOBT and a negative diagnostic investigation, uptake in the repeat screening round was 82.6%, positivity was 11.3%, CRC yield was 0.172% of participants adequately screened, and the PPV of gFOBT for CRC was 1.7%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>With high positivity and low PPV for CRC, the suitability of routine repeat gFOBT screening in two years among individuals with a previous positive test and a negative diagnostic examination needs to be carefully considered.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0969141317698501","type":"journal-article","created":{"date-parts":[[2017,5,3]],"date-time":"2017-05-03T09:46:30Z","timestamp":1493804790000},"page":"70-75","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["High test positivity and low positive predictive value for colorectal cancer of continued faecal occult blood test screening after negative colonoscopy"],"prefix":"10.1177","volume":"25","author":[{"given":"Jeremy P","family":"Brown","sequence":"first","affiliation":[{"name":"Cancer Screening and Prevention Research Group, Department of Surgery and Cancer, Imperial College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate","family":"Wooldrage","sequence":"additional","affiliation":[{"name":"Cancer Screening and Prevention Research Group, Department of Surgery and Cancer, Imperial College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne","family":"Wright","sequence":"additional","affiliation":[{"name":"NHS Cancer Screening Programmes, Fulwood House, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Nickerson","sequence":"additional","affiliation":[{"name":"NHS Cancer Screening Programmes, Fulwood House, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda J","family":"Cross","sequence":"additional","affiliation":[{"name":"Cancer Screening and Prevention Research Group, Department of Surgery and Cancer, Imperial College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy S","family":"Atkin","sequence":"additional","affiliation":[{"name":"Cancer Screening and Prevention Research Group, Department of Surgery and Cancer, Imperial College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,5,3]]},"reference":[{"key":"bibr1-0969141317698501","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2008.01875.x"},{"key":"bibr2-0969141317698501","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.179804"},{"key":"bibr3-0969141317698501","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-300843"},{"key":"bibr4-0969141317698501","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-301531"},{"key":"bibr5-0969141317698501","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-308362"},{"key":"bibr6-0969141317698501","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)70214-2"},{"issue":"1","key":"bibr7-0969141317698501","doi-asserted-by":"crossref","first-page":"A77","DOI":"10.1136\/gutjnl-2014-307127","volume":"64","author":"Burke E","year":"2015","journal-title":"Gut"},{"key":"bibr8-0969141317698501","unstructured":"Campari C, Camellini L, Sereni G, et al. Efficacy of FIT 5 years after a negative colonoscopy and a previous positive FIT: Results from a screening cohort.\n                      Digest Liver Dis\n                      2015; 47: e145."},{"key":"bibr9-0969141317698501","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2011.02849.x"},{"key":"bibr10-0969141317698501","first-page":"112","volume":"28","author":"Harma C","year":"2013","journal-title":"J Gastroen Hepatol"},{"issue":"2","key":"bibr11-0969141317698501","first-page":"A328","volume":"61","author":"Majumdar D","year":"2012","journal-title":"Gut"},{"issue":"2","key":"bibr12-0969141317698501","first-page":"A160","volume":"61","author":"Nylander D","year":"2012","journal-title":"Gut"},{"key":"bibr13-0969141317698501","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(09)60135-9"},{"key":"bibr14-0969141317698501","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2013.06.197"},{"key":"bibr15-0969141317698501","doi-asserted-by":"crossref","unstructured":"Sehgal V, Stein J, Bloom S, et al. Do patients with a previous normal colonoscopy within the United Kingdom Bowel Cancer Screening Program who subsequently have a positive FOBT require colonoscopy?\n                      Gut\n                      2014; 63(S1): A22\u2013A23.","DOI":"10.1136\/gutjnl-2014-307263.46"},{"key":"bibr16-0969141317698501","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-306144"},{"key":"bibr17-0969141317698501","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2006.01.021"},{"key":"bibr18-0969141317698501","doi-asserted-by":"publisher","DOI":"10.1159\/000334372"},{"key":"bibr19-0969141317698501","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-010-1150-4"},{"key":"bibr20-0969141317698501","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2016.06.011"},{"key":"bibr21-0969141317698501","first-page":"229","volume":"56","author":"Konrad G","year":"2010","journal-title":"Can Fam Phys"},{"issue":"1","key":"bibr22-0969141317698501","first-page":"A76","volume":"64","author":"Derbyshire E","year":"2015","journal-title":"Gut"},{"key":"bibr23-0969141317698501","doi-asserted-by":"crossref","unstructured":"Tam MS and Abbas MA. Perforation following colorectal endoscopy: What happens beyond the endoscopy suite?\n                      The Permanente J\n                      2013; 17: 17\u201321.","DOI":"10.7812\/TPP\/12-095"},{"key":"bibr24-0969141317698501","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3999(92)90051-3"},{"key":"bibr25-0969141317698501","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-013-1867-7"},{"key":"bibr26-0969141317698501","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2015.365"}],"container-title":["Journal of Medical Screening"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0969141317698501","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0969141317698501","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0969141317698501","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:24:07Z","timestamp":1777677847000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0969141317698501"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,3]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1177\/0969141317698501"],"URL":"https:\/\/doi.org\/10.1177\/0969141317698501","relation":{},"ISSN":["0969-1413","1475-5793"],"issn-type":[{"value":"0969-1413","type":"print"},{"value":"1475-5793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,3]]}}}