{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:08:43Z","timestamp":1777928923675,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2017,7,7]],"date-time":"2017-07-07T00:00:00Z","timestamp":1499385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Med Screen"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To compare the outcomes of sickle cell disease patients diagnosed through neonatal screening with those who were not.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In an observational multicenter study in Belgium, 167 screened and 93 unscreened sickle cell disease patients were analyzed for a total of 1116 and 958 patient-years of follow-up, respectively. Both groups were compared with propensity score analysis, with patients matched on three covariates (gender, genotype, and central Africa origin). Bonferroni correction was applied for all comparisons.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Kaplan\u2013Meier estimates of survival without bacteremia were significantly higher in the screened group than the unscreened group (94.47%; [95% CI, 88.64\u201397.36%] versus 83.78% [95% CI, 72.27\u201390.42%]), p\u2009=\u20090.032. Non-significant differences between both groups were reported for survival without acute chest syndrome, acute anemia, cerebral complication, severe infection, and vaso-occlusive crisis. Significantly lower hospitalization rate and days per 100 patient-years were observed in the screened compared with the unscreened group (0.27 vs. 0.63 and 1.25 vs. 2.82, p\u2009=\u20090.0006 and &lt;0.0001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These data confirm the benefit of a neonatal screening programme in reducing bacteremia and hospitalization.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0969141317701166","type":"journal-article","created":{"date-parts":[[2017,12,31]],"date-time":"2017-12-31T04:27:49Z","timestamp":1514694469000},"page":"57-63","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Neonatal screening improves sickle cell disease clinical outcome in Belgium"],"prefix":"10.1177","volume":"25","author":[{"given":"Phu-Quoc","family":"L\u00ea","sequence":"first","affiliation":[{"name":"Hemato-Oncology, Hopital Universitaire des Enfants Reine Fabiola, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alina","family":"Ferster","sequence":"additional","affiliation":[{"name":"Hemato-Oncology, Hopital Universitaire des Enfants Reine Fabiola, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence","family":"Dedeken","sequence":"additional","affiliation":[{"name":"Hemato-Oncology, Hopital Universitaire des Enfants Reine Fabiola, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christiane","family":"Vermylen","sequence":"additional","affiliation":[{"name":"Hemato-Oncology, Cliniques Universitaires Saint-Luc, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Vanderfaeillie","sequence":"additional","affiliation":[{"name":"Pediatrics, Centre Hospitalier Universitaire Saint-Pierre, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence","family":"Rozen","sequence":"additional","affiliation":[{"name":"Laboratory of Hematology and Hemostasis, Centre Hospitalier Universitaire de Brugmann, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Heijmans","sequence":"additional","affiliation":[{"name":"Hemato-Oncology, Hopital Universitaire des Enfants Reine Fabiola, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Huybrechts","sequence":"additional","affiliation":[{"name":"Hemato-Oncology, Hopital Universitaire des Enfants Reine Fabiola, Brussels, 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Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Fran\u00e7ois","family":"Fils","sequence":"additional","affiliation":[{"name":"Independant Biostatistician \u2013 Ars Statistica, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e9atrice","family":"Gulbis","sequence":"additional","affiliation":[{"name":"Clinical Chemistry, Erasme Hospital, Brussels, 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