{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:57:38Z","timestamp":1789581458611,"version":"build-2803163510"},"reference-count":10,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T00:00:00Z","timestamp":1564012800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007192","name":"Rijksinstituut voor Volksgezondheid en Milieu","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007192","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Med Screen"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Several studies have shown that there is an upward shift in the classification of cervical cytology when high-risk human papillomavirus (hrHPV) status is known to be positive. The Netherlands implemented primary hrHPV screening with reflex cytology as the primary screening test in 2017. Prior to implementation of the new programme, we investigated whether knowledge of hrHPV status influences cytology rating.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using a set of 200 cytology slides that had been previously tested, two pairs of cytotechnicians rated 100 slides per pair twice: first without knowledge of hrHPV status and then, after a wash-out period of two months, with knowledge of hrHPV status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We found that hrHPV positive slides were more likely to be rated up over the referral threshold (i.e. from negative for intraepithelial lesion or malignancy to atypical squamous cells of undetermined significance+) than hrHPV negative slides at the second review when hrHPV status was known (relative risk\u2009=\u20093.2; 95% confidence interval: 1.3\u20137.9).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>If the same upward shift in ratings were to be observed in the national programme, it may have implications for referrals of women with low-grade lesions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0969141319864991","type":"journal-article","created":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T05:18:13Z","timestamp":1564031893000},"page":"221-224","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["The impact of knowledge of HPV positivity on cytology triage in primary high-risk HPV screening"],"prefix":"10.1177","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9973-7376","authenticated-orcid":false,"given":"Clare A","family":"Aitken","sequence":"first","affiliation":[{"name":"Department of Public Health, Erasmus MC University Medical Center, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim M","family":"Holtzer-Goor","sequence":"additional","affiliation":[{"name":"Dutch National Institute for Public Health and the Environment, Centre for Population Screening, Bilthoven, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Uyterlinde","sequence":"additional","affiliation":[{"name":"Facilitaire Samenwerking Bevolkingsonderzoeken, Utrecht, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriaan JC","family":"van den Brule","sequence":"additional","affiliation":[{"name":"Jeroen Bosch Hospital, Pathologie-DNA, \u2018s-Hertogenbosch, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans C","family":"van der Linden","sequence":"additional","affiliation":[{"name":"Jeroen Bosch Hospital, Pathologie-DNA, \u2018s-Hertogenbosch, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelis J","family":"Huijsmans","sequence":"additional","affiliation":[{"name":"Jeroen Bosch Hospital, Pathologie-DNA, \u2018s-Hertogenbosch, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge MCM","family":"de Kok","sequence":"additional","affiliation":[{"name":"Department of Public Health, Erasmus MC University Medical Center, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Folkert J","family":"van Kemenade","sequence":"additional","affiliation":[{"name":"Department of Pathology, Erasmus MC University Medical Center, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,7,25]]},"reference":[{"key":"bibr1-0969141319864991","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.06.101"},{"key":"bibr2-0969141319864991","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dju423"},{"key":"bibr3-0969141319864991","first-page":"60","volume":"125","author":"Doxtader EE","year":"2017","journal-title":"Cancer"},{"key":"bibr4-0969141319864991","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2012-0115-CP"},{"key":"bibr5-0969141319864991","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21596"},{"key":"bibr6-0969141319864991","doi-asserted-by":"publisher","DOI":"10.1002\/dc.22829"},{"key":"bibr7-0969141319864991","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-016-2961-2"},{"key":"bibr8-0969141319864991","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-014-0414-2"},{"key":"bibr9-0969141319864991","unstructured":"Erasmus MC. PALGA. Monitor 2015: Bevolkingsonderzoek Baarmoederhalskanker (in Dutch). https:\/\/www.rivm.nl\/sites\/default\/files\/2018-11\/LEBA-rapp-tm2015.pdf (2016, accessed 10 December 2018)."},{"key":"bibr10-0969141319864991","unstructured":"Erasmus MC. PALGA. Monitor 2017: Bevolkingsonderzoek Baarmoederhalskanker (in Dutch). https:\/\/www.rivm.nl\/sites\/default\/files\/2018-11\/LEBAmon2017-def.pdf (2018, accessed 10 December 2018)."}],"container-title":["Journal of Medical Screening"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0969141319864991","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0969141319864991","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0969141319864991","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:24:31Z","timestamp":1777677871000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0969141319864991"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,25]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1177\/0969141319864991"],"URL":"https:\/\/doi.org\/10.1177\/0969141319864991","relation":{},"ISSN":["0969-1413","1475-5793"],"issn-type":[{"value":"0969-1413","type":"print"},{"value":"1475-5793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,25]]}}}