{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:10:10Z","timestamp":1777929010072,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T00:00:00Z","timestamp":1582675200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Agenzia Sanitaria Abruzzo","award":["CCM 2009"],"award-info":[{"award-number":["CCM 2009"]}]},{"DOI":"10.13039\/501100009882","name":"Regione Lombardia","doi-asserted-by":"crossref","award":["DRG N.10813 del 16.12.2009"],"award-info":[{"award-number":["DRG N.10813 del 16.12.2009"]}],"id":[{"id":"10.13039\/501100009882","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Med Screen"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To present performance indicators from the second round of the Vallecamonica-Sebino HPV screening programme in women who had tested negative about four years earlier (mean 45\u2009months).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From 2010 to 2012, the target female population (aged 25\u201364) was invited to the first HPV screening round. In 2013\u20132017, women were rescreened for the second round. HPV-negative women at the first round were initially rescreened after three years. The interval was gradually increased to five years. HPV-positive women underwent cytology triage: positives were referred to colposcopy and negatives to repeat testing after one year. If HPV was persistently positive, women were referred to colposcopy, if negative, to normal interval rescreening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the second round, of 13,824 previously HPV-negative women, 598 were HPV-positive (4.3%), of whom 297 were positive at cytology triage. Of those referred to one-year HPV test, 291 complied (98.0%), 133 (50.2%) of whom were persistently positive. Total referral was 3.1% compared with 6.6% in the first round (age-adjusted relative referral 0.59, 95% CI: 0.53\u20130.65). There were 24 cervical intraepithelial neoplasia 2+ (three cervical intraepithelial neoplasia 3+). Detection was 0.17%, compared with 0.9% in the first round. Age-adjusted relative detections were 0.25 (95% CI: 0.16\u20130.39) and 0.18 (95% CI: 0.05\u20130.61) for cervical intraepithelial neoplasia 2+ and cervical intraepithelial neoplasia 3+, respectively. Positive predictive value was 5.7%, compared with 14.6% in the first round.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>At second round, referral was half that at first round, while cervical intraepithelial neoplasia 2+ detection decreased nine-fold. Consequently, positive predictive value decreased dramatically. Rescreening four years after an HPV-negative test makes the process inefficient due to the low prevalence of lesions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0969141320905325","type":"journal-article","created":{"date-parts":[[2020,2,27]],"date-time":"2020-02-27T00:52:02Z","timestamp":1582764722000},"page":"207-214","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["HPV screening performance indicators in women who previously tested HPV-negative: The second round of Vallecamonica screening programme, Northern Italy"],"prefix":"10.1177","volume":"27","author":[{"given":"Luigi","family":"Pasquale","sequence":"first","affiliation":[{"name":"Former responsible for screening ex ASL Vallecamonica-Sebino, Regione Lombardia, Breno, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9703-2460","authenticated-orcid":false,"given":"Paolo G","family":"Rossi","sequence":"additional","affiliation":[{"name":"Epidemiology Unit, Azienda USL \u2013 IRCCS di Reggio Emilia, Reggio Emilia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Carozzi","sequence":"additional","affiliation":[{"name":"S.C. 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Laboratorio di Prevenzione Oncologica, Istituto per lo Studio e la Prevenzione Oncologica, Firenze, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,2,26]]},"reference":[{"key":"bibr1-0969141320905325","first-page":"e1","volume":"36","author":"Ronco G","year":"2012","journal-title":"Epidemiol Prev"},{"key":"bibr2-0969141320905325","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61450-0"},{"key":"bibr3-0969141320905325","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa073204"},{"key":"bibr4-0969141320905325","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70296-0"},{"key":"bibr5-0969141320905325","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70360-2"},{"key":"bibr6-0969141320905325","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)62218-7"},{"key":"bibr7-0969141320905325","doi-asserted-by":"crossref","unstructured":"Ronco G, Arbyn M, Meijer CJLM, et al. 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