{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:08:56Z","timestamp":1777928936543,"version":"3.51.4"},"reference-count":42,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T00:00:00Z","timestamp":1652659200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Med Screen"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Roll-out of population-based colorectal cancer (CRC) screening with faecal immunochemical test (FIT) is limited by availability of further investigations, particularly colonoscopy and examination of excised lesions. Our objective was to assess whether variation in number of faecal samples and threshold adjustment can optimise resource utilisation and CRC detection rate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Three different screening strategies were compared for the same FIT threshold using a quantitative FIT system: one FIT, positive when &gt;20\u2005\u00b5g Hb\/g faeces; two FIT, positive when either was &gt;20\u2005\u00b5g Hb\/g faeces; and two FIT, positive when the mean was &gt;20\u2005\u00b5g Hb\/g faeces. We calculated changes in the size of population the provider could invite to screening for an equal number of screening positive results, and CRC and adenoma detected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In our setting, Region of Murcia, south of Spain (not fully rolled out screening programme), changing the usual strategy of two FIT, positive when either to positive when the mean was &gt;20\u2005\u00b5g Hb\/g faeces, would increase population invited by 37.81% with the same number of positive results (which would generate a CRC detection rate of 19.2%). In a fully rolled out programme, changing the strategy from one to two FIT (positive when the mean is &gt;20\u2005\u00b5g Hb\/g faeces), would increase CRC detection rate by 4.64% with an increase of only 13.34% in positive FIT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In a population-based CRC screening programme, smart use of number of FITs and positivity threshold can increase population invited and CRC detection without increasing the number of colonoscopies and pathological examinations needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09691413221094919","type":"journal-article","created":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T17:24:33Z","timestamp":1652894673000},"page":"231-240","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["One or two faecal immunochemical tests in an organised population-based colorectal cancer screening programme in Murcia (Spain)"],"prefix":"10.1177","volume":"29","author":[{"given":"Carlos","family":"Tourne-Garcia","sequence":"first","affiliation":[{"name":"Servicio de Promoci\u00f3n y Educaci\u00f3n para la Salud, Direcci\u00f3n General de Salud P\u00fablica, Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Perez-Riquelme","sequence":"additional","affiliation":[{"name":"Servicio de Promoci\u00f3n y Educaci\u00f3n para la Salud, Direcci\u00f3n General de Salud P\u00fablica, Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga","family":"Monteagudo-Piqueras","sequence":"additional","affiliation":[{"name":"Servicio de Promoci\u00f3n y Educaci\u00f3n para la Salud, Direcci\u00f3n General de Salud P\u00fablica, Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1333-7994","authenticated-orcid":false,"given":"Callum G","family":"Fraser","sequence":"additional","affiliation":[{"name":"Centre for Research into Cancer Prevention and Screening, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9061-6217","authenticated-orcid":false,"given":"Pedro","family":"Yepes-Garcia","sequence":"additional","affiliation":[{"name":"Preventive Medicine, Hospital Rafael M\u00e9ndez, Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,5,16]]},"reference":[{"key":"bibr1-09691413221094919","first-page":"1","volume":"66","author":"Kim I","year":"2020","journal-title":"IARC. 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