{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T08:16:03Z","timestamp":1788336963726,"version":"build-2803163510"},"reference-count":21,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T00:00:00Z","timestamp":1727654400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Med Screen"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Biliary atresia (BA) is a liver disease of infancy characterized by obstruction of the biliary tree. Infants with BA have the best outcomes when identified early and the Kasai portoenterostomy is performed before 45 days of life (DoL). In our hospital system, the average age at Kasai was 60 DoL. To address the problem of late presentation, we implemented a two-stage BA screening strategy utilizing direct bilirubin (DB).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>New institutional policies were established that all newborns were tested at 24\u201348 h of life, and those with levels \u22650.5 mg\/dL were followed further. The infant's primary care provider was contacted to recommend a repeat DB at 2 weeks of life. If the repeat DB was \u22651.0 mg\/dL, the patient was evaluated by gastroenterology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Over the 16\u2005months, 3880 infants were born and 3861 (99.5%) were screened; 53 infants (1.3%) had DB levels \u22650.5 mg\/dL initially. Upon repeat testing at 2 weeks, there were three groups of infants: not retested (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091), retested &lt;1.0 mg\/dL (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200940), and retested \u22651.0 mg\/dL (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200912). The average time to be seen by gastroenterology was 4.3 days or 18.3 DoL.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>The screening included a series of steps that needed to be implemented effectively. Screening had a net false positive rate of 0.3% (12 out of 3861) and identified causes of cholestasis other than BA. BA was excluded by 28 DoL on average. Our results can provide a template for other institutions interested in implementing a BA screening protocol in their practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09691413241284243","type":"journal-article","created":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T02:56:43Z","timestamp":1727751403000},"page":"61-66","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Newborn screening for biliary atresia using direct bilirubin: An implementation science study"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6307-4774","authenticated-orcid":false,"given":"Tebyan","family":"Rabbani","sequence":"first","affiliation":[{"name":"Lucile Salter Packard Children's Hospital at Stanford, Palo Alto, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay","family":"Shah","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, UT Health San Antonio, San Antonio, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,9,30]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29905"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2017.05.006"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21790"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.09.061"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-1949"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.11613\/BM.2016.001"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-021-00825-2"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-3570"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2014.12.063"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-019-04526-w"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-1267"},{"key":"e_1_3_2_13_2","first-page":"2","article-title":"Newborn biliary atresia screening with the stool colour card: A questionnaire survey of parents","author":"Borgeat M","year":"2018","unstructured":"Borgeat M, Korff S, Wildhaber BE. Newborn biliary atresia screening with the stool colour card: A questionnaire survey of parents. BMJ Paediatr Open 2018: 2: e000269.","journal-title":"BMJ Paediatr Open"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199809000-00007"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.0837"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001887"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-021-07398-w"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.12968\/hmed.2015.76.1.46"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1542\/hpeds.2020-0148"},{"key":"e_1_3_2_20_2","first-page":"23","article-title":"Usability of electronic health record-generated discharge summaries: Heuristic evaluation","author":"Tremoulet PD","year":"2021","unstructured":"Tremoulet PD, Shah PD, Acosta AA, et al. Usability of electronic health record-generated discharge summaries: Heuristic evaluation. J Med Internet Res 2021: 23: e25657.","journal-title":"J Med Internet Res"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.114.1.297"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001950"}],"container-title":["Journal of Medical Screening"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09691413241284243","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09691413241284243","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09691413241284243","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:26:14Z","timestamp":1777677974000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09691413241284243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,30]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1177\/09691413241284243"],"URL":"https:\/\/doi.org\/10.1177\/09691413241284243","relation":{},"ISSN":["0969-1413","1475-5793"],"issn-type":[{"value":"0969-1413","type":"print"},{"value":"1475-5793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,30]]}}}