{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T08:01:02Z","timestamp":1789891262161,"version":"4.0.1"},"reference-count":34,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100013392","name":"Minist\u00e8re de la Sant\u00e9 et des Services sociaux","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021219","name":"Partenariat Canadien Contre Le Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021219","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Med Screen"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>A Lung Cancer Screening Demonstration Project using low-dose computed tomography (LDCT) was launched in Quebec, Canada to inform province-wide lung cancer screening implementation. This study analyses key performance indicators of the screening pathway.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      High-risk smokers and ex-smokers were referred or self-referred for screening. Eligibility was based on the Prostate, Lung, Colorectal and Ovarian (PLCOm2012\n                      <jats:sub>noRace<\/jats:sub>\n                      ) 6-year risk (\u22652%). Lung-RADS 3 and Lung-RADS 4 rates, lung cancer detection and false-positive rates, and early-stage cancer proportion (TNM stages I and II), along with other performance indicators, were computed for the two first screening rounds.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Between June 2021 and November 2022, 8416 individuals were referred to the project, and 4422 were eligible (53.4%; target \u226550%). The first 3200 participants were included in the study. Mean PLCOm2012\n                      <jats:sub>noRace<\/jats:sub>\n                      risk was 5.2%. In round 1, Lung-RADS 4 occurred in 6.8% of participants (target \u226410%), with a cancer detection rate of 1.7% (target \u22651.5%), and a false-positive rate of 5.3% (target \u226410%). In round 2, Lung-RADS 4 rate was 4.0% (target \u22645%), with a cancer detection rate of 0.8% (target \u22650.7%), and a false-positive rate of 3.2% (target \u22645%). Early stage cancers accounted for 85.2% in round 1 and 84.2% in round 2 (target \u226570%). Adherence to the next screening among Lung-RADS 1 or 2 participants was \u226581% across both rounds (target \u226570%). Overall, 91.1% of screen-detected cancers received curative treatment (target \u226565%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Results showed good performance strengthening evidence on key indicators pertaining to benefits and harms of lung cancer screening within a provincial public health care system.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09691413261481721","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T03:33:32Z","timestamp":1789702412000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Risk-based lung cancer screening with low-dose computed tomography in a Canadian province: Evaluation results of a demonstration project in Quebec, Canada"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0355-0118","authenticated-orcid":false,"given":"Jos\u00e9","family":"Massougbodji","sequence":"first","affiliation":[{"name":"Institut national de sant\u00e9 publique du Qu\u00e9bec (INSPQ), Bureau d'information et d'\u00e9tudes en sant\u00e9 des populations"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Rodrigue","sequence":"additional","affiliation":[{"name":"Institut national de sant\u00e9 publique du Qu\u00e9bec (INSPQ), Bureau d'information et d'\u00e9tudes en sant\u00e9 des populations"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5454-1334","authenticated-orcid":false,"given":"Simon","family":"Martel","sequence":"additional","affiliation":[{"name":"Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec (IUCPQ), Universit\u00e9 Laval, Quebec City, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Lizotte","sequence":"additional","affiliation":[{"name":"Minist\u00e8re de la Sant\u00e9 et des Services sociaux, Direction de la canc\u00e9rologie, Quebec City, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2777-9961","authenticated-orcid":false,"given":"Isabelle","family":"Th\u00e9berge","sequence":"additional","affiliation":[{"name":"Institut national de sant\u00e9 publique du Qu\u00e9bec (INSPQ), Bureau d'information et d'\u00e9tudes en sant\u00e9 des populations"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gino","family":"Boily","sequence":"additional","affiliation":[{"name":"Institut national d\u2019excellence en sant\u00e9 et en services sociaux (INESSS), Direction de l\u2019\u00e9valuation et de la pertinence des modes d\u2019intervention en sant\u00e9, Quebec City, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1803-6418","authenticated-orcid":false,"given":"Nicole","family":"Ezer","sequence":"additional","affiliation":[{"name":"Centre Universitaire de Sant\u00e9 McGill, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Bouchard","sequence":"additional","affiliation":[{"name":"Centre hospitalier universitaire de Sherbrooke (CHUS), Sherbrooke, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8881-8697","authenticated-orcid":false,"given":"Marie-H\u00e9l\u00e8ne","family":"Guertin","sequence":"additional","affiliation":[{"name":"Institut national de sant\u00e9 publique du Qu\u00e9bec (INSPQ), Bureau d'information et d'\u00e9tudes en sant\u00e9 des populations"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"Canadian Cancer Society. 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