{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T06:02:20Z","timestamp":1790488940259,"version":"4.1.0"},"reference-count":27,"publisher":"SAGE Publications","issue":"2-3","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurosciences"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Postural instability is a common problem in patients with Parkinson\u2019s disease (PD). The appropriate cooperation of vestibular, visual, and proprioceptive signals along with apt anticipatory and adaptive postural responses is essential for postural stability. Abnormalities in this sensorimotor admixture lead to postural instability in PD. The function of vestibular otolith function and its central connections in postural instability of PD is still obscure. Cervical vestibular-evoked myogenic potentials (VEMP) can be used to assess the function of the saccular part of otolith and its connections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>We aimed to study the role of dysfunction of the saccule and its connections at the brainstem by comparing the VEMP with normal controls and correlating it with the postural instability in patients with PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty patients with PD and 30 healthy volunteers were included in the study, after obtaining the institutional ethical committee approval. Patient\u2019s demographic data, stage and duration of illness, treatment history, history of fall, postural instability, Unified Parkinson\u2019s Disease Rating Scale (UPDRS) score, and Non-Motor Symptoms Scales (NMSs) were noted. Cervical VEMP analysis was done for both patients and controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results and Conclusion<\/jats:title>\n                    <jats:p>Patients with absent VEMP had significant postural instability, a history of falls, and a high UPDRS score. Mean P13 and N23 latencies were prolonged, and the amplitude was significantly low in patients with PD. Absent cVEMP was significantly associated with postural instability, non-motor symptoms, especially gastrointestinal, miscellaneous symptoms, and mood\/cognition. VEMP can be considered an early electrophysiological marker for dysfunction of otolith and its central connections.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09727531221106664","type":"journal-article","created":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T23:48:55Z","timestamp":1657064935000},"page":"137-143","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Association of Cervical Vestibular-Evoked Myogenic Potentials (VEMP) and Postural Instability in Patients with Parkinson\u2019s Disease: A Cross-Sectional Study"],"prefix":"10.1177","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1380-4679","authenticated-orcid":false,"given":"Archana","family":"Gaur","sequence":"first","affiliation":[{"name":"Department of Physiology, All India Institute of Medical Sciences-Bibinagar, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravichandran","family":"Rajamanickam","sequence":"additional","affiliation":[{"name":"Department of Neurology, Kauvery Hospital, Tiruchirappalli, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chennappan","family":"Chinnathambi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Dhanalakshmi Srinivasan Medical College and Hospital, Perambalur, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divya","family":"Selvaraju","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, KAP Viswanatham Government Medical College, Tiruchirappalli, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5691-670X","authenticated-orcid":false,"given":"Varatharajan","family":"Sakthivadivel","sequence":"additional","affiliation":[{"name":"Department of General Medicine, All India Institute of Medical Sciences-Bibinagar, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,7,5]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1159\/000445751"},{"key":"e_1_3_5_3_2","first-page":"e906274","article-title":"Recurrent falls in Parkinson\u2019s disease: A systematic review","volume":"2013","author":"Allen NE","year":"2013","unstructured":"Allen NE, , Schwarzel AK, , and Canning CG. 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J Neurol January 2016; 263(1) https:\/\/pubmed.ncbi.nlm.nih.gov\/26530511\/ (Accessed February 9 2022).","DOI":"10.1007\/s00415-015-7950-x"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/0471142301.ns1001s49"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20513"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neucli.2009.07.001"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25061"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2014.12.017"},{"key":"e_1_3_5_21_2","doi-asserted-by":"crossref","unstructured":"Shalash AS Hassan DM Elrassas HH . Auditory- and vestibular-evoked potentials correlate with motor and non-motor features of Parkinson\u2019s disease. 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