{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T23:33:57Z","timestamp":1780702437819,"version":"3.54.1"},"reference-count":30,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T00:00:00Z","timestamp":1744934400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T00:00:00Z","timestamp":1744934400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurosciences"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Tuberculous meningitis (TBM) is a severe form of tuberculosis (TB) that affects the meninges, frequently causing major neurological problems. Timely diagnosis and care are crucial to avoid unfavourable consequences, particularly in vulnerable populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This case report aims to highlight the diagnostic problems and management complications of TBM, especially when combined with rare neurological events such as acute ischaemic stroke (AIS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      An 84-year-old female presented with disorientation, seizures, aphasia and hemiparesis. The initial imaging revealed normotensive hydrocephalus and bilateral delta activity on the electroencephalogram (EEG). Despite anti-fungal treatment, CT imaging revealed widespread inflammatory alterations. Sputum and cerebrospinal fluid (CSF) tests were done and revealed the presence of\n                      <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                      . MRI indicated several acute lesions, which are symptomatic of TBM.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The patient developed AIS, a relatively rare complication of TBM. Treatment was initiated with a combination of anti-TB drugs and corticosteroids. While corticosteroids reduced inflammation and mortality risk, their potential to contribute to long-term disability was noted as an area of concern.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case underscores the critical role of MRI in the early detection of TBM-related complications. Although corticosteroids improve short-term outcomes, their impact on long-term disability necessitates further research. Effective management strategies tailored to vulnerable populations are essential to improve the prognosis of TBM patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09727531251322546","type":"journal-article","created":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T07:08:11Z","timestamp":1745046491000},"page":"295-301","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["A Case Report of Acute Ischaemic Stroke Associated with T\u200buberculous Meningitis"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2943-6404","authenticated-orcid":false,"given":"Harsahaj Singh","family":"Wilkhoo","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Tbilisi State Medical University, Tbilisi, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanshi","family":"Gundaniya","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Tbilisi State Medical University, Tbilisi, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3914-0186","authenticated-orcid":false,"given":"Harshavardhini","family":"Visvanathan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Tbilisi State Medical University, Tbilisi, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swastika","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Tbilisi State Medical University, Tbilisi, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Dzagnidze","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Tbilisi State Medical University, Tbilisi, Georgia"},{"name":"Neurologist, S. Khechinashvili University Hospital, Tbilisi, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,4,18]]},"reference":[{"key":"e_1_3_9_2_2","unstructured":"Tuberculous Meningitis Clinical Presentation: History Physical Examination Complications. https:\/\/emedicine.medscape.com\/article\/1166190-clinical?form=fpf%202.Usha%20Kant%20Misra%201 %20Jayantee%20Kalita %20Pradeep%20Kumar%20Maurya%20https:\/\/pubmed.ncbi.nlm.nih.gov\/21272895\/ (accessed 15 August 2024)."},{"key":"e_1_3_9_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2010.12.015"},{"key":"e_1_3_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.radcr.2024.01.073"},{"key":"e_1_3_9_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00596334"},{"key":"e_1_3_9_6_2","article-title":"Cerebral infarction pattern in tuberculous meningitis","volume":"6","author":"M-LS Tai","year":"2016","unstructured":"M-LS Tai, , Viswanathan S, , Rahmat K, . Cerebral infarction pattern in tuberculous meningitis. Sci Rep 2016; 6: 38802.","journal-title":"Sci Rep"},{"key":"e_1_3_9_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/17520363.2024.2347194"},{"key":"e_1_3_9_8_2","first-page":"5","article-title":"Central nervous system tuberculosis","author":"Leonard JM.","year":"2017","unstructured":"Leonard JM. Central nervous system tuberculosis. Microbiol Spectr 2017; 5. DOI: 10.1128\/microbiolspec.tnmi7-0044\u20132017","journal-title":"Microbiol Spectr"},{"key":"e_1_3_9_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4471-5226-2_22"},{"key":"e_1_3_9_10_2","unstructured":"Slane VH and Unakal CG. Tuberculous meningitis. In: StatPearls Treasure Island (FL): StatPearls Publishing. http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK541015\/ (2025 accessed 1 February 2025)."},{"key":"e_1_3_9_11_2","first-page":"OD03","article-title":"Immunologic cerebral vasculitis and extrapulmonary tuberculosis: An uncommon association","volume":"9","author":"Wang Y","year":"2015","unstructured":"Wang Y, , Li Q, , Zhen X, . Immunologic cerebral vasculitis and extrapulmonary tuberculosis: An uncommon association. J Clin Diagn Res 2015; 9: OD03\u2013OD05.","journal-title":"J Clin Diagn Res"},{"key":"e_1_3_9_12_2","first-page":"12","article-title":"Acute ischemic stroke in tuberculous meningitis","author":"Y-J Guo","unstructured":"Y-J Guo, , X-L Gan, , R-Y Zhang, . Acute ischemic stroke in tuberculous meningitis. Front Public Health 12. DOI: 10.3389\/fpubh.2024.1362465.","journal-title":"Front Public Health"},{"key":"e_1_3_9_13_2","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S392040"},{"key":"e_1_3_9_14_2","first-page":"32","article-title":"Prognostic identifier of cerebrovascular complications in tuberculous meningitis: Meta-analysis","author":"Tomidy J","unstructured":"Tomidy J, , Satriadinatha GBY, , Liwang FK, . Prognostic identifier of cerebrovascular complications in tuberculous meningitis: Meta-analysis. J Stroke Cerebrovasc Dis 32. DOI: 10.1016\/j.jstrokecerebrovasdis.2023.107371","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"e_1_3_9_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11940-018-0490-9"},{"key":"e_1_3_9_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.MR0318-102R"},{"key":"e_1_3_9_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2021.100819"},{"key":"e_1_3_9_18_2","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1H307"},{"key":"e_1_3_9_19_2","doi-asserted-by":"publisher","DOI":"10.12688\/wellcomeopenres.16474.2"},{"key":"e_1_3_9_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(12)70321-3"},{"key":"e_1_3_9_21_2","article-title":"Corticosteroids for managing tuberculous meningitis","volume":"2016","author":"Prasad K","year":"2016","unstructured":"Prasad K, , Singh MB, and Ryan H. Corticosteroids for managing tuberculous meningitis. Cochrane Database Syst Rev 2016; 2016: CD002244.","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_9_22_2","doi-asserted-by":"publisher","DOI":"10.1179\/000349809X12502035776315"},{"key":"e_1_3_9_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70168-6"},{"key":"e_1_3_9_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(10)70138-9"},{"key":"e_1_3_9_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2023.03.006"},{"key":"e_1_3_9_26_2","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S396022"},{"key":"e_1_3_9_27_2","doi-asserted-by":"publisher","DOI":"10.1177\/1971400919881188"},{"key":"e_1_3_9_28_2","doi-asserted-by":"publisher","DOI":"10.4103\/0028-3886.170086"},{"key":"e_1_3_9_29_2","doi-asserted-by":"publisher","DOI":"10.4103\/ijmr.IJMR_786_17"},{"key":"e_1_3_9_30_2","doi-asserted-by":"publisher","DOI":"10.5588\/ijtld.11.0692"},{"key":"e_1_3_9_31_2","first-page":"2","article-title":"Invasive pressure monitoring saves from tuberculous meningitis with fulminant generalized brain edema","author":"Trendelenburg G","unstructured":"Trendelenburg G, , Jussen D, , Grimmer S, . Invasive pressure monitoring saves from tuberculous meningitis with fulminant generalized brain edema. Front Neurol 2. DOI: 10.3389\/fneur.2011.00069","journal-title":"Front Neurol"}],"container-title":["Annals of Neurosciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09727531251322546","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09727531251322546","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09727531251322546","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:59:43Z","timestamp":1777373983000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09727531251322546"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,18]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1177\/09727531251322546"],"URL":"https:\/\/doi.org\/10.1177\/09727531251322546","relation":{},"ISSN":["0972-7531","0976-3260"],"issn-type":[{"value":"0972-7531","type":"print"},{"value":"0976-3260","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,18]]}}}