{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T22:33:35Z","timestamp":1777415615077,"version":"3.51.4"},"reference-count":38,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurosciences"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Neurocognitive dysfunction is the most common neurological complication seen in homozygous sickle cell disease (SCD) patients, and it appears to be associated with the severity of anaemia, indicating hypoxic brain injury as a causative factor, but the studies are limited to the paediatric population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>We aimed to investigate the neurocognitive profile in adult homozygous SCD patients by subjective (Montreal Cognitive Assessment [MoCA] questionnaire) as well as objective (P300 event-related potentials [ERPs]) cognitive tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Thirty adult homozygous SCD patients and 30 age-matched healthy controls were recruited. The MoCA questionnaire was employed for subjective cognitive status. ERP was recorded by using a modified 3-stimulus auditory oddball paradigm, which contains frequent, rare and novel stimuli. Amplitudes and latencies of corresponding original and difference ERP components were measured and analysed independently. Source analysis was done using sLORETA for P3a and P3b ERP components and compared between healthy controls and SCD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We found a significant reduction in total MoCA scores as well as their domains in SCD patients as compared to controls. For ERP, we found reduced amplitudes and increased latencies of P300 in SCD patients. This phenomenon was further validated in analysis of difference P3 components (P3dT i.e. target minus standard and P3dN i.e. novel minus standard). Additionally, we also found negative correlation between P3a\/P3dN latency and attention domain of MoCA. Further, we found a diminished source activity for P3a and P3b in SCD as compared to control subjects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These results indicate impaired neurocognitive abilities in cognitive domains of adult homozygous SCD patients like attention, executive functions and working memory, and reduced source activities of P300 components which may be due to chronic cerebral hypoxia in these patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09727531251403321","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T05:51:01Z","timestamp":1768888261000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Electrophysiological and Psychological Correlates of Cognition in Adult Homozygous Sickle Cell Disease Patients"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2721-7432","authenticated-orcid":false,"given":"Tarun","family":"Sahu","sequence":"first","affiliation":[{"name":"Electrophysiology Lab, Department of Physiology, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4913-7369","authenticated-orcid":false,"given":"Meenakshi","family":"Sinha","sequence":"additional","affiliation":[{"name":"Electrophysiology Lab, Department of Physiology, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1129-5935","authenticated-orcid":false,"given":"Ramanjan","family":"Sinha","sequence":"additional","affiliation":[{"name":"Electrophysiology Lab, Department of Physiology, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Preetam","family":"Wasnik","sequence":"additional","affiliation":[{"name":"Department of General Medicine, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avinash","family":"Ingle","sequence":"additional","affiliation":[{"name":"Electrophysiology Lab, Department of Physiology, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9032-1227","authenticated-orcid":false,"given":"Sai Krishna","family":"Tikka","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, All India Institute of Medical Sciences, Bibinagar, Telangana, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,1,19]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)07330-3"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30193-9"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1510865"},{"key":"e_1_3_7_5_2","first-page":"1","article-title":"Sickle cell disease","volume":"4","author":"Kato GJ","year":"2018","unstructured":"Kato GJ, , Piel FB, , Reid CD, . Sickle cell disease. Nat Rev Dis Prim 2018; 4: 1\u201322.","journal-title":"Nat Rev Dis Prim"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00871"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/09727531221108871"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-019-0932-0"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.14423\/SMJ.0000000000000511"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.18188"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.4103\/0972-6748.57865"},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004691-199210000-00002"},{"key":"e_1_3_7_13_2","doi-asserted-by":"publisher","DOI":"10.55782\/ane-2012-1880"},{"key":"e_1_3_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2007.04.019"},{"key":"e_1_3_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2007.03.003"},{"key":"e_1_3_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpsycho.2005.12.012"},{"key":"e_1_3_7_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02333854"},{"key":"e_1_3_7_18_2","doi-asserted-by":"publisher","DOI":"10.3109\/14992020903321742"},{"key":"e_1_3_7_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13232"},{"key":"e_1_3_7_20_2","doi-asserted-by":"publisher","DOI":"10.3390\/children10030532"},{"key":"e_1_3_7_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/jsz031"},{"key":"e_1_3_7_22_2","first-page":"91","article-title":"Functional imaging with low-resolution brain electromagnetic tomography (LORETA): A review","volume":"24","author":"Pascual-Marqui RD","year":"2002","unstructured":"Pascual-Marqui RD, , Esslen M, , Kochi K, . Functional imaging with low-resolution brain electromagnetic tomography (LORETA): A review. Methods Find Exp Clin Pharmacol 2002; 24 (Suppl C): 91\u201395.","journal-title":"Methods Find Exp Clin Pharmacol"},{"key":"e_1_3_7_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12687-015-0222-8"},{"key":"e_1_3_7_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.53221.x"},{"key":"e_1_3_7_25_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-019-1305-7"},{"key":"e_1_3_7_26_2","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/879716"},{"key":"e_1_3_7_27_2","doi-asserted-by":"publisher","DOI":"10.1109\/TNSRE.2021.3057384"},{"key":"e_1_3_7_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.01.021"},{"key":"e_1_3_7_29_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2012.00171"},{"key":"e_1_3_7_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/1469-8986.3510023"},{"key":"e_1_3_7_31_2","doi-asserted-by":"publisher","DOI":"10.55782\/ane-2012-1880"},{"key":"e_1_3_7_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.1058"},{"key":"e_1_3_7_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/jsx115"},{"key":"e_1_3_7_34_2","first-page":"1","article-title":"Pattern of auditory and cognitive impairment in children with sickle cell disease: Single center experience","volume":"3","author":"Youssry I","year":"2023","unstructured":"Youssry I, , Shennawy A, , Salam A, . Pattern of auditory and cognitive impairment in children with sickle cell disease: Single center experience. Pediatr Sci J 2023; 3: 1-10.","journal-title":"Pediatr Sci J"},{"key":"e_1_3_7_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhn193"},{"key":"e_1_3_7_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0193(200102)12:2<100::AID-HBM1007>3.0.CO;2-6"},{"key":"e_1_3_7_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-004-0469-2"},{"key":"e_1_3_7_38_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4227-13.2014"},{"key":"e_1_3_7_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12496"}],"container-title":["Annals of Neurosciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09727531251403321","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09727531251403321","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09727531251403321","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:00:17Z","timestamp":1777374017000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09727531251403321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,19]]},"references-count":38,"alternative-id":["10.1177\/09727531251403321"],"URL":"https:\/\/doi.org\/10.1177\/09727531251403321","relation":{},"ISSN":["0972-7531","0976-3260"],"issn-type":[{"value":"0972-7531","type":"print"},{"value":"0976-3260","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,19]]},"article-number":"09727531251403321"}}