{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T13:00:00Z","timestamp":1780750800713,"version":"3.54.1"},"reference-count":84,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T00:00:00Z","timestamp":1780185600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T00:00:00Z","timestamp":1780185600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurosciences"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Alzheimer\u2019s disease (AD) is the leading cause of dementia worldwide, contributing to nearly 60%-70% of dementia cases. Current pharmacological treatments provide limited symptomatic relief and minimal efficacy in altering disease progression, highlighting the need for complementary interventions. Mind-body practices such as yoga and meditation are increasingly explored for preserving cognitive abilities and reducing neurodegenerative risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>This systematic review evaluated randomized controlled trials investigating yoga, meditation, and related mind-body interventions on cognitive and neural health in individuals with normal cognition, mild cognitive impairment, or subjective memory decline. Following PRISMA guidelines, studies published up to March 2025 were reviewed. Findings showed improvements in memory, attention, executive functions, mood, and quality of life. Neurobiological benefits included preservation of hippocampal volume, improved functional connectivity, increased brain-derived neurotrophic factor levels, and reduced neuroinflammation markers. However, methodological limitations such as small sample sizes and short intervention durations were common.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Message<\/jats:title>\n                    <jats:p>Mind-body interventions show promising cognitive and neurobiological benefits in populations at risk of AD. Yoga and meditation may serve as feasible, cost-effective complementary approaches alongside conventional therapy. Larger long-term clinical trials are needed to establish standardized protocols and sustained therapeutic effectiveness.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09727531261441080","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T05:41:35Z","timestamp":1780292495000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Mind\u2013Body Interventions as Modulators of Neural Connectivity and Cognition in Individuals at Risk for Alzheimer\u2019s Disease: A Systematic Review"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0960-2166","authenticated-orcid":false,"given":"Dwivedi","family":"Krishna","sequence":"first","affiliation":[{"name":"Division of Yoga and Life Sciences, Swami Vivekananda Yoga Anusandhana Samasthana (S-VYASA), Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avinash Chandra","family":"Pandey","sequence":"additional","affiliation":[{"name":"Inter-University Centre for Yogic Sciences (IUC-YS), New Delhi, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saurav","family":"Nilesh","sequence":"additional","affiliation":[{"name":"Division of Yoga and Life Sciences, Swami Vivekananda Yoga Anusandhana Samasthana (S-VYASA), Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sridam","family":"Anand","sequence":"additional","affiliation":[{"name":"Sri Guru Ram Rai Institute of Medical Sciences, Dehradun, Uttarakhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2471-8135","authenticated-orcid":false,"given":"Jyoti Amit","family":"Singh","sequence":"additional","affiliation":[{"name":"Division of Yoga and Life Sciences, Swami Vivekananda Yoga Anusandhana Samasthana (S-VYASA), Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Singh","sequence":"additional","affiliation":[{"name":"Division of Yoga and Life Sciences, Swami Vivekananda Yoga Anusandhana Samasthana (S-VYASA), Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,31]]},"reference":[{"key":"e_1_3_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(21)00249-8"},{"key":"e_1_3_8_3_2","first-page":"13","article-title":"The current status, trends, and challenges of Alzheimer\u2019s disease and other dementias in Asia (1990\u20132036)","volume":"2025","author":"He Z","unstructured":"He Z, , Zhang H, , Hu G, . 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